Patents by Inventor Deborah H. Charych

Deborah H. Charych has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION-BASED TREATMENT METHOD
    Publication number: 20160339013
    Abstract: The invention relates to (among other things) a method comprising the steps of (a) administering to a patient a PARP-inhibiting amount of a PARP inhibitor; and (b) administering to the patient a topoisomerase I-inhibiting amount of a long-acting topoisomerase I inhibitor.
    Type: Application
    Filed: January 13, 2015
    Publication date: November 24, 2016
    Inventors: Ute Hoch, Nancy Marie Burns, Deborah H. Charych
  • FGFR extracellular domain acidic region muteins
    Patent number: 9175065
    Abstract: Fibroblast growth factor receptor (FGFR) extracellular domain (ECD) acidic region muteins that have been engineered to exhibit decreased tissue binding by increasing the number of acidic amino acid residues within the D1-D2 linker region are provided. Polynucleotides encoding FGFR ECD acidic region muteins are also provided. Methods of making FGFR ECD acidic region muteins, and methods of using such molecules to treat proliferative disorders, including cancers, disorders of angiogenesis, and macular degeneration, are also provided.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: November 3, 2015
    Assignee: Five Prime Therapeutics, Inc.
    Inventors: Shannon Marshall, Deborah H. Charych, Ali Sadra
  • Conjugates of an IL-2 Moiety and a Polymer
    Publication number: 20140328791
    Abstract: Conjugates of an IL-2 moiety and one or more nonpeptidic, water-soluble polymers are provided. Typically, the nonpeptidic, water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, methods of administering compositions to an individual, nucleic acid sequences, expression systems, host cells, and methods for preparing IL-moieties.
    Type: Application
    Filed: November 11, 2011
    Publication date: November 6, 2014
    Inventors: Mary J. Bossard, Cherie F. Ali, Xiaofeng Liu, Deborah H. Charych, Harold Zappe, Yujun Wang, Jicai Huang
  • Water-Soluble Polymer-Linked Binding Moiety and Drug Compounds
    Publication number: 20140088021
    Abstract: Compounds comprising a binding moiety, water-soluble, non-peptidic polymer, and drug are provided. Also provided are methods preparing such compounds, compositions comprising such compounds and methods for administering and using such compounds and compositions.
    Type: Application
    Filed: May 24, 2012
    Publication date: March 27, 2014
    Applicant: Nektar Therapeutics
    Inventors: Jennifer Riggs-Sauthier, Deborah H. Charych, Clark Norman Eid, Dennis G. Fry, Marina Konakova, Christine Frances Loehrlein
  • FGFR EXTRACELLULAR DOMAIN ACIDIC REGION MUTEINS
    Publication number: 20130004492
    Abstract: Fibroblast growth factor receptor (FGFR) extracellular domain (ECD) acidic region muteins that have been engineered to exhibit decreased tissue binding by increasing the number of acidic amino acid residues within the D1-D2 linker region are provided. Polynucleotides encoding FGFR ECD acidic region muteins are also provided. Methods of making FGFR ECD acidic region muteins, and methods of using such molecules to treat proliferative disorders, including cancers, disorders of angiogenesis, and macular degeneration, are also provided.
    Type: Application
    Filed: September 12, 2012
    Publication date: January 3, 2013
    Applicant: FIVE PRIME THERAPEUTIC INC.
    Inventors: Shannon Marshall, Deborah H. Charych, Ali Sadra
  • FGFR extracellular domain acidic region muteins
    Patent number: 8338569
    Abstract: Fibroblast growth factor receptor (FGFR) extracellular domain (ECD) acidic region muteins that have been engineered to exhibit decreased tissue binding by increasing the number of acidic amino acid residues within the D1-D2 linker region are provided. Polynucleotides encoding FGFR ECD acidic region muteins are also provided. Methods of making FGFR ECD acidic region muteins, and methods of using such molecules to treat proliferative disorders, including cancers, disorders of angiogenesis, and macular degeneration, are also provided.
    Type: Grant
    Filed: August 4, 2009
    Date of Patent: December 25, 2012
    Assignee: Five Prime Therapeutics, Inc.
    Inventors: Shannon Marshall, Deborah H. Charych, Ali Sadra
  • FGFR Extracellular Domain Acidic Region Muteins
    Publication number: 20100087627
    Abstract: Fibroblast growth factor receptor (FGFR) extracellular domain (ECD) acidic region muteins that have been engineered to exhibit decreased tissue binding by increasing the number of acidic amino acid residues within the D1-D2 linker region are provided. Polynucleotides encoding FGFR ECD acidic region muteins are also provided. Methods of making FGFR ECD acidic region muteins, and methods of using such molecules to treat proliferative disorders, including cancers, disorders of angiogenesis, and macular degeneration, are also provided.
    Type: Application
    Filed: August 4, 2009
    Publication date: April 8, 2010
    Inventors: Shannon Marshall, Deborah H. Charych, Ali Sadra
  • Sensitive and rapid detection of pathogenic organisms and toxins using fluorescent polymeric lipids
    Publication number: 20030129618
    Abstract: The present invention relates to methods and compositions for the detection of analytes using the fluorescence that occurs in polymeric material in response to selective binding of analytes to the polymeric materials. In particular, the present invention allows for the fluorescent detection of membrane modifying reactions and analytes responsible for such modifications and for the screening of reaction inhibitors.
    Type: Application
    Filed: August 9, 2002
    Publication date: July 10, 2003
    Applicant: Regents of the University of California
    Inventors: Mario Manuel Moronne, Deborah H. Charych, Jon O. Nagy
  • Sol-gel matrices for direct colorimetric detection of analytes
    Patent number: 6485987
    Abstract: The present invention relates to methods and compositions for the direct detection of analytes using color changes that occur in immobilized biopolymeric material in response to selective binding of analytes to their surface. In particular, the present invention provides methods and compositions related to the encapsulation of biopolymeric material into metal oxide glass using the sol-gel method.
    Type: Grant
    Filed: February 8, 2000
    Date of Patent: November 26, 2002
    Assignees: Regents of the University of California, Sandia Corporation
    Inventors: Deborah H. Charych, Darryl Sasaki, Stacey Yamanaka
  • Nucleic acid-coupled colorimetric analyte detectors
    Patent number: 6306598
    Abstract: The present invention relates to methods and compositions for the direct detection of analytes and membrane conformational changes through the detection of color changes in biopolymeric materials. In particular, the present invention provide for the direct colorimetric detection of analytes using nucleic acid ligands at surfaces of polydiacetylene liposomes and related molecular layer systems.
    Type: Grant
    Filed: June 21, 1999
    Date of Patent: October 23, 2001
    Assignee: Regents of the University of California
    Inventors: Deborah H. Charych, Ulrich Jonas
  • Sol-gel matrices for direct colorimetric detection of analytes
    Patent number: 6022748
    Abstract: The present invention relates to methods and compositions for the direct detection of analytes using color changes that occur in immobilized biopolymeric material in response to selective binding of analytes to their surface. In particular, the present invention provides methods and compositions related to the encapsulation of biopolymeric material into metal oxide glass using the sol-gel method.
    Type: Grant
    Filed: August 29, 1997
    Date of Patent: February 8, 2000
    Assignee: Sandia Corporation - New Mexico Regents of the University of California
    Inventors: Deborah H. Charych, Darryl Sasaki, Stacey Yamanaka
  • Growth of oriented crystals at polymerized membranes
    Patent number: 6017390
    Abstract: The present invention relates to methods and compositions for the growth and alignment of crystals at biopolymeric films. The methods and compositions of the present invention provide means to generate a variety of dense crystalline ceramic films, with totally aligned crystals, at low temperatures and pressures, suitable for use with polymer and plastic substrates.
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: January 25, 2000
    Assignee: The Regents of the University of California
    Inventors: Deborah H. Charych, Amir Berman