Abstract: A promoter for high level and sustained expression is provided which can be used for gene expression of chosen sequences in general. In particular, a nucleic acid construct comprising a hCEF1 promoter operably linked to a sequence for expression is provided, where the hCEF1 promoter comprises: (i) a human CMV enhancer operably linked to a human EFI a promoter; (ii) a functional fragment of (i); or (ii) a functional variant of (i) or (ii).

Abstract: A system and methods for maintaining situation awareness about an event are disclosed. The methods includes displaying said the location of the event on a digital reference map that is representative of a geographic area. As amplifying information pertaining to the event is received, the information is displayed at the same pixel location of the digital reference map as the event location to fuse geo-visualization and situation awareness of an event at the same display. Amplifying information can include remote updates from emergency personnel responding to said. A plurality of digital reference maps, corresponding to geographic areas for respective users, can be networked. The result is a network wherein a plurality of corresponding user have real-time situational awareness of critical events within the aggregate geographical area represented by the digital reference maps.

Abstract: A promoter for high level and sustained expression is provided which can be used for gene expression of chosen sequences in general. In particular, a nucleic acid construct comprising a hCEF1 promoter operably linked to a sequence for expression is provided, where the hCEF1 promoter comprises: (i) a human CMV enhancer operably linked to a human EFI a promoter; (ii) a functional fragment of (i); or (ii) a functional variant of (i) or (ii).

Abstract: A promoter for high level and sustained expression is provided which can be used for gene expression of chosen sequences in general. In particular, a nucleic acid construct comprising a hCEF1 promoter operably linked to a sequence for expression is provided, where the hCEF1 promoter comprises: (i) a human CMV enhancer operably linked to a human EF1 a promoter; (ii) a functional fragment of (i); or (ii) a functional variant of (i) or (ii).

Abstract: The present invention relates to medicaments for the treatment of cystic fibrosis. Also provided are methods of preparing such medicaments so that they can be used in a treatment regime for cystic fibrosis. The present invention also provides a kit of parts including the medicament of the invention, as well as treatment regimes for cystic fibrosis.

Abstract: A system and methods for maintaining situation awareness about an event are disclosed. The methods includes displaying said the location of the event on a digital reference map that is representative of a geographic area. As amplifying information pertaining to the event is received, the information is displayed at the same pixel location of the digital reference map as the event location to fuse geo-visualization and situation awareness of an event at the same display. Amplifying information can include remote updates from emergency personnel responding to said. A plurality of digital reference maps, corresponding to geographic areas for respective users, can be networked. The result is a network wherein a plurality of corresponding user have real-time situational awareness of critical events within the aggregate geographical area represented by the digital reference maps.