Patents by Inventor Debora Foguel

Debora Foguel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of hydrostatic pressure to inhibit and reverse protein aggregation and facilitate protein refolding
    Patent number: 7615617
    Abstract: A novel approach is described for reversing aggregation and increasing refolding by application of hydrostatic pressure. A protein of interest in an aggregated, or inclusion body, or other non-native or inactive state is subjected to high hydrostatic pressure. This treatment denatures the protein to states (or conformations) competant for refolding and results in increased formation of native protein once pressure is released. The technique can facilitate conversion non-native proteins, including inclusion bodies and aggregates to native proteins without addition of chaotropic agents, changes in buffer, or large-scale dilution of reagents required for traditional refolding methods.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: November 10, 2009
    Assignee: University of Delaware
    Inventors: Anne Skaja Robinson, Clifford R. Robinson, Debora Foguel, Jerson Lima Silva
  • Use of hydrostatic pressure to inhibit and reverse protein aggregation and facilitate protein refolding
    Publication number: 20050020818
    Abstract: A novel approach is described for reversing aggregation and increasing refolding by application of hydrostatic pressure. A protein of interest in an aggregated, or inclusion body, or other non-native or inactive state is subjected to high hydrostatic pressure. This treatment denatures the protein to states (or conformations) competant for refolding and results in increased formation of native protein once pressure is released. The technique can facilitate conversion non-native proteins, including inclusion bodies and aggregates to native proteins without addition of chaotropic agents, changes in buffer, or large-scale dilution of reagents required for traditional refolding methods.
    Type: Application
    Filed: September 26, 2003
    Publication date: January 27, 2005
    Inventors: Anne Robinson, Clifford Robinson, Debora Foguel, Jerson Silva