Patents by Inventor Debbie C. Crans

Debbie C. Crans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240124501
    Abstract: Disclosed are vanadium (V) compounds and pharmaceutical compositions comprising these vanadium compounds. Also disclosed are methods of making and using these vanadium compounds, for example, to treat cancer (e.g., including brain cancer).
    Type: Application
    Filed: August 21, 2023
    Publication date: April 18, 2024
    Inventors: Debbie C. CRANS, Peter A. LAY, Heide MURAKAMI, Aviva LEVINA, Kateryna KOSTENKOVA, Andrew BATES, John MANGANARO, Josef GRUNDY, Skyler MARKHAM, Kameron KLUGH
  • Publication number: 20220396593
    Abstract: The present application relates to preparation methods and uses of vanadium complexes providing a consistent and stable preparation. More specifically, the present application relates to preparation of vanadium citrate salts, phosphate salts, or combinations thereof, characterization of the properties of such salts, and methods using the same.
    Type: Application
    Filed: June 1, 2022
    Publication date: December 15, 2022
    Inventors: Debbie C. Crans, Heide Murakami, Kateryna Kostenkova
  • Patent number: 4701285
    Abstract: This invention consists of the production of a salt of acyl phosphate in an aqueous solution by a process which involves (1) acylation of phosphoric acid (H.sub.3 PO.sub.4) with an acid anhydride of the general formula RCOX, where R can be hydrogen or a lower alkyl or aryl group having from 1 to 10 carbon atoms, and X can be a leaving group of the general formula OR, OCOR, X or NR.sub.2, followed by (2a) extraction of acyl phosphate to water by treatment of the reaction mixture with an aqueous bicarbonate or hydroxide solution or other basic aqueous solution, if the reaction is carried out in non-aqueous solvent or (2b) in the case where water has been used as reaction solvent acidification with acid or acid form of a carbon exchange resin.
    Type: Grant
    Filed: October 31, 1985
    Date of Patent: October 20, 1987
    Assignee: Massachusetts Institute of Technology
    Inventors: George M. Whitesides, Debbie C. Crans, Romas J. Kazlaukas