Patents by Inventor Deborah K. Lieu

Deborah K. Lieu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ELECTROPHYSIOLOGICALLY MATURE CARDIOMYOCYTES AND METHODS FOR MAKING SAME
    Publication number: 20200277594
    Abstract: Methods to prepare electrophysiology mature cells from immature cells are provided, without the need for genetic manipulation.
    Type: Application
    Filed: October 4, 2019
    Publication date: September 3, 2020
    Inventors: Ronald A. Li, Deborah K. Lieu
  • Electrophysiologically mature cardiomyocytes and methods for making same
    Patent number: 10087436
    Abstract: Methods to prepare electrophysiology mature cells from immature cells are provided, without the need for genetic manipulation.
    Type: Grant
    Filed: February 5, 2015
    Date of Patent: October 2, 2018
    Assignee: The Regents of the University of California
    Inventors: Ronald A. Li, Deborah K. Lieu
  • Compositions and Methods for Improving the Functional Efficacy of Stem Cell-Derived Cardiomyocytes
    Publication number: 20160045555
    Abstract: An isolated stem cell that has been modified to provide, enhance orcontain the functional characteristics of the sarcoplasmic reticulum (SR). The isolated stem cells are modified in one or more of the following manners: by expressing a calcium channel protein; by expressing a calcium pump protein such as the sarcro/endoplasmic reticulum Ca2+-ATPase (SERCA) protein; by inhibiting or downregulating expression of the Na+/Ca2+ exchanger (NCX) protein; by expressing a calcium handling protein; by expressing a transverse (t)-tubule; and/or by expressing a transverse (t)-tubule biogenic protein. After the cell has been modified, it may be expanded to a substantially homogenous population of these cells or alternatively, differentiated to a more mature cell type. Compositions containing these cells and population of cells are also provided by this invention.
    Type: Application
    Filed: June 1, 2015
    Publication date: February 18, 2016
    Inventors: Ronald Li, Chung-wah Siu, Deborah K. Lieu, Jing Liu
  • ELECTROPHYSIOLOGICALLY MATURE CARDIOMYOCYTES AND METHODS FOR MAKING SAME
    Publication number: 20150218549
    Abstract: Methods to prepare electrophysiology mature cells from immature cells are provided, without the need for genetic manipulation.
    Type: Application
    Filed: February 5, 2015
    Publication date: August 6, 2015
    Inventors: Ronald A. Li, Deborah K. Lieu
  • Compositions and methods for improving the functional efficacy of stem cell-derived cardiomyocytes
    Patent number: 9045731
    Abstract: This invention provides an isolated stem cell that has been modified to provide, enhance or contain the functional characteristics of the sarcoplasmic reticulum (SR). The isolated stem cells are modified in one or more of the following manners: by expressing a calcium channel protein; by expressing a calcium pump protein such as the sarcro/endoplasmic reticulum Ca2+-ATPase (SERCA) protein; by inhibiting or downregulating expression of the Na+/Ca+ exchanger (NCX) protein; by expressing a calcium handling protein; by expressing a transverse (t-tubule; and/or by expressing a transverse (t-tubule biogenic protein. After the cell has been modified, it may be expanded to a substantially homogenous population of these cells or alternatively, differentiated to a more mature cell type. Compositions containing these cells and population of cells are also provided by this invention.
    Type: Grant
    Filed: September 11, 2008
    Date of Patent: June 2, 2015
    Assignee: The Regents of the University of California
    Inventors: Ronald Li, Chung-wah Siu, Deborah K. Lieu, Jing Liu
  • Compositions and Methods for Improving the Functional Efficacy of Stem Cell-Derived Cardiomyocytes
    Publication number: 20120014924
    Abstract: This invention provides an isolated stem cell modified to provide, enhance or contain the functional characteristics of the sarcoplasmic reticulum (SR) The isolated stem cells are modified by expressing a calcium channel protein, by expressing a calcium pump protein such as the sarcro/endoplasmic reticulum Ca2+-ATPase (SERCA) protein, by inhibiting or downregulating expression of the Na+/Ca2+ exchanger (NCX) protein, by expressing a calcium handling protein, by expressing a transverse (t)-tubule, and/or by expressing a transverse (t)-tubule biogenic protein The modified cells may be expanded to a substantially homogenous population of these cells or differentiated to a more mature cell type Compositions are also provided The cells and compositions can be administered to a host and used to regenerate cardiac tissue, improve cardiac function, restore action potential of cardiac tissue, and treat or prevent cardiac malfunction Use for diagnostic screening of therapeutic candidates is also provided
    Type: Application
    Filed: September 11, 2008
    Publication date: January 19, 2012
    Inventors: Ronald Li, Chung-wah Siu, Deborah K. Lieu, Jing Liu