Patents by Inventor Deborah L. Blacker

Deborah L. Blacker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alpha-2-macroglobulin isotype diagnostic test for Alzheimer's disease
    Publication number: 20020028462
    Abstract: The disclosed invention relates to a diagnostic method for Alzheimer's disease based on genotyping the Alpha-2-Macroglobulin locus. A statistically significant correlation was found between inheritance of particular alleles of the Alpha-2-Macroglobulin gene and the occurrence of Alzheimer's disease. The diagnostic method involves the isolation of nucleic acid from an individual and subsequent genotyping by means such as sequencing or restriction fragment length polymorphism analysis. The invention also provides a means of genotype analysis through protein isotyping Alpha-2-Macroglobulin variant proteins. Finally, kits for nucleic acid analysis or protein analysis are taught.
    Type: Application
    Filed: August 10, 2001
    Publication date: March 7, 2002
    Applicant: The General Hospital Corporation
    Inventors: Rudolph E. Tanzi, Deborah L. Blacker
  • Alpha-2-macroglobulin diagnostic test
    Patent number: 6342350
    Abstract: The disclosed invention relates to a diagnostic method for Alzheimer's disease based on genotyping the Alpha-2-Macroglobulin locus. A statistically significant correlation was found between inheritance of particular alleles of the Alpha-2-Macroglobulin gene and the occurrence of Alzheimer's disease. The diagnostic method involves the isolation of nucleic acid from an individual and subsequent genotyping by means such as sequencing or restriction fragment length polymorphism analysis. The invention also provides a means of genotype analysis through protein isotyping Alpha-2-Macroglobulin variant proteins. Finally, kits for nucleic acid analysis or protein analysis are taught.
    Type: Grant
    Filed: September 4, 1998
    Date of Patent: January 29, 2002
    Assignee: The General Hospital Corporation
    Inventors: Rudolph E. Tanzi, Bradley T. Hyman, George W. Rebeck, Deborah L. Blacker