Patents by Inventor Deborah Krakow

Deborah Krakow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATING RESPIRATORY INSUFFICIENCY
    Publication number: 20220105061
    Abstract: The present invention relates to compositions of chemical chaperone and methods of using the same to treat endoplasmic reticulum stress including pulmonary or cardiac insufficiency in diseases such as osteogenesis imperfecta.
    Type: Application
    Filed: March 9, 2020
    Publication date: April 7, 2022
    Applicant: The Regents of the University of California
    Inventors: Ivan J. DURAN JIMENEZ, Fabiana CSUKASI CABRERA, Daniel H. COHN, Deborah KRAKOW
  • 3-phosphoadenosine-5-phosphosulfate (PAPS) synthetase proteins and methods for treating osteoarthritic disorders
    Patent number: 6818428
    Abstract: Disclosed are isolated polynucleotides containing nucleic acid segments encoding human or murine ATP sulfurylase/APS kinase, also known as PAPS synthetase (PAPSS), particularly PAPSS2 and Papss2 proteins. Also disclosed are nucleic acid constructs, including vectors, probes, primers, and primer pairs containing novel PAPSS2 and Papss2 gene sequences. A genetically modified vertebrate cell containing a nucleic acid construct of the present invention and a non-human vertebrate comprising the cell are also disclosed. Based on the present PAPSS2-specific polynucleotides and nucleic acid constructs, are genetic testing kits and methods for diagnosing spondyloepimetaphyseal dysplasia (SEMD) in a human subject, of identifying a human carrier of an heritable allele associated with SEMD, and of gene therapy or protein therapy for treating a human subject having an osteoarthritic disorder, which is caused or aggravated by deficient enzymatic sulfation activity.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: November 16, 2004
    Assignee: Cedars Sinai Medical Center
    Inventors: Daniel H. Cohn, Muhammad Faiyaz-Ul-Haque, Lily King, Deborah Krakow
  • Genetic marker for spondyloepimetaphyseal dysplasia
    Publication number: 20030195162
    Abstract: Disclosed are isolated polynucleotides containing nucleic acid segments encoding human or murine ATP sulfurylase/APS kinase, also known as PAPS synthetase (PAPSS), particularly PAPSS2 and Papss2 proteins. Also disclosed are nucleic acid constructs, including vectors, probes, primers, and primer pairs containing novel PAPSS2 and Papss2 gene sequences. A genetically modified vertebrate cell containing a nucleic acid construct of the present invention and a non-human vertebrate comprising the cell are also disclosed. Based on the present PAPSS2-specific polynucleotides and nucleic acid constructs, are genetic testing kits and methods for diagnosing spondyloepimetaphyseal dysplasia (SEMD) in a human subject, of identifying a human carrier of an heritable allele associated with SEMD, and of gene therapy or protein therapy for treating a human subject having an osteoarthritic disorder, which is caused or aggravated by deficient enzymatic sulfation activity.
    Type: Application
    Filed: July 2, 2001
    Publication date: October 16, 2003
    Inventors: Daniel H. Cohn, Muhammad Faiyaz-Ul-Haque, Lily King, Deborah Krakow