Patents by Inventor Debbiao Zhao

Debbiao Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Telomerizing nuclear donor cells and improving the efficiency on nuclear transfer
    Patent number: 7265262
    Abstract: This disclosure provides a system for creating cloned cells and embryos that are genetically modified. Cells are treated to increase expression of telomerase and potentially extend replicative capacity. One or more genetic modifications is made to inactivate a gene or confer desirable features, growing and selecting the cells as needed. The modified nucleus can then be transferred to a suitable recipient cell, which can then be used to grow an embryo with the conferred attributes. This technology makes it possible to create embryos, animals and embryonic cell lines with multiple genetic modifications, including homozygously inactivated genes and gene substitutions.
    Type: Grant
    Filed: March 21, 2002
    Date of Patent: September 4, 2007
    Assignee: Roslin Institute (Edinburgh)
    Inventors: A. John Clark, Wei Cui, Chris Denning, Debbiao Zhao
  • Vectors for telomerizing nuclear donor cells and improving the efficiency of nuclear transfer
    Publication number: 20030175967
    Abstract: This disclosure provides a system for creating cloned cells and embryos that are genetically modified. Cells are treated to increase expression of telomerase and potentially extend replicative capacity. One or more genetic modifications is made to inactivate a gene or confer desirable features, growing and selecting the cells as needed. The modified nucleus can then be transferred to a suitable recipient cell, which can then be used to grow an embryo with the conferred attributes. This technology makes it possible to create embryos, animals and embryonic cell lines with multiple genetic modifications, including homozygously inactivated genes and gene substitutions.
    Type: Application
    Filed: March 21, 2002
    Publication date: September 18, 2003
    Inventors: A. John Clark, Wei Cui, Chris Denning, Debbiao Zhao