Abstract: A hypodermic needle-cap handling device (10) includes a thin rigid plate (12) having an open ended slot (24) therein and a cap holder (16) mounted on one side of plate adjacent the slot for holding a needle cap (36) that has been removed from a hypodermic needle (58) with the aid of handling device. A syringe (54) can be manipulated to move a nose 60 thereof into the slot and when the syringe is thereafter moved laterally away from the plate the needle cap, which cannot pass through the slot, is left on the cap holder. The cap can be reapplied to the needle by reversing this action. The cap holder includes an end abutment (30) against which the cap can be urged when the cap is reapplied and spring clips 38 for positively holding a cap on the cap holder. Guide members (14a and b) guide the nose of the hypodermic syringe into the slot and a clamp 20 clamps the hypodermic needle-cap handling device to a table.