Patents by Inventor Deborah Kilpatrick
Deborah Kilpatrick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9358268Abstract: A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.Type: GrantFiled: June 9, 2014Date of Patent: June 7, 2016Assignee: Abbott Cardiovascular Systems Inc.Inventors: Deborah Kilpatrick, Syed Faiyaz Ahmed Hossainy, Irina Astafieva, Florian N. Ludwig, Paul M. Consigny, Jeffrey T. Ellis, Florencia Lim
-
Publication number: 20140287033Abstract: A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.Type: ApplicationFiled: June 9, 2014Publication date: September 25, 2014Inventors: Deborah Kilpatrick, Syed Faiyaz Ahmed Hossainy, Irina Astafieva, Florian N. Ludwig, Paul M. Consigny, Jeffrey T. Ellis, Florencia Lim
-
Patent number: 8785382Abstract: A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.Type: GrantFiled: March 30, 2007Date of Patent: July 22, 2014Assignee: Abbott Cardiovascular Systems Inc.Inventors: Deborah Kilpatrick, Syed Faiyaz Ahmed Hossainy, Irina Astafieva, Florian N. Ludwig, Paul M. Consigny, Jeffrey T. Ellis, Florencia Lim
-
Patent number: 8652194Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque. In an alternative embodiment, the apparatus has an expandable tube attached to the inner surface of a stent, and a layer of endothelial cells seeded on the inner surface of the expandable tube. The expandable tube shields a vulnerable plaque from a body lumen.Type: GrantFiled: March 23, 2006Date of Patent: February 18, 2014Assignee: Abbott Cardiovascular Systems Inc.Inventors: Deborah Kilpatrick, Murthy Simhambhatla, Santosh Prabhu, Shawn Chin Quee
-
Patent number: 8613764Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque. In an alternative embodiment, the apparatus has an expandable tube attached to the inner surface of a stent, and a layer of endothelial cells seeded on the inner surface of the expandable tube. The expandable tube shields a vulnerable plaque from a body lumen.Type: GrantFiled: January 31, 2008Date of Patent: December 24, 2013Assignee: Abbott Cardiovascular Systems Inc.Inventors: Deborah Kilpatrick, Murthy Simhambhatla, Santosh Prabhu, Shawn Chin Quee
-
Patent number: 8017140Abstract: Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.Type: GrantFiled: May 21, 2007Date of Patent: September 13, 2011Assignee: Advanced Cardiovascular System, Inc.Inventors: Syed Faiyaz Ahmed Hossainy, Gordon Stewart, Deborah Kilpatrick, Jeffrey Ellis, Gene Park, Gina Zhang, Paul Consigny, Yiwen Tang
-
Patent number: 7783338Abstract: An apparatus and method to perform therapeutic treatment and diagnosis of a patient's vasculature through the use of an intravascular device having an optical fiber disposed therein. In an embodiment, the apparatus includes an intravascular device to perform a therapeutic treatment and at least one optical fiber disposed through the intravascular device. The optical fiber is configured to provide diagnostic information before, during, and after the therapeutic treatment. In an embodiment, diagnostic information includes vessel and blood characteristics such as hemodynamic characteristics, hematological parameters related to blood and blood components, and thermal parameters of the vasculature.Type: GrantFiled: January 9, 2008Date of Patent: August 24, 2010Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Robert Ainsworth, Deborah Kilpatrick, Jeong S. Lee, Bridget A. Hurley, Jeffrey T. Ellis
-
Publication number: 20090270973Abstract: An intravascular stent assembly for implantation in a body lumen, such as a coronary artery, is designed to treat a lesion with vulnerable plaque by reducing the fibrous cap stresses. A polymeric sleeve having first and second ends interconnects a first metallic stent and a second metallic stent. The first end is bonded to a distal end region of the first stent and the second end to a proximal end region of the second stent. The polymeric sleeve can be loaded with a therapeutic drug or agent to further control local thrombosis and/or induce healing if the plaque fibrous cap ruptures during or after implantation. Methods of making an intravascular stent assembly for the treatment of vulnerable plaque are also provided.Type: ApplicationFiled: July 7, 2009Publication date: October 29, 2009Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC.Inventors: Yung-Ming Chen, Christopher Feezor, Deborah Kilpatrick, Santosh Prabhu
-
Patent number: 7572286Abstract: An intravascular stent assembly for implantation in a body lumen, such as a coronary artery, is designed to treat a lesion with vulnerable plaque by reducing the fibrous cap stresses. A polymeric sleeve having first and second ends interconnects a first metallic stent and a second metallic stent. The first end is bonded to a distal end region of the first stent and the second end to a proximal end region of the second stent. The polymeric sleeve can be loaded with a therapeutic drug or agent to further control local thrombosis and/or induce healing if the plaque fibrous cap ruptures during or after implantation. Methods of making an intravascular stent assembly for the treatment of vulnerable plaque are also provided.Type: GrantFiled: May 13, 2002Date of Patent: August 11, 2009Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Yung-Ming Chen, Christopher Feezor, Deborah Kilpatrick, Santosh Prabhu
-
Patent number: 7532920Abstract: Apparatus and method to perform therapeutic treatment and diagnosis of a patient's vasculature through the use of an intravascular device having an optical fiber disposed therein. In an embodiment of this invention, the apparatus includes a therapeutic guidewire and at least one optical fiber disposed through the therapeutic guidewire, the optical fiber capable of providing diagnostic information before, during, and after the therapeutic treatment. In an embodiment, diagnostic information includes vessel and blood characteristics such as hemodynamic characteristics, hematological parameters related to blood and blood components, and thermal parameters of the vasculature.Type: GrantFiled: May 31, 2001Date of Patent: May 12, 2009Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Robert D. Ainsworth, Deborah Kilpatrick, Jeong S. Lee, Bridget A. Hurley, Jeffrey T. Ellis, Marc Jalisi, Florencia Lim, Chi Long
-
Publication number: 20080139897Abstract: An apparatus and method to perform therapeutic treatment and diagnosis of a patient's vasculature through the use of an intravascular device having an optical fiber disposed therein. In an embodiment, the apparatus includes an intravascular device to perform a therapeutic treatment and at least one optical fiber disposed through the intravascular device. The optical fiber is configured to provide diagnostic information before, during, and after the therapeutic treatment. In an embodiment, diagnostic information includes vessel and blood characteristics such as hemodynamic characteristics, hematological parameters related to blood and blood components, and thermal parameters of the vasculature.Type: ApplicationFiled: January 9, 2008Publication date: June 12, 2008Inventors: Robert D. Ainsworth, Deborah Kilpatrick, Jeong S. Lee, Bridget A. Hurley, Jeffrey T. Ellis
-
Publication number: 20080125851Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque. In an alternative embodiment, the apparatus has an expandable tube attached to the inner surface of a stent, and a layer of endothelial cells seeded on the inner surface of the expandable tube. The expandable tube shields a vulnerable plaque from a body lumen.Type: ApplicationFiled: January 31, 2008Publication date: May 29, 2008Inventors: Deborah Kilpatrick, Murthy Simhambhatla, Santosh Prabhu, Shawn Chin Quee
-
Patent number: 7329223Abstract: An apparatus and method to perform therapeutic treatment and diagnosis of a patient's vasculature through the use of an intravascular device having an optical fiber disposed therein. In an embodiment, the apparatus includes an intravascular device to perform a therapeutic treatment and at least one optical fiber disposed through the intravascular device. The optical fiber is configured to provide diagnostic information before, during, and after the therapeutic treatment. In an embodiment, diagnostic information includes vessel and blood characteristics such as hemodynamic characteristics, hematological parameters related to blood and blood components, and thermal parameters of the vasculature.Type: GrantFiled: May 31, 2001Date of Patent: February 12, 2008Assignee: Abbott Cardiovascular Systems Inc.Inventors: Robert Ainsworth, Deborah Kilpatrick, Jeong S. Lee, Bridget A. Hurley, Jeffrey T. Ellis
-
Patent number: 7326238Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque. In an alternative embodiment, the apparatus has an expandable tube attached to the inner surface of a stent, and a layer of endothelial cells seeded on the inner surface of the expandable tube. The expandable tube shields a vulnerable plaque from a body lumen.Type: GrantFiled: September 30, 2002Date of Patent: February 5, 2008Assignee: Abbott Cardiovascular Systems Inc.Inventors: Deborah Kilpatrick, Murthy Simhambhatla, Santosh Prabhu, Shawn Chin Quee
-
Publication number: 20070269484Abstract: Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.Type: ApplicationFiled: May 21, 2007Publication date: November 22, 2007Inventors: Syed Hossainy, Gordon Stewart, Deborah Kilpatrick, Jeffrey Ellis, Gene Park, Gina Zhang, Paul Consigny, Yiwen Tang
-
Publication number: 20070232539Abstract: A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.Type: ApplicationFiled: March 30, 2007Publication date: October 4, 2007Inventors: Deborah Kilpatrick, Syed Faiyaz Ahmed Hossainy, Irina Astafieva, Florian N. Ludwig, Paul M. Consigny, Jeffrey T. Ellis, Florencia Lim
-
Publication number: 20060265043Abstract: Various apparatuses and methods are described to treat vulnerable plaque with the use of combination drug therapy. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a therapeutic or biologically active agent to stabilize a vulnerable plaque. In another embodiment, a drug eluting stent is delivered and deployed in conjunction with a second apparatus that delivers drug in pressurized retrograde perfusion. Still another embodiment uses a uniquely shaped balloon to deploy a stent while utilizing a drug infusion needle to inject drug into the vessel wall through a hollow guide wire.Type: ApplicationFiled: March 24, 2006Publication date: November 23, 2006Inventors: Evgenia Mandrusov, Deborah Kilpatrick, Murthy Simhambhatla, Syed Hossainy, Jessica Chiu, Mina Chow, Eugene Michal, Charles Claude, William Webler
-
Publication number: 20060135943Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a biologically active agent to stabilize a vulnerable plaque.Type: ApplicationFiled: November 17, 2005Publication date: June 22, 2006Inventors: Evgenia Mandrusov, Deborah Kilpatrick, Murthy Simhambhatla, Syed Hossainy
-
Publication number: 20060129041Abstract: A guidewire with a sensor which can detect NO and/or superoxide levels is disclosed. This invention can be useful for in vivo analysis of vascular health.Type: ApplicationFiled: February 3, 2006Publication date: June 15, 2006Inventors: Jeffrey Ellis, Robert Ainsworth, Deborah Kilpatrick, Alex Tilson, Bridget Hurley
-
Patent number: 7008411Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a biologically active agent to stabilize a vulnerable plaque.Type: GrantFiled: September 30, 2002Date of Patent: March 7, 2006Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Evgenia Mandrusov, Deborah Kilpatrick, Murthy Simhambhatla, Syed Hossainy