Patents by Inventor Deborah Nickerson

Deborah Nickerson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thermostable ligase mediated DNA amplification system for the detection of genetic diseases
    Publication number: 20040048308
    Abstract: The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from Thermus aquaticus strain HB8, and the use of this ligase in assays for the detection of specific sequences of nucleotides in a variety of nucleic acid samples, and more particularly in those samples containing a DNA sequence characterized by a difference in the nucleic acid sequence from a standard sequence including single nucleic acid base pair changes, deletions, insertions or translocations.
    Type: Application
    Filed: September 12, 2003
    Publication date: March 11, 2004
    Inventors: Francis Barany, John Zebala, Deborah Nickerson, Robert J. Kaiser, Leroy Hood
  • Thermostable ligase mediated DNA amplification system for the detection of genetic diseases
    Patent number: 6054564
    Abstract: The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from Thermus aquaticus strain HB8, and the use of this ligase for the detection of specific sequences of nucleotides in a variety of nucleic acid samples, and more particularly in those samples containing a DNA sequence characterized by a difference in the nucleic acid sequence from a standard sequence including single nucleic acid base pair changes, deletions, insertions or translocations.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: April 25, 2000
    Assignees: Cornell Research Foundation, Inc., California Institute of Technology
    Inventors: Francis Barany, John Zebala, Deborah Nickerson, Robert J. Kaiser, Jr., Leroy Hood
  • Thermostable ligase mediated DNA amplification system for the detection of genetic diseases
    Patent number: 5830711
    Abstract: The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from Thermus aquaticus strain HB8, and the use of this ligase for the detection of specific sequences of nucleotides in a variety of nucleic acid samples, and more particularly in those samples containing a DNA sequence characterized by a difference in the nucleic acid sequence from a standard sequence including single nucleic acid base pair changes, deletions, insertions or translocations.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 3, 1998
    Assignees: Cornell Research Foundation, Inc., California Institute of Technology
    Inventors: Francis Barany, John Zebala, Deborah Nickerson, Robert J. Kaiser, Jr., Leroy Hood
  • Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
    Patent number: 5494810
    Abstract: The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from Thermus aquaticus strain HB8, and the use of this ligase in a ligase chain reaction (LCR) assay for the detection of specific sequences of nucleotides in a variety of nucleic acid samples, and more particularly in those samples containing a DNA sequence characterized by a difference in the nucleic acid sequence from a standard sequence including single nucleic acid base pair changes, deletions, insertions or translocations.
    Type: Grant
    Filed: November 22, 1994
    Date of Patent: February 27, 1996
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Francis Barany, John Zebala, Deborah Nickerson, Robert J. Kaiser, Jr., Leroy Hood