Abstract: A sterilization pouch that includes a perimeter, a first end, a second end, a length extending from the first end to the second end, a first side, a second side, a width extending from the first side to the second side, a first layer, a second layer bonded to the first layer along a portion of the perimeter to define a pouch having an opening and an interior space for receiving an article therein, a first interior sterilization indicator that changes from a first color state to a second color state when exposed to a sterilization condition, the first interior sterilization indicator being disposed between the first layer and the second layer, being disposed along a major portion of the length of the pouch, being disposed along a major portion of the width of the pouch, or being disposed along both a major portion of the length of the pouch and along a major portion of the width of the pouch, the sterilization indicator being visible through the first layer.