Abstract: A carrying case for protecting heat sensitive materials includes a first portion, a second portion, and a closure device. The closure device seals the first portion to the second portion. Each portion includes a retainer which contains a phase change material. The retainer is covered on an outside with an insulation layer. The insulation layer and retainer are preferably covered with a fabric layer. A second embodiment of a carrying case for protecting heat sensitive materials includes a cover, a container, and a closure device. The walls of the container and cover preferably include a retainer which contains phase change material, an insulation layer, an outer fabric layer, and an inner fabric layer. A third embodiment of a carrying case for protecting heat sensitive materials includes a pouch which is sealable with a closure device. The wall of the pouch preferably includes a fabric outer layer, a flexible foam outer layer, a phase change layer, a flexible foam inner layer, and a fabric inner layer.