Patents by Inventor Debiao Li
Debiao Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11935158Abstract: A method for performing real-time magnetic resonance (MR) imaging on a subject is disclosed. A prep pulse sequence is applied to the subject to obtain a high-quality special subspace, and a direct linear mapping from k-space training data to subspace coordinates. A live pulse sequence is then applied to the subject. During the live pulse sequence, real-time images are constructed using a fast matrix multiplication procedure on a single instance of the k-space training readout (e.g., a single k-space line or trajectory), which can be acquired at a high temporal rate.Type: GrantFiled: May 4, 2021Date of Patent: March 19, 2024Assignee: Cedars-Sinai Medical CenterInventors: Anthony Christodoulou, Zhaoyang Fan, Debiao Li, Pei Han
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Patent number: 11796616Abstract: A method of performing multidimensional magnetic resonance imaging on a subject comprises collecting imaging data for a region of interest of the subject, the imaging data related to one or more spatially-varying parameters of the subject within the region of interest; collecting auxiliary data for the region of interest in the subject, the auxiliary data related to one or more time-varying parameters of the subject within the region of interest; linking the imaging data and the auxiliary data; and constructing an image tensor with one or more temporal dimensions based on at least a portion of the linked imaging data and at least a portion of the linked auxiliary data.Type: GrantFiled: May 28, 2021Date of Patent: October 24, 2023Assignee: CEDARS-SINAI MEDICAL CENTERInventors: Debiao Li, Anthony Christodoulou, Zhaoyang Fan, Zixin Deng, Nan Wang, Zhengwei Zhou, Sen Ma, Christopher Nguyen, Yibin Xie, Jaime Shaw
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Publication number: 20230225628Abstract: A method for performing magnetic resonance imaging on a subject comprises: injecting a contrast agent into a region of interest of the subject; applying a pulse sequence to the region of interest; collecting auxiliary data for the region of interest, the auxiliary data being related to one or more time-varying parameters of the subject within the region of interest; determining a temporal factor ? from the auxiliary data; collecting imaging data for the region of interest, the imaging data being related to one or more spatially-varying parameters of the subject within the region of interest; determining a spatial factor Ur from the imaging data; modeling a multi-dimensional image sequence as I=Ur?; and deriving at least a first metric and a second metric from the multi-dimensional image sequence I, the first metric and the second metric being associated with distinct perfusion-based imaging techniques.Type: ApplicationFiled: June 16, 2021Publication date: July 20, 2023Applicant: CEDARS-SINAI MEDICAL CENTERInventors: Zhaoyang Fan, Anthony Christodoulou, Debiao Li, Zhehao Hu
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Publication number: 20230222708Abstract: A method for performing real-time magnetic resonance (MR) imaging on a subject is disclosed. A prep pulse sequence is applied to the subject to obtain a high-quality special subspace, and a direct linear mapping from k-space training data to subspace coordinates. A live pulse sequence is then applied to the subject. During the live pulse sequence, real-time images are constructed using a fast matrix multiplication procedure on a single instance of the k-space training readout (e.g., a single k-space line or trajectory), which can be acquired at a high temporal rate.Type: ApplicationFiled: May 4, 2021Publication date: July 13, 2023Inventors: Anthony Christodoulou, Zhaoyang Fan, Debiao Li, Pei Han
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SYSTEMS AND METHODS OF DEEP LEARNING FOR LARGE-SCALE DYNAMIC MAGNETIC RESONANCE IMAGE RECONSTRUCTION
Publication number: 20230194640Abstract: A method for performing magnetic resonance imaging on a subject comprises obtaining undersampled imaging data, extracting one or more temporal basis functions from the imaging data, extracting one or more preliminary spatial weighting functions from the imaging data, inputting the one or more preliminary spatial weighting functions into a neural network to produce one or more final spatial weighting functions, and multiplying the one or more final spatial weighting functions by the one or more temporal basis functions to generate an image sequence. Each of the temporal basis functions corresponds to at least one time-varying dimension of the subject. Each of the preliminary spatial weighting functions corresponds to a spatially-varying dimension of the subject. Each of the final spatial weighting functions is an artifact-free estimation of the one of the one or more preliminary spatial weighting functions.Type: ApplicationFiled: September 10, 2020Publication date: June 22, 2023Inventors: Anthony CHRISTODOULOU, Debiao LI, Yuhua CHEN -
Publication number: 20230079832Abstract: In various embodiments, the invention teaches systems and methods for magnetic resonance imaging. In some embodiments, the invention teaches systems and methods for determining the source of pain in intervertebral discs by measuring one or more physiological biomarkers associated with disc pain and/or disc degeneration.Type: ApplicationFiled: November 14, 2022Publication date: March 16, 2023Applicant: CEDARS-SINAI MEDICAL CENTERInventors: Dan Gazit, Debiao Li, Gadi Pelled, Zulma Gazit, Zhengwei Zhou
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Publication number: 20230071885Abstract: According to some implementations of the present disclosure, a system for identifying individuals at risk for PDAC includes a CT scanner, a memory, and a control system. The CT scanner is configured to generate CT image data associated with a pancreas of a patient. The memory stores machine-readable instructions. The control system includes one or more processors configured to execute the machine-readable instructions. The CT image data associated with the pancreas of the patient is received. The received CT image data is processed to output a set of CT image features. The set of CT image features is received as an input to a machine learning PDAC prediction algorithm. An indication of whether the patient is at high risk for PDAC is determined as an output of the machine learning PDAC prediction algorithm.Type: ApplicationFiled: January 12, 2021Publication date: March 9, 2023Applicants: CEDARS-SINAI MEDICAL CENTER, SOUTHERN CALIFORNIA PERMANENTE MEDICAL GROUPInventors: Bechien Wu, Srinivas Gaddam, Debiao Li, Stephen Jacob Pandol, Touseef Ahmad Qureshi
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Patent number: 11547348Abstract: In various embodiments, the invention teaches systems and methods for magnetic resonance imaging. In some embodiments, the invention teaches systems and methods for determining the source of pain in intervertebral discs by measuring one or more physiological biomarkers associated with disc pain and/or disc degeneration.Type: GrantFiled: June 8, 2017Date of Patent: January 10, 2023Assignee: Cedars-Sinai Medical CenterInventors: Dan Gazit, Debiao Li, Gadi Pelled, Zulma Gazit, Zhengwei Zhou
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Patent number: 11439309Abstract: The invention provides methods for diagnosing coronary heart disease in a subject in need thereof comprising administering an admixture comprising CO2 to a subject to reach a predetermined PaCO2 in the subject to induce hyperemia, monitoring vascular reactivity in the subject and diagnosing the presence or absence of coronary heart disease in the subject, wherein decreased vascular reactivity in the subject compared to a control subject is indicative of coronary heart disease. The invention also provides methods for increasing sensitivity and specificity of BOLD MRI.Type: GrantFiled: May 7, 2012Date of Patent: September 13, 2022Assignee: Cedars-Sinai Medical CenterInventors: Rohan Dharmakumar, Debiao Li, Sotirios A. Tsaftaris
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Patent number: 11415649Abstract: A coil assembly for MR imaging includes an RF coil element and a shim coil array with a shim coil element. The shim coil element is physically separated from the RF coil element. The shim coil element includes a DC current loop having a DC power supply connection to allow DC current to generate a local B0 magnetic field. The coil assembly simultaneously provides an RF mode for at least one of transmit or receive and a direct current mode to generate a local B0 magnetic field for at least one of B0 shimming an imaging space, MRI spatial encoding of tissue spins, or MRI temporal encoding of tissue spins. The mutual inductance between the shim coil element and the RF coil element is minimized by configuration of blocking elements in the shim coil in order to minimize the RF interaction there between.Type: GrantFiled: September 28, 2018Date of Patent: August 16, 2022Inventors: Hui Han, Debiao Li
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Publication number: 20220206094Abstract: A unified coil assembly for magnetic resonance imaging is disclosed. The coil assembly includes an RF coil element and a shim coil array with a shim coil element. The shim coil element is physically separated or partially separated from the RF coil element. The shim coil element includes a DC current loop having a DC power supply connection to allow DC current to generate a local BO magnetic field. The unified coil array assembly is configured to simultaneously provide an RF mode for at least one of transmit or receive and a direct current mode to generate a local BO magnetic field for BO shimming. Larger number of shim coils relative to the RF coil element provides superior shimming performance. The mutual inductance between the shim coil element and the RF coil element is minimized by proposed geometrical decoupling methods in order to minimize the RF interaction between the two.Type: ApplicationFiled: December 8, 2021Publication date: June 30, 2022Applicant: Cedars-Sinai Medical CenterInventors: Hui Han, Debiao Li
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Publication number: 20220138936Abstract: A method of analyzing computed tomography (CT) images comprises receiving an initial CT image of an object, identifying calcium-free regions and a calcified region in the initial CT image of the object, generating a calcium-free image patch, and applying the calcium-free image patch to the initial CT image patch to produce a final CT image. The initial CT image shows a calcium deposit and a target structure in the object. The calcified region in the initial CT image shows the calcium deposit in the object obscuring a portion of the target structure. The calcium-free regions show the remaining portions of the target structure. The calcium-free image patch corresponds to the calcified region in the initial CT image. The final CT image shows the calcium-free image patch and the calcium-free region from the initial CT image. The calcium-free image patch is generated and applied using a convolutional neural network.Type: ApplicationFiled: February 18, 2020Publication date: May 5, 2022Applicant: CEDARS-SINAI MEDICAL CENTERInventors: Yibin Xie, Debiao Li, Damini Dey, Yuhua Chen
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Publication number: 20220099775Abstract: A method of analyzing a multidimensional image tensor containing a plurality of images comprises: performing imaging scans of a subject imaging data; generating the multidimensional image tensor from the imaging data; determining a spatial basis tensor containing basis images based on the multidimensional image tensor; determining a temporal basis tensor containing basis functions for a temporal dimension based on the multidimensional image tensor; determining a core tensor that relates the spatial basis tensor to the temporal basis tensor; pre-multiplying the core tensor and the temporal basis tensor to produce a modified temporal basis tensor; storing the spatial basis tensor and the modified temporal basis tensor; and generating an image by multiplying at least (i) at least a portion of the spatial basis tensor and (ii) at least a portion of the modified temporal basis tensor.Type: ApplicationFiled: September 18, 2019Publication date: March 31, 2022Inventors: Debiao LI, Anthony CHRISTODOULOU, Yibin XIE
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Publication number: 20220054661Abstract: There are provided methods for diagnosing coronary heart disease in a subject in need thereof comprising administering an admixture comprising CO2 to a subject to reach a predetermined PaCO2 in the subject to induce hyperemia, monitoring vascular reactivity in the subject and diagnosing the presence or absence of coronary heart disease in the subject, wherein decreased vascular reactivity in the subject compared to a control subject is indicative of coronary heart disease. There are also provided methods for increasing sensitivity and specificity of BOLD MRI.Type: ApplicationFiled: August 31, 2021Publication date: February 24, 2022Applicant: Cedars-Sinai Medical CenterInventors: Rohan DHARMAKUMAR, Debiao LI, Sotirios A. TSAFTARIS
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Patent number: 11209510Abstract: A unified coil assembly for magnetic resonance imaging is disclosed. The coil assembly includes an RF coil element and a shim coil array with a shim coil element. The shim coil element is physically separated or partially separated from the RF coil element. The shim coil element includes a DC current loop having a DC power supply connection to allow DC current to generate a local BO magnetic field. The unified coil array assembly is configured to simultaneously provide an RF mode for at least one of transmit or receive and a direct current mode to generate a local B0 magnetic field for B0 shimming Larger number of shim coils relative to the RF coil element provides superior shimming performance. The mutual inductance between the shim coil element and the RF coil element is minimized by proposed geometrical decoupling methods in order to minimize the RF interaction between the two.Type: GrantFiled: November 3, 2016Date of Patent: December 28, 2021Assignee: Cedars-Sinai Medical CenterInventors: Hui Han, Debiao Li
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Publication number: 20210356544Abstract: A method of performing multidimensional magnetic resonance imaging on a subject comprises collecting imaging data for a region of interest of the subject, the imaging data related to one or more spatially-varying parameters of the subject within the region of interest; collecting auxiliary data for the region of interest in the subject, the auxiliary data related to one or more time-varying parameters of the subject within the region of interest; linking the imaging data and the auxiliary data; and constructing an image tensor with one or more temporal dimensions based on at least a portion of the linked imaging data and at least a portion of the linked auxiliary data.Type: ApplicationFiled: May 28, 2021Publication date: November 18, 2021Inventors: Debiao Li, Anthony Christodoulou, Zhaoyang Fan, Zixin Deng, Nan Wang, Zhengwei Zhou, Sen Ma, Christopher Nguyen, Yibin Xie, Jaime Shaw
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Patent number: 11129911Abstract: There are provided methods for diagnosing coronary heart disease in a subject in need thereof comprising administering an admixture comprising CO2 to a subject to reach a predetermined PaCO2 in the subject to induce hyperemia, monitoring vascular reactivity in the subject and diagnosing the presence or absence of coronary heart disease in the subject, wherein decreased vascular reactivity in the subject compared to a control subject is indicative of coronary heart disease. There are also provided methods for increasing sensitivity and specificity of BOLD MRI.Type: GrantFiled: March 2, 2018Date of Patent: September 28, 2021Assignee: CEDARS-SINAI MEDICAL CENTERInventors: Rohan Dharmakumar, Debiao Li, Sotirios A. Tsaftaris
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Patent number: 11039757Abstract: In various embodiments, the present invention teaches methods and related systems for imaging the coronary arteries in high spatiotemporal resolution for the assessment of coronary stenosis. In some embodiments, the method teaches the use of a 3D radial k-space trajectory, continuous acquisition, retrospective cardiac and respiratory self-gating, and non-rigid cardiac and respiratory motion correction to reconstruct any arbitrary cardiac phase with minimal motion artifacts and high image quality.Type: GrantFiled: November 22, 2016Date of Patent: June 22, 2021Assignee: Cedars-Sinai Medical CenterInventors: Debiao Li, Jianing Pang
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Patent number: 11022666Abstract: A method of performing multidimensional magnetic resonance imaging on a subject comprises collecting imaging data for a region of interest of the subject, the imaging data related to one or more spatially-varying parameters of the subject within the region of interest; collecting auxiliary data for the region of interest in the subject, the auxiliary data related to one or more time-varying parameters of the subject within the region of interest; linking the imaging data and the auxiliary data; and constructing an image tensor with one or more temporal dimensions based on at least a portion of the linked imaging data and at least a portion of the linked auxiliary data.Type: GrantFiled: May 8, 2019Date of Patent: June 1, 2021Assignee: Cedars-Sinai Medical CenterInventors: Debiao Li, Anthony Christodoulou, Zhaoyang Fan, Zixin Deng, Nan Wang, Zhengwei Zhou, Sen Ma, Christopher Nguyen, Yibin Xie, Jaime Shaw
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Patent number: 10925510Abstract: Magnetic resonance imaging utilizing a continuous spoiled gradient echo sequence with 3D radial trajectory and 1D self-gating for respiratory motion detection can be used to characterize respirator motion in the abdomen. The resulting image data is acquired and is retrospectively sorted into different respiratory phases based on their temporal locations within a respiratory cycle, and each phase is reconstructed via a self-calibrating conjugate gradient sensitivity encoding (CG-SENSE) program.Type: GrantFiled: May 8, 2015Date of Patent: February 23, 2021Assignee: Cedars-Sinai Medical CenterInventors: Zhaoyang Fan, Jianing Pang, Zixin Deng, Debiao Li