Patents by Inventor Deborah Downs

Deborah Downs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of memapsin 1 cleavage in the treatment of diabetes
    Patent number: 9096541
    Abstract: Proteases such as memapsin-1 are import enzymes, playing roles in a variety of diseases including diabetes. The inventors have developed inhibitors of memapsin 1 and methods of use therefore in the treatment of disease.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: August 4, 2015
    Assignees: Oklahoma Medical Research Foundation, Purdue Research Foundation
    Inventors: Jordan Tang, Xiangping Huang, Deborah Downs, Arun K. Ghosh
  • INHIBITION OF MEMAPSIN 1 CLEAVAGE IN THE TREATMENT OF DIABETES
    Publication number: 20130261052
    Abstract: Proteases such as memapsin-1 are import enzymes, playing roles in a variety of diseases including diabetes. The inventors have developed inhibitors of memapsin 1 and methods of use therefore in the treatment of disease.
    Type: Application
    Filed: March 11, 2013
    Publication date: October 3, 2013
    Applicant: Oklahoma Medical Research Foundation
    Inventors: Jordan Tang, Xiangping Huang, Deborah Downs
  • TRUNCATED MEMAPSIN 2 COMPOSITIONS AND TREATMENTS
    Publication number: 20090214554
    Abstract: The present invention provides novel methods of reducing memapsin 2 ?-secretase activity in a subject, decreasing levels of ?-amyloid peptide in the brain of a subject, treating Alzheimer's disease and/or reducing the size and/or number of ?-amyloid plaques in the brain of a subject. The methods may include the step of administering an effective amount of truncated memapsin 2 protein, anti-truncated memapsin 2 antibody, and/or nucleic acid encoding a truncated memapsin 2 protein or anti-truncated memapsin 2 antibody. The present invention also provides related pharmaceutical compositions and uses thereof.
    Type: Application
    Filed: September 17, 2008
    Publication date: August 27, 2009
    Applicant: Oklahoma Medical Research Foundation
    Inventors: Wan Pin CHANG, Deborah Downs, Jordan J.N. Tang
  • TRUNCATED MEMAPSIN 2 COMPOSITIONS AND TREATMENTS
    Publication number: 20070092517
    Abstract: The present invention provides novel methods of reducing memapsin 2 ?-secretase activity in a subject, decreasing levels of ?-amyloid peptide in the brain of a subject, treating Alzheimer's disease and/or reducing the size and/or number of ?-amyloid plaques in the brain of a subject. The methods may include the step of administering an effective amount of truncated memapsin 2 protein, anti-truncated memapsin 2 antibody, and/or nucleic acid encoding a truncated memapsin 2 protein or anti-truncated memapsin 2 antibody. The present invention also provides related pharmaceutical compositions and uses thereof.
    Type: Application
    Filed: August 9, 2006
    Publication date: April 26, 2007
    Applicant: Oklahoma Medical Research Foundation
    Inventors: Wan Chang, Deborah Downs, Jordan Tang