Abstract: This invention relates to the use of a bisbiguanide compound of the formula:R.sup.1 R.sup.2 N.C(:NH)N:C(NH.sub.2)N--A--N.C(NH.sub.2):N.C(:NH)NR.sup.3 R.sup.4 Iwherein either:(i) R.sup.1 and R.sup.3, which may be the same or different, are each a phenyl radical which is substituted by alkyl, alkoxy, nitro or halogen, R.sup.2 and R.sup.4 are both hydrogen, and A is a 3-9C polymethylene diradical, wherein the polymethylene chain may be interrupted by oxygen atoms and/or by aromatic nuclei; or(ii) the bivalent bridge A is:(a) alkylene of from 2 to 12 carbon atoms having the valence bonds attached to different carbon atoms,(b) --(CH.sub.2).sub.m --X--(CH.sub.2).sub.n -- wherein m an n each represent an integer from 2 to 6 and X is O or S,(c) ##STR1## (d) ##STR2## wherein Z and Z.sup.1 are each alkylene of from 1 to 3 carbon atoms, (e) ##STR3## wherein Q is --O--, --S--, --SO-- or --SO.sub.2 --, (f) ##STR4## R.sup.1 and R.sup.

Abstract: This invention relates to the use of polymeric biguanides as topical contraceptive agents, which operate both by rendering vaginal mucus impenetrable to sperm, or by a direct spermicidal action.