Abstract: An emergency response system including a smoke detector and an evacuation guide. The emergency response system and evacuation guide are separate components removably attached to each other, and each has a shape that includes a long, narrow neck and a curved handle, which permits both the smoke detector and evacuation guide to be installed by hanging each from a door knob. The smoke detector includes, in addition to means for sensing smoke and means for emitting an alarm, a radio transmitter that generates and transmits an activation signal in the form of radio waves. The radio waves are detected by a radio receiver in the evacuation guide. Upon receipt of the activation signal, a digital recording and playback device delivers a message to occupants of the home or building. A flashlight contained within the evacuation guide also is illuminated.