Patents by Inventor Deborah L. Bryan

Deborah L. Bryan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anthranilamide inhibitors of aurora kinase
    Patent number: 7884098
    Abstract: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; wherein R1, R1? R2, R3, R4, R5, r and s are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: February 8, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Jeffrey Michael Axten, Deborah L. Bryan, David Harold Drewry, Thomas H Faitg, Timothy Francis Gallagher, Neil W Johnson, Jiri Kasparec, Jeffrey M Ralph, Domingos J. Silva
  • ANTHRANILAMIDE INHIBITORS OF AURORA KINASE
    Publication number: 20100016318
    Abstract: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; wherein R1, R1? R2, R3, R4, R5, r and s are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
    Type: Application
    Filed: January 25, 2008
    Publication date: January 21, 2010
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Jeffrey Michael Axten, Deborah L. Bryan, David Harold Drewry, Thomas H. Faitg, Timothy Francis Gallagher, Neil W. Johnson, Jiri Kasparec, Jeffrey M. Ralph, Domingos J. Silva
  • Anthranilamide inhibitors of Aurora kinase
    Patent number: 7625903
    Abstract: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; where R1, R2, R3, R4, r and s are as previously defined. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: December 1, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Neil W. Johnson, Deborah L. Bryan
  • Compounds
    Patent number: 7449484
    Abstract: The present invention is directed to novel compounds of Formula (I) for use in the treatment of diseases in a mammal, in which inappropriate, excessive or undesirable angiogenesis has occurred and/or where excessive Tie2 receptor activity has occurred.
    Type: Grant
    Filed: March 23, 2006
    Date of Patent: November 11, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Deborah L. Bryan
  • ANTHRANILAMIDE INHIBITORS OF AURORA KINASE
    Publication number: 20080182852
    Abstract: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; where R1, R2, R3, R4, r and s are as previously defined. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
    Type: Application
    Filed: January 25, 2008
    Publication date: July 31, 2008
    Inventors: Neil W. Johnson, Deborah L. Bryan
  • Quinoline inhibitors of hyaki and hyak3 kinases
    Patent number: 7087758
    Abstract: This invention relates to novel quinoline inhibitors of hYAK1 and hYAK3 kinases and pharmaceutically acceptable salts, hydrates or solvates thereof, pharmaceutical compositions thereof, and methods of treatment of diseases in which an excessive amount of either such kinase is a factor.
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: August 8, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: Deborah L. Bryan, Joelle L. Burgess, James F. Callahan
  • Novel compounds
    Publication number: 20040053943
    Abstract: The present invention is directed to novel compounds of Formula (I) for use in the treatment of diseases in a mammal, in which inappropriate, excessive or undesirable angiogenesis has occurred and/or where excessive Tie2 receptor activity has occurred.
    Type: Application
    Filed: May 20, 2003
    Publication date: March 18, 2004
    Inventors: Jerry L. Adams, Deborah L. Bryan
  • Endothelin receptor antagonists
    Patent number: 5559105
    Abstract: A compound of formula: ##STR1##
    Type: Grant
    Filed: January 17, 1995
    Date of Patent: September 24, 1996
    Assignee: SmithKline Beecham Corporation
    Inventors: Deborah L. Bryan, John D. Elliott
  • Process for the preparation of esters of leukotriene A
    Patent number: 4440939
    Abstract: Esters of leukotriene A are conveniently prepared by reacting 9-oxo-5,6-trans-epoxynon-7(E)-enoates with 11-triphenylphosphoranylidene undec-6(Z),9(Z)-diene. Esters of leukotriene-A are useful intermediates in the synthesis of naturally occurring leukotrienes, which have been shown to be potent broncho-constricting substances. Novel intermediates to the esters of leukotriene A, 9-oxo-5,6-transepoxynon-7(E)-enoates and 7-oxo-5,6-trans-epoxyheptanoates, are disclosed.
    Type: Grant
    Filed: November 4, 1982
    Date of Patent: April 3, 1984
    Assignee: SmithKline Beckman Corporation
    Inventors: John G. Gleason, Charles M. Kinzig, Deborah L. Bryan
  • Process for the preparation of esters of leukotriene A
    Patent number: 4387239
    Abstract: Esters of leukotriene A are conveniently prepared by reacting 9-oxo-5,6-trans-epoxynon-7(E)-enoates with 11-triphenylphosphoranylidene undec-6(Z),9(Z)-diene. Esters of leukotriene-A are useful intermediates in the synthesis of naturally occurring leukotrienes, which have been shown to be potent broncho-constricting substances. Novel intermediates to the esters of leukotriene A. 9-oxo-5,6-trans-epoxynon-7(E)-enoates and 7-oxo-5,6-trans-epoxyheptanoates, are disclosed.
    Type: Grant
    Filed: December 22, 1981
    Date of Patent: June 7, 1983
    Assignee: SmithKline Beckman Corporation
    Inventors: John G. Gleason, Charles M. Kinzig, Deborah L. Bryan
  • Process for the preparation of esters of leukotriene A
    Patent number: 4352757
    Abstract: Esters of leukotriene A are conveniently prepared by reacting 9-oxo-5,6-trans-epoxynon-7(E)-enoates with 11-triphenylphosphoranylidene undec-6(Z),9(Z)-diene. Esters of leukotriene-A are useful intermediates in the synthesis of naturally occurring leukotrienes, which have been shown to be potent broncho-constricting substances. Novel intermediates to the esters of leukotriene A, 9-oxo-5,6-transepoxynon-7(E)-enoates and 7-oxo-5,6-transepoxyheptanoates, are disclosed.
    Type: Grant
    Filed: February 2, 1981
    Date of Patent: October 5, 1982
    Assignee: SmithKline Beckman Corporation
    Inventors: John G. Gleason, Charles M. Kinzig, Deborah L. Bryan