Patents by Inventor Debbie R. Moorad

Debbie R. Moorad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Buforin I as a specific inhibitor and therapeutic agent for botulinum toxin B and tetanus neurotoxins
    Patent number: 6713444
    Abstract: The compounds of the invention are generally described by the formula: X1X2B3X4B5X*6X7X8 B9X10B11X12B13X14 B15X16B17X*18X*19B20 X21X22X23Q24F25Z*26X27 X28B29X30B31B32X33X34 B35B36X37Z38Z39  (1) and the salts, esters, amides, and acyl forms thereof. Up to 15 amino acids may be truncated from the N-terminus and up to 6 amino acids may be truncated from the C-terminus. Each position represented by a letter indicates a single amino acid residue wherein B is a basic or polar/large amino acid or a modified form thereof; X is a small or hydrophobic amino acid or a modified form thereof; X* is a small or polar/large amino acid or a modified form thereof; Z is a polar/large or hydrophobic amino acid or a modified form thereof; Z* is Proline or a polar/large or hydrophobic amino acid or a modified form thereof. These compounds may be used to inhibit the protease activity of Botulinum B and tetanus toxins.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: March 30, 2004
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Gregory E. Garcia, Richard K. Gordon, Debbie R. Moorad, Bhupendra P. Doctor
  • Previns as specific inhibitors and therapeutic agents for Botulinum toxin B and Tetanus neurotoxins
    Patent number: 6573244
    Abstract: The compounds of the invention are generally described by the formula: B1Z*2B3Z*4X*5Q6F7X8X9X10X11  (1), B1X2X3X4X5Q6F7X8X9X10X11  (2), or B1X2B3X4Z5Q6F7Z*8X9X10X11  (3) and the salts, esters, amides, and acyl forms thereof. Each position represented by a letter indicates a single amino acid residue: B is a basic or polar/large amino acid or a modified form thereof; X is a small or hydrophobic amino acid or a modified form thereof; X* is a small or polar/large amino acid or a modified form thereof; Z is a polar/large or hydrophobic amino acid or a modified form thereof; Z* is Proline or a polar/large or hydrophobic amino acid or a modified form thereof. As described below, one or more of the peptide linkages between the amino acid residues may be replaced by a peptide linkage mimic. These compounds may be used as molecular building blocks to create compounds that are optimized for inhibiting the protease activity of Botulinum B and tetanus toxins.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: June 3, 2003
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Richard K. Gordon, Debbie R. Moorad, Bhupendra P. Doctor, Gregory E. Garcia