Abstract: A collagen-coated tissue based membrane that is smooth on both sides so as to inhibit cell and tissue adhesion. Also disclosed are methods for making a collagen-coated tissue-based membrane.

Abstract: A method for preparing carbonate apatite from natural bones. The method includes obtaining cancellous bone particles; treating the bone particles with hot water and an organic solvent; repeating the treating step at least once; drying the bone particles; and heating the bone particles at 500° C. to 620° C. for 10 to 50 hours.

Abstract: A flat self-curling permeable sheet membrane containing a matrix formed of crosslinked biopolymeric fibers. The matrix self-curls into a predetermined shape upon absorption of an aqueous fluid and is permeable to molecules having molecular weights not greater than 1×106 daltons. Also disclosed is a method of preparing such a flat self-curling permeable membrane.

Abstract: The present invention relates to a conformable and semi-permeable biopolymeric membrane suitable for tissue repair and protection. This membrane contains a first layer made from randomly oriented, reconstituted biopolymer fibers and, on top of the first layer, a coating layer made from biopolymer fibers.

Abstract: A compressed implant composite for repairing mineralized tissue. The compressed implant composite includes a matrix formed of biopolymeric fibers and a plurality of calcium- and/or silicate-based mineral particles dispersed in the matrix. The matrix constitutes 4 to 80% by weight and the mineral particles constitute 20 to 96% by weight of the composite. The composite is free of soluble collagen and is expandable to a volume 2 to 100 times of its compressed volume (e.g., upon absorption of water). Also disclosed are methods of preparing the above-described composite.

Abstract: This invention relates to a method for preparing a porous bone implant containing a calcium-based mineral. The method includes immersing a porous matrix in an acidic solution containing a calcium-based mineral; removing the matrix from the solution; and exposing the matrix to an alkali to neutralize the acidic solution, thereby causing precipitation of the calcium-based mineral to obtain a porous bone implant containing a calcium-based mineral.

Abstract: This invention relates to a sheet membrane for repairing a damaged tissue. The membrane includes an isotropic layer of cross-linked biopolymeric fibers in which the fibers are 10 to 1,000 cm in length. This invention also relates to a method of making an isotropic layer of cross-linked biopolymeric fibers. The method includes: (1) coacervating biopolymeric fibers (e.g., collagen-based fibers) having lengths of less than 1 cm dispersed in an aqueous solution to obtain coacervated biopolymeric fibers having lengths of 10 to 1,000 cm; (2) flattening the coacervated biopolymeric fibers into a layer; (3) drying the layer; and (4) cross-linking the biopolymeric.

Abstract: This invention relates to a sheet membrane for repairing a damaged tissue. The membrane includes an isotropic layer of cross-linked biopolymeric fibers in which the fibers are 10 to 1,000 cm in length. This invention also relates to a method of making an isotropic layer of cross-linked biopolymeric fibers. The method includes: (1) coacervating biopolymeric fibers (e.g., collagen-based fibers) having lengths of less than 1 cm dispersed in an aqueous solution to obtain coacervated biopolymeric fibers having lengths of 10 to 1,000 cm; (2) flattening the coacervated biopolymeric fibers into a layer; (3) drying the layer; and (4) cross-linking the biopolymeric.

Abstract: The present invention relates to a conformable and semi-permeable biopolymeric membrane suitable for tissue repair and protection. This membrane contains a first layer made from randomly oriented, reconstituted biopolymer fibers and, on top of the first layer, a coating layer made from biopolymer fibers.

Abstract: A re-rollable membrane for wrapping around and protecting a cylindrical tissue having an injury site. The membrane includes a sheet of a porous matrix formed of cross-linked biopolymeric fibers. In one implementation, the sheet can be spirally rolled so that at least one portion overlaps another portion of the sheet and, upon absorption of a fluid, the overlapping portions adhere to each other closely so as to exclude penetration of cells. In another implementation, the sheet can be helically rolled to form a helix having a pitch of 2 mm to 40 mm and an inner diameter of 1 mm to 50 mm. Also disclosed are methods for making and using such re-rollable membranes.

Abstract: A bone implant composite comprising a collagen matrix and a calcium-based mineral, the calcium-based mineral having a particle size of 25-2000 ?m and being interspersed in the collagen matrix; wherein the bone implant composite contains 3-60% by weight the collagen matrix and 40-97% by weight the calcium-based mineral, and has a pore size of 50-500 ?m, a density range of 0.02-0.8 g/cm3, a tensile strength range of 0.4-100 kg/cm2, and a compression modulus range of 0.2-10 kg/cm2. Also disclosed are methods of preparing the above-described composite.

Abstract: This invention relates to a method for preparing a porous bone implant containing a calcium-based mineral. The method includes immersing a porous matrix in an acidic solution containing a calcium-based mineral; removing the matrix from the solution; and exposing the matrix to an alkali to neutralize the acidic solution, thereby causing precipitation of the calcium-based mineral to obtain a porous bone implant containing a calcium-based mineral.

Abstract: A bone implant composite comprising a collagen matrix and a calcium-based mineral, the calcium-based mineral having a particle size of 25-2000 ?m and being interspersed in the collagen matrix; wherein the bone implant composite contains 3-60% by weight the collagen matrix and 40-97% by weight the calcium-based mineral, and has a pore size of 50-500 ?m, a density range of 0.02-0.8 g/cm3, and a tensile strength range of 0.4-100 kg/cm2. Also disclosed are methods of preparing the above-described composite.

Abstract: A bone implant composite comprising a collagen matrix and a calcium-based mineral, the calcium-based mineral having a particle size of 25-2000 ?m and being interspersed in the collagen matrix; wherein the bone implant composite contains 3-60% by weight the collagen matrix and 40-97% by weight the calcium-based mineral, and has a pore size of 50-500 ?m, a density range of 0.02-0.8 g/cm3, a tensile strength range of 0.4-100 kg/cm2, and a compression modulus range of 0.2-10 kg/cm2. Also disclosed are methods of preparing the above-described composite.

Abstract: A bone implant composite comprising a collagen matrix and a calcium-based mineral, the calcium-based mineral having a particle size of 25-2000 ?m and being interspersed in the collagen matrix; wherein the bone implant composite contains 3-60% by weight the collagen matrix and 40-97% by weight the calcium-based mineral, and has a pore size of 50-500 ?m, a density range of 0.02-0.8 g/cm3, and a tensile strength range of 0.4-100 kg/cm2. Also disclosed are methods of preparing the above-described composite.

Abstract: A cell occlusion sheet membrane adapted for repairing a damaged meningeal tissue. The sheet membrane contains a layer of cross-linked, oriented biopolymeric fibers that has a thickness of 0.1 mm to 3.0 mm, a density of 0.1 g/cm3 to 1.2 g/cm3, a hydrothermal shrinkage temperature of 45° C. to 80° C., a suture pullout strength of 0.1 kg to 5 kg, a tensile strength of 10 kg/cm2 to 150 kg/cm2, and permeability to molecules having molecular weights of 200 to 300,000 daltons. Also disclosed is a method for making the membrane.

Abstract: This invention relates to a sheet membrane for repairing a damaged tissue. The membrane includes an isotropic layer of cross-linked biopolymeric fibers in which the fibers are 10 to 1,000 cm in length. This invention also relates to a method of making an isotropic layer of cross-linked biopolymeric fibers. The method includes: (1) coacervating biopolymeric fibers (e.g., collagen-based fibers) having lengths of less than 1 cm dispersed in an aqueous solution to obtain coacervated biopolymeric fibers having lengths of 10 to 1,000 cm; (2) flattening the coacervated biopolymeric fibers into a layer; (3) drying the layer; and (4) cross-linking the biopolymeric.

Abstract: An implant containing a support member and a biopolymer-based material formed integrally on a surface of the support member. The support member is dimensionally manipulatable, and the integrity of the biopolymer-based material is independent of dimensional changes in the support member. Also disclosed is a method of preparing such an implant.

Abstract: An implant device including a tubular matrix made of a biocompatible and bioresorbable biopolymeric material. The matrix has a first end and a second end, a wall of a homogeneous thickness; a plurality of ridges on the wall; and a channel which is defined by the wall and extends from the first end to the second end of the tubular matrix.

Abstract: A cell occlusion sheet membrane adapted for repairing a damaged meningeal tissue. The sheet membrane contains a layer of cross-linked, oriented biopolymeric fibers that has a thickness of 0.1 mm to 3.0 mm, a density of 0.1 g/cm3 to 1.2 g/cm3, a hydrothermal shrinkage temperature of 45° C. to 80° C., a suture pullout strength of 0.1 kg to 5 kg, a tensile strength of 10 kg/cm2 to 150 kg/cm2 , and permeability to molecules having molecular weights of 200 to 300,000 daltons. Also disclosed is a method for making the membrane.