Abstract: In a wearable device and methods of monitoring changes in the volume and properties of human interstitial fluid associated with both normal and disease conditions using limb circumference and acceleration, raw data is transmitted from the wearable device to external devices for storage and evaluation. The data is compared and contrasted with reference information derived for the individual as well as a larger population of individuals and evaluated for wellness and clinical implications. Related messages regarding the state of the individual may be transmitted to concerned parties such as patients, caregivers and medical professionals.

Abstract: The present invention provides devices, systems and methods for RNA isolation from biological samples containing white blood cells, such as whole blood. The devices have a device body that includes a first chamber having a first membrane that selectively binds white blood cells, a second chamber having a second membrane that reversibly binds RNA and a plurality of ports that are removably attached to a reagent pack and waste receptacle via a valving system controlled by a control unit.

Abstract: The present invention provides devices, systems and methods for RNA isolation from biological samples containing white blood cells, such as whole blood. The devices have a device body that includes a first chamber having a first membrane that selectively binds white blood cells, a second chamber having a second membrane that reversibly binds RNA and a plurality of ports that are removably attached to a reagent pack and waste receptacle via a valving system controlled by a control unit.