Patents by Inventor Debbie Mitra

Debbie Mitra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic Supernatant from Cell-Seeded Substrates and Related Methods
    Publication number: 20240049701
    Abstract: Disclosed herein are methods and compositions for the identification of viability enhancing cell features and substrate features as they relate to post-cryopreservation survival of substrate seeded cells. Embodiments of the present invention further involve identification of cell features to manufacture a supernatant that is useful for cell culturing and treatment of various diseases.
    Type: Application
    Filed: October 10, 2023
    Publication date: February 15, 2024
    Applicants: University of Southern California, The Regents of the University of California
    Inventors: Britney O. Pennington, Jeffrey K. Bailey, Mohamed A. Faynus, Cassidy Arnold, Lincoln V. Johnson, Dennis O. Clegg, Mark S. Humayun, David R. Hinton, Danhong Zhu, Debbie Mitra
  • Cryopreservation of cell-seeded substrates and related methods
    Patent number: 11825839
    Abstract: Disclosed herein are methods and compositions for the identification of viability enhancing cell features and substrate features as they relate to post-cryopreservation survival of substrate seeded cells. Embodiments of the present invention further involve identification of cell features to manufacture a supernatant that is useful for cell culturing and treatment of various diseases.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: November 28, 2023
    Assignees: University of Southern California, The Regents of the University of California
    Inventors: Britney O. Pennington, Jeffrey K. Bailey, Mohamed A. Faynus, Cassidy Arnold, Lincoln V. Johnson, Dennis O. Clegg, Mark S. Humayun, David R. Hinton, Danhong Zhu, Debbie Mitra
  • CRYOPRESERVATION OF CELL-SEEDED SUBSTRATES AND RELATED METHODS
    Publication number: 20200077641
    Abstract: Disclosed herein are methods and compositions for the identification of viability enhancing cell features and substrate features as they relate to post-cryopreservation survival of substrate seeded cells. Embodiments of the present invention further involve identification of cell features to manufacture a supernatant that is useful for cell culturing and treatment of various diseases.
    Type: Application
    Filed: August 30, 2019
    Publication date: March 12, 2020
    Applicants: University of Southern California, The Regents of the University of California
    Inventors: Britney O. Pennington, Jeffrey K. Bailey, Mohamed A. Faynus, Cassidy Arnold, Lincoln V. Johnson, Dennis O. Clegg, Mark S. Humayun, David R. Hinton, Danhong Zhu, Debbie Mitra
  • RNA monomers containing 0-acetal levulinyl ester groups and their use in RNA microarrays
    Patent number: 10287313
    Abstract: The present invention is directed to RNA monomers comprising O-acetal levulinyl protecting groups at the 2? and/or the 5?-hydroxy functionalities of the ribose moiety. Said monomers may be incorporated into oligoribonucleotides or RNA polynucleotides. Furthermore, the invention is directed to methods for the synthesis of said RNA monomers, oligoribonucleotides and RNA polynucleotides, as well as methods for their deprotection and methods for the use of said compounds and compositions comprising said compounds. In particular, such compounds and compositions comprising them are used in methods for light-directed synthesis of RNA microarrays.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: May 14, 2019
    Assignees: The Royal Institution for the Advancement of Learning/McGill University, Wisconsin Alumni Research Foundation
    Inventors: Masad Damha, Jeremy Lackey, Debbie Mitra, Marvin Wickens, Franco Cerrina, Mark Somoza
  • RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS
    Publication number: 20160340382
    Abstract: The present invention is directed to RNA monomers comprising O-acetal levulinyl protecting groups at the 2? and/or the 5?-hydroxy functionalities of the ribose moiety. Said monomers may be incorporated into oligoribonucleotides or RNA polynucleotides. Furthermore, the invention is directed to methods for the synthesis of said RNA monomers, oligoribonucleotides and RNA polynucleotides, as well as methods for their deprotection and methods for the use of said compounds and compositions comprising said compounds. In particular, such compounds and compositions comprising them are used in methods for light-directed synthesis of RNA microarrays.
    Type: Application
    Filed: December 29, 2015
    Publication date: November 24, 2016
    Applicants: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Masad Damha, Jeremy Lackey, Debbie Mitra, Marvin Wickens, Franco Cerrina, Mark Somoza
  • RNA monomers containing O-acetal levulinyl ester groups and their use in RNA microarrays
    Patent number: 9249175
    Abstract: The present invention is directed to RNA monomers comprising O-acetal levulinyl protecting groups at the 2? and/or the 5?-hydroxy functionalities of the ribose moiety. Said monomers may be incorporated into oligoribonucleotides or RNA polynucleotides. Furthermore, the invention is directed to methods for the synthesis of said RNA monomers, oligoribonucleotides and RNA polynucleotides, as well as methods for their deprotection and methods for the use of said compounds and compositions comprising said compounds. In particular, such compounds and compositions comprising them are used in methods for light-directed synthesis of RNA microarrays.
    Type: Grant
    Filed: September 4, 2009
    Date of Patent: February 2, 2016
    Assignees: The Royal Institute for the Advancement of Learning/McGill University, Wisconsin Alumni Research Foundation
    Inventors: Masad Damha, Jeremy Lackey, Debbie Mitra, Marvin Wickens, Franco Cerrina, Saima A. Akhtar, Mark Somoza
  • RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS
    Publication number: 20120178638
    Abstract: The present invention is directed to RNA monomers comprising O-acetal levulinyl protecting groups at the 2? and/or the 5?-hydroxy functionalities of the ribose moiety. Said monomers may be incorporated into oligoribonucleotides or RNA polynucleotides. Furthermore, the invention is directed to methods for the synthesis of said RNA monomers, oligoribonucleotides and RNA polynucleotides, as well as methods for their deprotection and methods for the use of said compounds and compositions comprising said compounds. In particular, such compounds and compositions comprising them are used in methods for light-directed synthesis of RNA microarrays.
    Type: Application
    Filed: September 4, 2009
    Publication date: July 12, 2012
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Masad Damha, Jeremy Lackey, Debbie Mitra, Marvin Wickens, Franco Cerrina, Saima A. Akhtar, Mark Somoza