Patents by Inventor Deb Chatterjee
Deb Chatterjee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230144683Abstract: A platform and method for determining critical transcription factors for TF-based hiPSC differentiation. The platform including: a transcriptomic dataset database; at least a processor; a memory communicatively connected to the processor, the memory containing instructions configuring the at least a processor to generate gene regulatory networks from transcriptomic datasets; determine a candidate transcription factor; analyze an impact of the candidate transcription factor in germline cell development; and output a set of critical transcription factors.Type: ApplicationFiled: November 7, 2022Publication date: May 11, 2023Applicant: Gameto, IncInventors: Pranam Deb Chatterjee, Christian Kramme
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Patent number: 10577397Abstract: The present invention provides methods and compositions for protein delivery. The invention features virus like particles, methods of making virus like particles and methods of using virus like particles to deliver proteins to a cell, to provide protein therapy and to treat diseases or disorders. The invention also features methods of targeting a protein to a cell, methods of protein therapy and methods of treating diseases or disorders using a TUS protein, a NLS or NES identified from full length TUS.Type: GrantFiled: July 20, 2018Date of Patent: March 3, 2020Assignee: The USA, as represented by the Secretary, Dept. of Health and Human ServicesInventors: Deb Chatterjee, Stanislaw Jan Kaczmarczyk
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Publication number: 20190135869Abstract: The present invention provides methods and compositions for protein delivery. The invention features virus like particles, methods of making virus like particles and methods of using virus like particles to deliver proteins to a cell, to provide protein therapy and to treat diseases or disorders. The invention also features methods of targeting a protein to a cell, methods of protein therapy and methods of treating diseases or disorders using a TUS protein, a NLS or NES identified from full length TUS.Type: ApplicationFiled: July 20, 2018Publication date: May 9, 2019Inventors: Deb Chatterjee, Stanislaw Jan Kaczmarczyk
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Patent number: 10040830Abstract: The present invention provides methods and compositions for protein delivery. The invention features virus like particles, methods of making virus like particles and methods of using virus like particles to deliver proteins to a cell, to provide protein therapy and to treat diseases or disorders. The invention also features methods of targeting a protein to a cell, methods of protein therapy and methods of treating diseases or disorders using a TUS protein, a NLS or NES identified from full length TUS.Type: GrantFiled: March 28, 2016Date of Patent: August 7, 2018Assignee: The United States of America, as represented by the Secretary, Dept. of Health and Human ServicesInventors: Deb Chatterjee, Stanislaw Jan Kaczmarczyk
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Patent number: 9409942Abstract: The current invention provides methods for producing a polypeptide as inclusion bodies in bacterial host cells. The present methods are carried out by forming a gene construct comprising the genetic sequence encoding a polypeptide operatively linked to that of an inclusion partner protein, such that host cells comprising the gene construct produce the polypeptide as intracellular inclusion bodies thereby facilitating rapid isolation and purification of recombinant proteins. The invention further provides methods for producing protein molecular weight ladders for us in protein gel electrophoresis, as well as proteins and protein molecular weight ladders produced by these methods.Type: GrantFiled: July 25, 2013Date of Patent: August 9, 2016Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Deb Chatterjee, Mary Longo, Elizabeth Flynn, Robert Oberfelder
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Publication number: 20160199511Abstract: The present invention provides methods and compositions for protein delivery. The invention features virus like particles, methods of making virus like particles and methods of using virus like particles to deliver proteins to a cell, to provide protein therapy and to treat diseases or disorders. The invention also features methods of targeting a protein to a cell, methods of protein therapy and methods of treating diseases or disorders using a TUS protein, a NLS or NES identified from full length TUS.Type: ApplicationFiled: March 28, 2016Publication date: July 14, 2016Inventors: Deb Chatterjee, Stanislaw Jan Kaczmarczyk
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Patent number: 9296790Abstract: The present invention provides methods and compositions for protein delivery. The invention features virus like particles, methods of making virus like particles and methods of using virus like particles to deliver proteins to a cell, to provide protein therapy and to treat diseases or disorders. The invention also features methods of targeting a protein to a cell, methods of protein therapy and methods of treating diseases or disorders using a TUS protein, a NLS or NES identified from full length TUS.Type: GrantFiled: October 2, 2009Date of Patent: March 29, 2016Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Deb Chatterjee, Stanislaw Jan Kaczmarcyk
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Publication number: 20160024494Abstract: The present invention relates to nucleic acid inhibitors, compositions and method for enhancing synthesis of nucleic acid molecules. In a preferred aspect, the invention relates to inhibition or control of nucleic acid synthesis, sequencing or amplification. Specifically, the present invention discloses nucleic acids having affinity for polypeptides with polymerase activity for use in such synthesis, amplification or sequencing reactions. The nucleic acid inhibitors are capable of inhibiting nonspecific nucleic acid synthesis under certain conditions (e.g., at ambient temperatures). Thus, in a preferred aspect, the invention relates to “hot start” synthesis of nucleic acid molecules. Accordingly, the invention prevents, reduces or substantially reduces nonspecific nucleic acid synthesis. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the nucleic acid inhibitors or compositions of the invention.Type: ApplicationFiled: October 5, 2015Publication date: January 28, 2016Inventors: Mekbib ASTATKE, Deb Chatterjee, Gary Gerard
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Patent number: 8519099Abstract: The current invention provides methods for producing a polypeptide as inclusion bodies in bacterial host cells. The present methods are carried out by forming a gene construct comprising the genetic sequence encoding a polypeptide operatively linked to that of an inclusion partner protein, such as E. coli thioredoxin or a modified E. coli thioredoxin, such that host cells comprising the gene construct produce the polypeptide as intracellular inclusion bodies. The methods of the present invention facilitate the rapid isolation and purification of recombinant proteins. In addition, the present methods may be useful for producing polypeptides or proteins which are small and are typically difficult to express, as well as those proteins that are toxic to host cells such as E. coli. The present invention also provides plasmids, vectors and host cells to be used in the present invention for production of polypeptides, and methods of production of polypeptides using these vectors and host cells.Type: GrantFiled: January 13, 2011Date of Patent: August 27, 2013Assignee: Life Technologies CorporationInventors: Deb Chatterjee, Mary Longo, Elizabeth Flynn, Robert Oberfelder
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Publication number: 20110189159Abstract: The present invention provides methods and compositions for protein delivery. The invention features virus like particles, methods of making virus like particles and methods of using virus like particles to deliver proteins to a cell, to provide protein therapy and to treat diseases or disorders. The invention also features methods of targeting a protein to a cell, methods of protein therapy and methods of treating diseases or disorders using a TUS protein, a NLS or NES identified from full length TUS.Type: ApplicationFiled: October 2, 2009Publication date: August 4, 2011Applicant: The United states of America as presented by the S deparetment of Health and human servicesInventors: Deb Chatterjee, Stanislaw Jan Kaczmarcyk
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Publication number: 20070269878Abstract: The present invention is generally related to compositions and methods for the reverse transcription of nucleic acid molecules, especially messenger RNA molecules. Specifically, the invention relates to compositions comprising mixtures of polypeptides having reverse transcriptase (RT) activity, and to methods of producing, amplifying or sequencing nucleic acid molecules (particularly cDNA molecules) using these compositions or polypeptides, particularly at temperatures above about 55° C. The invention also relates to nucleic acid molecules produced by these methods, to vectors and host cells comprising these nucleic acid molecules, and to the use of such nucleic acid molecules to produce desired polypeptides.Type: ApplicationFiled: March 23, 2007Publication date: November 22, 2007Applicant: INVITROGEN CORPORATIONInventors: Gary Gerard, Michael Smith, Deb Chatterjee
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Publication number: 20070190606Abstract: The current invention provides methods for producing a polypeptide as inclusion bodies in bacterial host cells. The present methods are carried out by forming a gene construct comprising the genetic sequence encoding a polypeptide operatively linked to that of an inclusion partner protein, such as E. coli thioredoxin or a modified E. coli thioredoxin, such that host cells comprising the gene construct produce the polypeptide as intracellular inclusion bodies. The methods of the present invention facilitate the rapid isolation and purification of recombinant proteins. In addition, the present methods may be useful for producing polypeptides or proteins which are small and are typically difficult to express, as well as those proteins that are toxic to host cells such as E. coli. The present invention also provides plasmids, vectors and host cells to be used in the present invention for production of polypeptides, and methods of production of polypeptides using these vectors and host cells.Type: ApplicationFiled: December 29, 2006Publication date: August 16, 2007Applicant: INVITROGEN CORPORATIONInventors: Deb Chatterjee, Mary Longo, Elizabeth Flynn, Robert Oberfelder
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Publication number: 20070184527Abstract: The current invention provides methods for producing a polypeptide as inclusion bodies in bacterial host cells. The present methods are carried out by forming a gene construct comprising the genetic sequence encoding a polypeptide operatively linked to that of an inclusion partner protein, such as E. coli thioredoxin or a modified E. coli thioredoxin, such that host cells comprising the gene construct produce the polypeptide as intracellular inclusion bodies. The methods of the present invention facilitate the rapid isolation and purification of recombinant proteins. In addition, the present methods may be useful for producing polypeptides or proteins which are small and are typically difficult to express, as well as those proteins that are toxic to host cells such as E. coli. The present invention also provides plasmids, vectors and host cells to be used in the present invention for production of polypeptides, and methods of production of polypeptides using these vectors and host cells.Type: ApplicationFiled: December 29, 2006Publication date: August 9, 2007Applicant: INVITROGEN CORPORATIONInventors: Deb CHATTERJEE, Mary LONGO, Elizabeth FLYNN, Robert OBERFELDER
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Publication number: 20070178489Abstract: The present invention relates to polypeptides, compositions and methods for enhancing synthesis of nucleic acid molecules. In a preferred aspect, the invention relates to inhibition or control of nucleic acid synthesis, sequencing or amplification. Specifically, the present invention discloses polypeptides having affinity for double-stranded and/or single-stranded nucleic acid molecules and/or single-stranded/double-stranded nucleic acid complexes (e.g., primer/template complexes, double-stranded templates, single-stranded templates or single-stranded primers) for use in such enhanced synthesis and more particularly to polymerases having reduced polymerase and optionally reduced exonuclease activities (3? to 5? and/or 5? to 3? exonuclease activity), and to nucleases having reduced nuclease activity. The polypeptides of the invention are capable of inhibiting nonspecific nucleic acid synthesis at ambient temperature.Type: ApplicationFiled: October 6, 2006Publication date: August 2, 2007Applicant: Invitrogen CorporationInventors: Mekbib Astatke, Deb Chatterjee, Harini Shadilya
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Publication number: 20070087356Abstract: The invention provides a microarray and methods for producing a protein microarray. The array comprises multiple nucleic acid molecules immobilized on a substrate, each comprising (i) a protein-binding domain and (ii) a nucleic acid sequence encoding a fusion protein comprising a polypeptide of interest and a DNA-binding protein that binds the protein-binding domain, and one or more fusion proteins produced from the multiple nucleic acid molecules. Each fusion protein is immobilized on the substrate via binding to a nucleic acid sequence comprising the protein-binding domain present on the nucleic acid molecule from which the fusion protein is produced or on the substrate. The invention also provides a method of analyzing protein interactions with, for example, other proteins, lipids and drugs.Type: ApplicationFiled: October 19, 2005Publication date: April 19, 2007Applicant: Government of the USA, represented by the Secretary, Department of Health & Human ServicesInventors: Deb Chatterjee, Kalavathy Sitaraman, James Hartley, Cassio Baptista, David Munroe
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Publication number: 20060286633Abstract: The current invention provides methods for producing a polypeptide as inclusion bodies in bacterial host cells. The present methods are carried out by forming a gene construct comprising the genetic sequence encoding a polypeptide operatively linked to that of an inclusion partner protein, such as E. coli thioredoxin or a modified E. coli thioredoxin, such that host cells comprising the gene construct produce the polypeptide as intracellular inclusion bodies. The methods of the present invention facilitate the rapid isolation and purification of recombinant proteins. In addition, the present methods may be useful for producing polypeptides or proteins which are small and are typically difficult to express, as well as those proteins that are toxic to host cells such as E. coli. The present invention also provides plasmids, vectors and host cells to be used in the present invention for production of polypeptides, and methods of production of polypeptides using these vectors and host cells.Type: ApplicationFiled: January 11, 2006Publication date: December 21, 2006Applicant: Invitrogen CorporationInventors: Deb Chatterjee, Mary Longo, Elizabeth Flynn, Robert Oberfelder
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Publication number: 20060269992Abstract: The current invention provides methods for producing a polypeptide as inclusion bodies in bacterial host cells. The present methods are carried out by forming a gene construct comprising the genetic sequence encoding a polypeptide operatively linked to that of an inclusion partner protein, such as E. coli thioredoxin or a modified E. coli thioredoxin, such that host cells comprising the gene construct produce the polypeptide as intracellular inclusion bodies. The methods of the present invention facilitate the rapid isolation and purification of recombinant proteins. In addition, the present methods may be useful for producing polypeptides or proteins which are small and are typically difficult to express, as well as those proteins that are toxic to host cells such as E. coli. The present invention also provides plasmids, vectors and host cells to be used in the present invention for production of polypeptides, and methods of production of polypeptides using these vectors and host cells.Type: ApplicationFiled: January 11, 2006Publication date: November 30, 2006Applicant: Invitrogen CorporationInventors: Deb Chatterjee, Mary Longo, Elizabeth Flynn, Robert Oberfelder
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Publication number: 20060134739Abstract: In Vitro peptide/protein or biological macromolecule synthesis systems, and methods and kits thereof improve efficiency of in vitro protein or biological macromolecule synthesis and related compositions.Type: ApplicationFiled: March 10, 2004Publication date: June 22, 2006Inventor: Deb Chatterjee
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Publication number: 20050123905Abstract: The present invention is directed generally to methods facilitating the cloning of nucleic acid molecules. In particular, the invention relates to the use of polymerase inhibitors, including but not limited to anti-polymerase antibodies (such as anti-Taq antibodies) and fragments thereof, to inactivate residual polymerase activity remaining after the amplification (particularly via PCR) of a target nucleic acid molecule. The invention further provides compositions, particularly storage-stable compositions, comprising one or more components, such as one or more restriction endonucleases and one or more polymerase inhibitors, that are useful in cloning amplified or synthesized nucleic acid molecules by the above-described methods. The invention also relates to nucleic acid molecules produced by these methods, and to genetic constructs (such as vectors) and host cells comprising these nucleic acid molecules.Type: ApplicationFiled: October 8, 2004Publication date: June 9, 2005Applicant: Invitrogen CorporationInventors: Donna Fox, Deb Chatterjee
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Publication number: 20050112637Abstract: The present invention relates to mutant DNA polymerases which incorporate dideoxynucleotides with about the same efficiency as deoxynucleotides. The present invention also related to mutant DNA polymerases which also have substantially reduced 5?-to-3? exonuclease activity or 3?-to-5? exonuclease activity. The invention also relates to DNA molecules coding for the mutant DNA polymerases, and hosts containing the DNA molecules.Type: ApplicationFiled: September 23, 2004Publication date: May 26, 2005Inventor: Deb Chatterjee