Patents by Inventor Debora Kramer

Debora Kramer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polyamine analog-activated SSAT gene therapy
    Patent number: 6413775
    Abstract: The present invention provides a novel method to increase both the antitumor potency and the selectivity of DENSPM, a polyamine analog. The method comprises the steps increasing the amount of SSAT mRNA, and delivering a therapeutically sufficient dose of DENSPM which allows conversion of SSAT mRNA to enzyme activity, polyamine pool depletion and growth inhibition. The SSAT mRNA may be increased by conditionally induced overexpression of SSAT, or by modulating the transcriptional regulation of the endogenous SSAT gene.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: July 2, 2002
    Assignee: Health Research, Inc.
    Inventors: Carl W. Porter, Slavoljub Vujcic, Debora Kramer, Kristen Kee