Patents by Inventor Deborah D Jaworski

Deborah D Jaworski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Histidine kinase
    Patent number: 6548281
    Abstract: The invention provides Histidine Kinase polypeptides and polynucleotides encoding Histidine Kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine Kinase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 18, 2000
    Date of Patent: April 15, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Karen M O'Dwyer, Deborah D Jaworski, Jeffrey L Mooney, Lisa K Shilling, John Peter Throup, Nicola Gail Wallis, Yi Yi Zhong, Min Wang
  • Methods of screening for antimicrobial compounds
    Publication number: 20030040032
    Abstract: A method and assay for screening for antimicrobial compound comprises contacting bacteria having a detectable concentration with a target compound and determining the effect of the target compound on the concentration of the bacteria. The effect of the compound is determined by measuring the concentration of the bacteria at a plurality of times after the bacteria is contacted with the candidate compound. The method incorporates an assay, such as an optical density assay, luciferase-based assay, or kinetic assay.
    Type: Application
    Filed: August 23, 2002
    Publication date: February 27, 2003
    Inventors: Peter L. DeMarsh, Robert C. Gagnon, Robert P. Hertzberg, Deborah D. Jaworski
  • GidA1
    Publication number: 20020128437
    Abstract: The invention provides gidA1 polypeptides and polynucleotides encoding gidA1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gidA1 polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: May 21, 2001
    Publication date: September 12, 2002
    Inventors: Jason Craig Fedon, Deborah D. Jaworski, Howard Kallender, Anna Lisa Lenox, Leslie Marie Palmer, Min Wang
  • defl
    Publication number: 20020058796
    Abstract: The invention provides def1 polypeptides and polynucleotides encoding def1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing def1 polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: May 21, 2001
    Publication date: May 16, 2002
    Inventors: Michael A. Lonetto, David J. Holmes, Deborah D. Jaworski, Richard O. Nicholas, Min Wang, Robert K. Stodola, Anna L. Kosmatka, Richard L. Warren, David J.C. Knowles, Christopher M. Traini, John E. Hodgson
  • High throughput assay
    Publication number: 20020025514
    Abstract: A high-throughput live whole cell assay method involves measuring the effect of one or more test compounds on a characteristic, e.g., growth, of a cell culture in a multi-well vessel at one or more timepoints during the growth of these cells in culture, after the cells are contacted with the compound. This assay format permits the identification of test compounds that have an inhibitory or stimulatory effect, among others, on cell growth at different times during the growth phase of the cells. It has the advantages of using small volumes which make the assay suitable for automation and enables detection of test compounds with the desired effect that are often missed by conventional assays which assess test compound activity at a single timepoint.
    Type: Application
    Filed: June 29, 2001
    Publication date: February 28, 2002
    Inventors: Deborah D. Jaworski, Monique F. Murray
  • Streptococcus pneumoniae isoleucyl tRNA synthetase
    Patent number: 6329168
    Abstract: The invention provides ileS polypeptides and DNA (RNA) encoding ileS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ileS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 17, 1997
    Date of Patent: December 11, 2001
    Assignee: SmithKline Beecham Corp.
    Inventors: James R. Brown, Deborah D. Jaworski, Elizabeth J. Lawlor, Min Wang
  • Stretococcal ERS
    Patent number: 6300119
    Abstract: The invention provides gluS polypeptides and DNA (RNA) encoding gluS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gluS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: October 9, 2001
    Inventors: Deborah D. Jaworski, Elizabeth J. Lawlor, Min Wang
  • GidA1
    Patent number: 6238882
    Abstract: The invention provides gidA1 polypeptides and polynucleotides encoding gidA1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gidA1 polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: June 24, 1998
    Date of Patent: May 29, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Jason Craig Fedon, Deborah D Jaworski, Howard Kallender, Anna Lisa Lenox, Leslie Marie Palmer, Min Wang
  • MurB
    Patent number: 6218528
    Abstract: The invention provides MurB polypeptides and polynucleotides encoding MurB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 14, 1998
    Date of Patent: April 17, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Nicola G Wallis, Min Wang, Magdalena Zalacain, Sanjoy Biswas, James Raymond Brown, Alison Frances Chalker, David John Holmes, Karen A Ingraham, Deborah D Jaworski, Jennifer Ray, Lisa K Shilling
  • DnaB
    Patent number: 6204014
    Abstract: The invention provides DnaB polypeptides and polynucleotides encoding DnaB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing DnaB polypeptides to screen for anibacterial compounds.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: March 20, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Alison F Chalker, David J Holmes, Karen A Ingraham, Deborah D Jaworski, Anna L Lenox, Earl W May, Marie J Mazzulla, Jennifer Ray, Min Wang, Richard L Warren, Jr.
  • Streptococcal ERS
    Patent number: 6165760
    Abstract: The invention provides gluS polypeptides and DNA (RNA) encoding gluS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gluS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 31, 1999
    Date of Patent: December 26, 2000
    Assignee: SmithKline Beecham Corporation.
    Inventors: Deborah D. Jaworski, Elizabeth J. Lawlor, Min Wang
  • Valyl tRNA synthetase from Streptococcus pneumoniae
    Patent number: 6051413
    Abstract: The invention provides valS polypeptides and DNA (RNA) encoding valS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing valS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: September 24, 1998
    Date of Patent: April 18, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: James R. Brown, Deborah D. Jaworski, Elizabeth J. Lawlor, Min Wang
  • Polynucleotides encoding gluS polypeptides of streptococcal pneumoniae
    Patent number: 5976840
    Abstract: The invention provides gluS polypeptides and DNA (RNA) encoding gluS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gluS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 31, 1997
    Date of Patent: November 2, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Deborah D. Jaworski, Elizabeth J. Lawlor, Min Wang
  • Valyl trna polynucleotides from Streptococcus pneumoniae
    Patent number: 5849555
    Abstract: The invention provides valS polypeptides and DNA (RNA) encoding valS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing valS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 17, 1997
    Date of Patent: December 15, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: James R. Brown, Deborah D. Jaworski, Elizabeth J. Lawlor, Min Wang