Patents by Inventor Deborah L. Zink

Deborah L. Zink has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Extracts from kibdelos porangium as antibacterial agents
    Patent number: 9126983
    Abstract: The present invention relates to novel compounds of formulae (I) and (II) and pharmaceutically acceptable salts thereof that are useful in the treatment and/or prevention of human and animal bacterial infections and associated diseases and conditions; compositions containing such compounds; derivation of such compounds by fermentation and isolation, partial synthesis and total synthesis; methods of inhibiting bacterial growth; methods of treating, preventing or controlling bacterial infection; biologically pure cultures of bacterial strains from which such compounds may be produced; and processes for preparing compositions containing such compounds.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: September 8, 2015
    Assignees: Merck Sharp & Dohme Corp., Merck Sharp & Dohme de Espana SA
    Inventors: Sheo Singh, Jon D. Polishook, Deborah L. Zink, Olga Genilloud, Michael Goetz, Francisca Vicente, David Brian Olsen, Scott Knoble Smith
  • Extracts From Kibdelos Porangium As Antibacterial Agents
    Publication number: 20130005673
    Abstract: The present invention relates to novel compounds of formulae (I) and (II) and pharmaceutically acceptable salts thereof that are useful in the treatment and/or prevention of human and animal bacterial infections and associated diseases and conditions; compositions containing such compounds; derivation of such compounds by fermentation and isolation, partial synthesis and total synthesis; methods of inhibiting bacterial growth; methods of treating, preventing or controlling bacterial infection; biologically pure cultures of bacterial strains from which such compounds may be produced; and processes for preparing compositions containing such compounds.
    Type: Application
    Filed: December 17, 2010
    Publication date: January 3, 2013
    Inventors: Sheo Singh, Jon D. Polishook, Deborah L. Zink, Olga Genilloud, Michael Goetz, Francisca Vicente, David Brian Olsen, Scott Knoble Smith
  • HIV integrase inhibitors
    Patent number: 6403347
    Abstract: Natural products such as certain chaetochromins are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
    Type: Grant
    Filed: October 25, 1999
    Date of Patent: June 11, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Gerald F. Bills, Russell B. Lingham, Ali Shafiee, Keith C. Silverman, Sheo Bux Singh, Deborah L. Zink, Fernando Pelaez, Ana M. Teran
  • HIV integrase inhibitors
    Patent number: 6395743
    Abstract: Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines are described. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. The culture Actinoplanes sp. MA7220 (ATCC 202188) is also disclosed, as well as processes for making compounds of the present invention employing the culture.
    Type: Grant
    Filed: October 12, 2000
    Date of Patent: May 28, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Brian Heimbuch, Sheo Singh, Deborah L. Zink, Magda Gagliardi, Olga Genilloud, Ana Teran
  • HIV INTEGRASE INHIBITORS
    Publication number: 20010014748
    Abstract: Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines are described. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. Further, the culture Fusarium sp., MF6381 (ATCC 74469) is also disclosed, as well as processes for making compounds of structural formula I employing the culture Fusarium sp., MF6381 (ATCC 74469).
    Type: Application
    Filed: December 13, 1999
    Publication date: August 16, 2001
    Inventors: SHEO BUX SINGH, DEBORAH L. ZINK, DARIA JEAN HAZUDA, PETER J. FELOCK, JON DAVID POLISHOOK, ANNE W. DOMBROWSKI
  • HIV integrase inhibitors
    Patent number: 6271402
    Abstract: Compound of formula I: wherein the R groups are as defined by the specification. The compounds are useful in the inhibition of HIV integrase, the treatment of infection of HIV and treatment of AIDS.
    Type: Grant
    Filed: December 13, 1999
    Date of Patent: August 7, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Sheo Bux Singh, Deborah L. Zink, Daria Jean Hazuda, Peter J. Felock, Anne W. Dombrowski
  • HIV integrase inhibitors
    Patent number: 6245806
    Abstract: Novel tetracyclic aromatic ketones are natural product compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. Further, the novel fungal cultures MF6388 (ATCC 74478), Sterile Fungus, and MF6591 (ATCC 74477), Ascochyta sp. are also disclosed. Further, the cultures Sterile Fungus MF6388 (ATCC 74478) and Ascochyta sp. MF6591 (ATCC 74477) are also disclosed, as well as processes for making compounds of the present invention employing the cultures.
    Type: Grant
    Filed: July 25, 2000
    Date of Patent: June 12, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Anne Dombrowski, Sheo Singh, Deborah L. Zink, Ana Teran, Fernando Pelaez, Daria Hazuda
  • HIV integrase inhibitors
    Patent number: 6124327
    Abstract: Natural products such as certain dimerized hydroxyphenylundecanes are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
    Type: Grant
    Filed: July 27, 1998
    Date of Patent: September 26, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Keith C. Silverman, Russell B. Lingham, Sheo Bux Singh, Deborah L. Zink, Ana Teran
  • HIV integrase inhibitors
    Patent number: 6110716
    Abstract: Natural products such as certain chaetochromins are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
    Type: Grant
    Filed: February 4, 1998
    Date of Patent: August 29, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Russell B. Lingham, Ali Shafiee, Keith C. Silverman, Ana M. Teran, Sheo Bux Singh, Deborah L. Zink
  • Bis-aryl ethers, compositions containing such compounds and methods of treatment
    Patent number: 5994412
    Abstract: A compound represented by the formula I is disclosed: ##STR1## or a pharmaceutically acceptable salt or hydrate thereof. The compound has inhibitory activity against the oncoprotein Raf.Also included are pharmaceutical compositions, methods of treating cancer, cultures of the producing fungal microorganism and methods of fermentative production of the compound.
    Type: Grant
    Filed: July 2, 1998
    Date of Patent: November 30, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Seok H. Lee, Maria T. Diez, Fernando Pelaez, Marina Mojena Sanchez, M. Dolores Vilella Amils, Hans E. Huber, Denis R. Patrick, Otto D. Hensens, Rosalind G. Jenkins, Leeyuan Huang, Annie Z. Zhao, Deborah L. Zink, Anne Dombrowski, Gerald F. Bills
  • Microbial transformation products with antifungal properties
    Patent number: 5972994
    Abstract: Biotransformation products of a fermentation with Streptomyces sp., (Merck Culture Collection MA7165) ATCC No. 55946 are potent antifungal agents. These products may be useful in the treatment of diseases caused by fungal pathogens such as Candida sp. and Cryptococcus neoformans.
    Type: Grant
    Filed: March 24, 1998
    Date of Patent: October 26, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Ali Shafiee, Guy H. Harris, Deborah L. Zink, Janet M. Sigmund, Mark J. Rosenbach, Suzanne Miller Mandala
  • Ermophilane sesquiterpenoids as HIV intergrase inhibitors
    Patent number: 5858738
    Abstract: Natural products such as certain ermophilane sesquiterpenoids and derivatives thereof are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. The fungal culture MF6254, Xylaria sp. (ATCC 74397) is also described and disclosed.
    Type: Grant
    Filed: November 4, 1997
    Date of Patent: January 12, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Russell B. Lingham, Jon David Polishook, Ali Shafiee, Keith C. Silverman, Sheo Bux Singh, Deborah L. Zink
  • Antifungal agent from sporomiella minimoides
    Patent number: 5801172
    Abstract: There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
    Type: Grant
    Filed: July 11, 1997
    Date of Patent: September 1, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Wendy H. Clapp-Shapiro, Bruce W. Burgess, Robert A. Giacobbe, Guy H. Harris, Suzanne Mandala, Jon Polishook, Mark Rattray, Rosemary A. Thornton, Deborah L. Zink, Angeles Cabello, Maria Teresa Diez, Isabel Martin, Fernando Pelaez
  • Inhibitors of farnesyl-protein transferase
    Patent number: 5789438
    Abstract: The present invention is directed to steroidal or terpenoidal compounds which inhibit farnesyl-protein transferase (FPTase). The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: August 4, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Sheo B. Singh, Russell B. Lingham, Keith C. Silverman, Deborah L. Zink, Isabel Martin, Fernando Pelaez, Manuel Sanchez
  • Antifungal agent obtained from hormonema
    Patent number: 5756472
    Abstract: There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
    Type: Grant
    Filed: January 27, 1997
    Date of Patent: May 26, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Jerrold M. Liesch, Maria S. Meinz, Janet C. Onishi, Sandra A. Morris, Robert E. Schwartz, Gerald F. Bills, Robert A. Giacobbe, Wendy S. Horn, Deborah L. Zink, Angeles Cabello, Maria T. Diez, Isabella Martin, Fernando Pelaez, Francisca Vicente
  • Antifungal agent
    Patent number: 5712151
    Abstract: There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
    Type: Grant
    Filed: October 21, 1996
    Date of Patent: January 27, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Sandra A. Morris, Gerald F. Bills, James E. Curotto, Sarah J. Dreikorn, Angela Basilio, Maria Teresa Diez, Fernando Pelaez, Francisca Vicente, Bruce W. Burgess, Stanley L. Streicher, Deborah L. Zink, John R. Thompson
  • Antifungal agent produced by arthrinium arundinis ATCC 74359
    Patent number: 5712109
    Abstract: There is disclosed a compound having the formula ##STR1## which is produced by the fungus, Arthrinium arundinis ATCC 74359, and exhibits antifungal activity.
    Type: Grant
    Filed: January 27, 1997
    Date of Patent: January 27, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Jerrold M. Liesch, Maria S. Meinz, Janet C. Onishi, Robert E. Schwartz, Gerald F. Bills, Robert A. Giacobbe, Deborah L. Zink, Angeles Cabello, Maria T. Diez, Isabella Martin, Fernando Pelaez, Francisca Vicente
  • Antifungal agent
    Patent number: 5702929
    Abstract: There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
    Type: Grant
    Filed: October 21, 1996
    Date of Patent: December 30, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Sandra A. Morris, James E. Curotto, Gerald F. Bills, Sarah J. Dreikorn, Stanley L. Streicher, Deborah L. Zink, John R. Thompson, Angela Basilio, Fernando Pelaez, Maria Teresa Diez, Francisca Vicente
  • Inhibitors of farnesyl-protein transferase
    Patent number: 5703067
    Abstract: The present invention is directed to steroidal or terpenoidal compounds which inhibit farnesyl-protein transferase (FPTase). The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer.
    Type: Grant
    Filed: May 8, 1995
    Date of Patent: December 30, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Hiranthi Jayasuriya, Russell B. Lingham, Fernando Pelaez, Manuel Sanchez, Keith C. Silverman, Sheo Bux Singh, Deborah L. Zink
  • Antifungal agent
    Patent number: 5686637
    Abstract: There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
    Type: Grant
    Filed: January 10, 1995
    Date of Patent: November 11, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Gerald F. Bills, James E. Curotto, S. Dreikorn, Robert A. Giacobbe, Guy H. Harris, Suzanne Miller Mandala, Rosemary A. Thornton, Deborah L. Zink, Angeles Cabello Arroyo, Fernando Pelaez Perez, Teresa Diez Matas, Francisca Vicente Perez