Patents by Inventor Debashis MANDAL

Debashis MANDAL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DESACETOXYTUBULYSIN H AND ANALOGS THEREOF
    Publication number: 20180127463
    Abstract: In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein R1, R2, R3, R4, X1, X2, X3, and A1 are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein.
    Type: Application
    Filed: February 25, 2016
    Publication date: May 10, 2018
    Applicant: William Marsh Rice University
    Inventors: Kyriacos C. NICOLAOU, Dionisios VOURLOUMIS, Jun YIN, Rohan ERANDE, Debashis MANDAL, Phillipp KLAHN
  • DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS
    Publication number: 20180065976
    Abstract: In one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.
    Type: Application
    Filed: August 15, 2017
    Publication date: March 8, 2018
    Applicants: WILLIAM MARSH RICE UNIVERSITY, BRISTOL-MYERS SQUIBB COMPANY, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Kyriacos C. NICOLAOU, Min LU, Debashis MANDAL, Sanjeev GANGWAR, Naidu S. CHOWDARI, Yam B. POUDEL
  • Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents
    Patent number: 9777013
    Abstract: In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (II).
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: October 3, 2017
    Assignees: WILLIAM MARSH RICE UNIVERSITY, THE SCRIPPS RESEARCH INSTITUTE, BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Kyriacos C. Nicolaou, Min Lu, Debashis Mandal, Sanjeev Gangwar, Naidu S. Chowdari, Yam B. Poudel
  • DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS
    Publication number: 20160185791
    Abstract: In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (II).
    Type: Application
    Filed: August 14, 2014
    Publication date: June 30, 2016
    Applicants: WILLIAM MARSH RICE UNIVERSITY, BRISTOL-MYERS SQUIBB COMPANY, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Kyriacos C. NICOLAOU, Min LU, Debashis MANDAL, Sanjeev GANGWAR, Naidu S. CHOWDARI, Yam B. POUDEL