Abstract: The present disclosure provides botanicals and/or biotin or analogs thereof, that proliferate or reduce stem cell populations and activate or attenuate Wat/?-Catenin signaling and thus treat or prevent diseases related to signal transduction. In particular, the disclosure provides Botanicals and Biotin or analogs thereof, that proliferate or reduce stem cell populations and activate or attenuate Wnt/?-Catenin signaling in tissues expressing Wnt1OB including, adipose, adrenal, artery, blood, bone marrow, brain, breast, cervix, colon, esophagus, heart, intestine, kidney, liver, lung, muscle, ovary, pituitary, prostate, skin, spleen, testis, thyroid, uterus and vagina. The present compositions and methods are particularly suited to growing and melanizing hair.

Abstract: Methods and apparatus are provided for validating configuration data in a switch. An error is detected if the configuration data fails to comply with one or more rules; and a user is presented with an interface that allows the user to correct the error. The rules may include one or more syntactic rules or conflict rules (or both). In the case of a simple error, the user is presented with an error indication with a smart error link. In the case of a conflict error, the user is presented with an error indication that identifies the conflicting endpoints and optionally allows the user to correct at least one conflicting endpoint. The configuration data is revalidated after a change is made by a user. Changes are propagated to affected data objects. A number of error types may be automatically updated.

Abstract: A method for combined cycle electrical power generation comprises utilizing a coal hydrogenator 2 and a reactor 1 for producing from a methane-rich gas a hot crude hydrogen-containing gas which is fed directly (apart from an optional quenching stage) to the coal hydrogenator. The coal hydrogenator produces gaseous and liquid products which are combusted to drive a gas turbine 5 which drives an electrical generator 6. The hydrogenator also produces char which is combusted in a boiler 10 to form steam to drive a steam turbine 11 which, in turn, drives another electrical generator 12. Such direct use of the hot crude gas avoids having to preheat hydrogen-containing feed to the hydrogenator.