Abstract: This invention deals with a novel straight chain compound, namely, 1,6-diamino alkanoic acid having a straight chain of six carbon atoms with two terminal amino groups and accompanying —COOH group, which is capable of effecting controlled formation of new blood vessels in ischaemic tissues, and their pharmaceutically acceptable salts and/or derivatives thereof. The compounds may be in laevo, dextro, activated laevo, activated dextro or oligomeric form. The invention also pertains to a process for preparing the aforesaid novel compound, which is illustrated by the accompanying drawing.

Abstract: Present invention provides a method for treating cancer which comprises co-administration of an angiogenic agent to enhance the vascular supply within tumors, particularly tumors capable of maintaining their viability under hypoxic conditions, and a anticancer therapy (e.g. chemotherapy and radiation therapy) to which the cancer is susceptible. Induction of angiogenesis increases the delivery of anticancer agents to the hypoxic tumor cells within the tumors, and as a result, improves the effectiveness of the anticancer therapy in eliminating or reducing cancers. The present invention also includes formulations comprising of lysine(L- and/or D-isomers as well as, or, their “activated” version either in isolation or in various combinations, as described, along with additive(s) and one or more chemotherapeutic agent(s) and/or radio-sensitizing agent(s).

Abstract: A method of stimulating angiogenesis in a mammal suffering from heart or cerebral or neural disease, comprising administering to said mammal a therapeutic composition comprising free cationic amino acid lysine or free salt thereof, in an amount that induces cardiac or cerebral or neural reperfusion in the mammal.

Abstract: A method for treating intrauterine growth retardation in an animal, such as a human being, is disclosed comprising administration of a lysine composition.

Abstract: Present invention features methods for induction of angiogenesis by administration of lysine (l-&d-) or lysine oligomers (molecular weight approx between 500 and 2500), both homo and hetero-oligomers, consisting of either l-or d- or both enantiomers.