Patents by Inventor Deborah Hung

Deborah Hung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRISPR EFFECTOR SYSTEM BASED DIAGNOSTICS
    Publication number: 20180274017
    Abstract: The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.
    Type: Application
    Filed: March 15, 2018
    Publication date: September 27, 2018
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE GENERAL HOSPITAL CORPORATION
    Inventors: Omar ABUDAYYEH, James Joseph COLLINS, Jonathan GOOTENBERG, Feng ZHANG, Eric S. LANDER, Roby BHATTACHARYYA, Deborah HUNG
  • Rapid phenotypic diagnosis of pathogens and drug resistance using transcriptional expression signatures
    Patent number: 9885088
    Abstract: The specification relates generally to methods of detecting, diagnosing, and/or identifying pathogens, e.g., infectious disease pathogens and determining their drug sensitivity and appropriate methods of treatment. This invention also relates generally to methods of monitoring pathogen infection in individual subjects as well as larger populations of subjects.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: February 6, 2018
    Assignees: The Broad Institute, Inc., The General Hospital Corporation, The Brigham and Women's Hospital, Inc.
    Inventors: Deborah Hung, James Gomez, Amy Barczak
  • COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS
    Publication number: 20170327481
    Abstract: The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof:
    Type: Application
    Filed: May 31, 2017
    Publication date: November 16, 2017
    Inventors: Deborah Hung, Sarah Stanley, Tomohiko Kawate, Noriakie Iwase, Motohisa Shimizu
  • SUBSTITUTED AMINOTHIAZOLES FOR THE TREATMENT OF TUBERCULOSIS
    Publication number: 20170305895
    Abstract: Disclosed ore substituted aminothiazoles, which can be used for, among other things, the treatment of tuberculosis, pharmaceutical compositions containing the same, and methods of using the same.
    Type: Application
    Filed: March 23, 2017
    Publication date: October 26, 2017
    Inventors: Deborah Hung, Michael Serrano-Wu, Sarah Grant, Tomohiko Kawate
  • Compounds for the treatment of mycobacterial infections
    Patent number: 9682064
    Abstract: The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof:
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: June 20, 2017
    Assignees: The Broad Institute, Inc., Massachusetts General Hospital
    Inventors: Deborah Hung, Sarah Stanley, Tomohiko Kawate, Noriakie Iwase, Motohisa Shimizu
  • COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS
    Publication number: 20170014378
    Abstract: The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof:
    Type: Application
    Filed: July 21, 2016
    Publication date: January 19, 2017
    Inventors: Deborah Hung, Sarah Stanley, Tomohiko Kawate, Noriakie Iwase, Motohisa Shimizu
  • Compounds for the treatment of mycobacterial infections
    Patent number: 9416121
    Abstract: The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof:
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: August 16, 2016
    Assignees: The Broad Institute, Inc., Massachusetts General Hospital
    Inventors: Deborah Hung, Sarah Stanley, Tomohiko Kawate, Noriakie Iwase, Motohisa Shimizu
  • COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS
    Publication number: 20160031870
    Abstract: Disclosed are compounds that can be used for treating tuberculosis.
    Type: Application
    Filed: March 12, 2014
    Publication date: February 4, 2016
    Inventors: Timothy A. Lewis, Sivaraman Dandapani, Deborah Hung, Benito Munoz, Partha Nag, Sarah Grant, Tomohiko Kawate
  • SUBSTITUTED AMINOTHIAZOLES FOR THE TREATMENT OF TUBERCULOSIS
    Publication number: 20160031874
    Abstract: Disclosed are substituted aminothiazoles, which can be used for, among other things, the treatment of tuberculosis, pharmaceutical compositions containing the same, and methods of using the same.
    Type: Application
    Filed: March 13, 2014
    Publication date: February 4, 2016
    Inventors: Deborah Hung, Michael Serrano-Wu, Sarah Grant, Tomohiko Kawate
  • Methods of Diagnosing Infectious Disease Pathogens and Their Drug Sensitivity
    Publication number: 20150203900
    Abstract: The specification relates generally to methods of detecting, diagnosing, and/or identifying pathogens, e.g., infectious disease pathogens and determining their drug sensitivity and appropriate methods of treatment. This invention also relates generally to methods of monitoring pathogen infection in individual subjects as well as larger populations of subjects.
    Type: Application
    Filed: March 9, 2015
    Publication date: July 23, 2015
    Inventors: Deborah Hung, Amy Barczak, James Gomez, Andrew B. Onderdonk, Lisa Cosimi, Rob Nicol, Mark Borowsky
  • COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS
    Publication number: 20140296232
    Abstract: The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof:
    Type: Application
    Filed: March 27, 2014
    Publication date: October 2, 2014
    Applicants: Massachusetts General Hospital, The Broad Institute, Inc.
    Inventors: Deborah Hung, Sarah Stanley, Tomohiko Kawate, Noriakie Iwase, Motohisa Shimizu
  • RAPID PHENOTYPIC DIAGNOSIS OF PATHOGENS AND DRUG RESISTANCE USING TRANSCRIPTIONAL EXPRESSION SIGNATURES
    Publication number: 20130190196
    Abstract: The specification relates generally to methods of detecting, diagnosing, and/or identifying pathogens, e.g., infectious disease pathogens and determining their drug sensitivity and appropriate methods of treatment. This invention also relates generally to methods of monitoring pathogen infection in individual subjects as well as larger populations of subjects.
    Type: Application
    Filed: February 24, 2011
    Publication date: July 25, 2013
    Inventors: Andrew B. Onderdonk, Amy Barczak, Deborah Hung, James Gomez, Lisa Cosimi, Rob Nicol, Mark Borowsky