Patents by Inventor Debabrata Saha

Debabrata Saha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10953209
    Abstract: Tumor-Treating Fields elicit a conditional vulnerability to PARP inhibitors (e.g., Olaparib) in certain cancer cells such as non-small cell lung cancer (NSCLC) cell lines. This conditional vulnerability is exploited in a method of killing cancer cells that comprises delivering a PARP inhibitor to the cancer cells and applying an alternating 80-300 kHz electric field to the cancer cells. At least a portion of the applying step is performed simultaneously with at least a portion of the delivering step. In some embodiments, an additional step of treating the cancer cells with a radiation therapy is added to the method. In some embodiments, the frequency of the alternating electric field is between 100 and 200 kHz.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: March 23, 2021
    Assignee: Board of Regents of the University of Texas System
    Inventors: Michael Story, Debabrata Saha, Narasimha Kumar Karanam
  • Patent number: 10765745
    Abstract: In one aspect, compositions comprising a population of core-shell nanoparticles are described herein. In some cases, the population of core-shell nanoparticles comprises a core component and a shell component encapsulating or surrounding the core component. Additionally, one or more radiosensitizers are disposed in or dispersed throughout the core component, or an interior region of the core component. Similarly, one or more chemotherapeutic agents are disposed in or dispersed throughout the shell component, or an interior region of the shell component. Moreover, in some cases, the core component is formed from one or more biodegradable polymers. Further, in some instances, the shell component is formed from one or more stimuli responsive polymers, such as a temperature-responsive polymer and/or pH-responsive polymer.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: September 8, 2020
    Assignee: Board of Regents, the University of Texas System
    Inventors: Kytai Nguyen, Jyothi Menon, Debabrata Saha
  • Publication number: 20190298982
    Abstract: Tumor-Treating Fields elicit a conditional vulnerability to PARP inhibitors (e.g., Olaparib) in certain cancer cells such as non-small cell lung cancer (NSCLC) cell lines. This conditional vulnerability is exploited in a method of killing cancer cells that comprises delivering a PARP inhibitor to the cancer cells and applying an alternating 80-300 kHz electric field to the cancer cells. At least a portion of the applying step is performed simultaneously with at least a portion of the delivering step. In some embodiments, an additional step of treating the cancer cells with a radiation therapy is added to the method. In some embodiments, the frequency of the alternating electric field is between 100 and 200 kHz.
    Type: Application
    Filed: March 28, 2018
    Publication date: October 3, 2019
    Inventors: Michael Story, Debabrata Saha, Narasimha Kumar Karanam
  • Publication number: 20170065523
    Abstract: In one aspect, compositions comprising a population of core-shell nanoparticles are described herein. In some cases, the population of core-shell nanoparticles comprises a core component and a shell component encapsulating or surrounding the core component. Additionally, one or more radiosensitizers are disposed in or dispersed throughout the core component, or an interior region of the core component. Similarly, one or more chemotherapeutic agents are disposed in or dispersed throughout the shell component, or an interior region of the shell component. Moreover, in some cases, the core component is formed from one or more biodegradable polymers. Further, in some instances, the shell component is formed from one or more stimuli responsive polymers, such as a temperature-responsive polymer and/or pH-responsive polymer.
    Type: Application
    Filed: September 9, 2016
    Publication date: March 9, 2017
    Inventors: Kytai NGUYEN, Jyothi Menon, Debabrata Saha
  • Patent number: 4730344
    Abstract: Methods for modulating and demodulating digital data streams utilize a quadrature-quadrature phase shift keying data transmission arrangement to acheive a 100% increase in the bandwidth efficiency over known systems, such as minimum shift keying. Known arrangements utilize two dimensional data transmission. However, Q.sup.2 PSK, in accordance with the invention, provides four dimensional transmission which doubles the rate of data transmission for a given bandwidth, at the expense of approximately 45% increase in the average energy per bit. The input data stream is demultiplexed to form four demultiplexed data streams which are formed of demultiplexed data bits, each such stream being coded to form a stream of data words formed of a predetermined number of data pulses and a parity check bit. Each such data stream is combined with a signal having carrier and data pulse-shaping components.
    Type: Grant
    Filed: March 19, 1987
    Date of Patent: March 8, 1988
    Assignee: The University of Michigan
    Inventor: Debabrata Saha
  • Patent number: 4680777
    Abstract: Methods for modulating and demodulating digital data streams utilize a quadrature-quadrature phase shift keying data transmission arrangement to achieve a 100% increase in the bandwidth efficiency over known systems, such as minimum shift keying. Known arrangements utilize two dimensional data transmission. However, Q.sup.2 PSK, in accordance with the invention, provides four dimensional transmission which doubles the rate of data transmission for a given bandwidth, at the expense of approximately 45% increase in the average energy per bit. The input data stream is demultiplexed to form four demultiplexed data streams which are formed of demultiplexed data bits. Each such data stream is combined with a signal having carrier and data pulse-shaping components. Additionally, the data pulse-shaping components have a quadrature phase relationship with each other, thereby adding the additional two dimensions of data transmission capacity.
    Type: Grant
    Filed: August 13, 1984
    Date of Patent: July 14, 1987
    Assignee: The University of Michigan
    Inventor: Debabrata Saha