Patents by Inventor Deborah R. Moorad

Deborah R. Moorad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Previns as specific inhibitors and therapeutic agents for botulinum toxin B and tetanus neurotoxins
    Patent number: 7375079
    Abstract: The compounds of the invention are generally described by the formula: B1Z*2B3Z*4X*5Q6F7X8X9X10X11, ??(1) B1X2X3X4X5Q6F7X8X9X10X11, or ??(2) B1Z2B3X4Z5Q6F7Z8X9X10X11 ??(3) and the salts, esters, amides, and acyl forms thereof. Each position represented by a letter indicates a single amino acid residue: B is a basic of polar/large amino acid or a modified form thereof; X is a small or hydrophobic amino acid or a modified form thereof; X* is a small or polar/large amino acid or a modified form thereof; Z is a polar/large or hydrophobic amino acid or a modified form thereof; Z* is Proline or a polar/large of hydrophobic amino acid or a modified form thereof. As described below, one or more of the peptide linkages between the amino acid residues may be replaced by a peptide linkage mimic. These compounds may be used as molecular building blocks to create compounds that are optimized for inhibiting the protease activity of Botulinum b and tetanus toxins.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: May 20, 2008
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Richard K. Gordon, Deborah R. Moorad, Bhupendra P. Doctor, Gregory E. Garcia
  • Previns as specific inhibitors and therapeutic agents for botulinum toxin B and tetanus neurotoxins
    Patent number: 7235521
    Abstract: The compounds of the invention are generally described by the formula (1): B1Z*2B3Z*4X*5Q6F7X8X9X10X11, (2): B1X2X3X4X5Q6F7X8X9X10X11, or (3): B1X2B3X4Z5Q6F7Z8X9X10X11 and the salts, esters, amides, and acyl forms thereof. Each position represented by a letter indicates a single amino acid residue: B is a basic or polar/large amino acid or a modified form thereof; X is a small or hydrophobic amino acid or a modified form thereof; X* is a small or polar/large amino acid or a modified form thereof; Z is a polar/large or hydrophobic amino acid or a modified form thereof; Z* is Proline or a polar/large or hydrophobic amino acid or a modified form thereof. As described below, one or more of the peptide linkages between the amino acid residues may be replaced by a peptide linkage mimic. These compounds may be used as molecular building blocks to create compounds that are optimized for inhibiting the protease activity of Botulinum B and tetanus toxins.
    Type: Grant
    Filed: May 15, 2000
    Date of Patent: June 26, 2007
    Assignee: United States of America as represented by the Secretary of the Army
    Inventors: Richard K. Gordon, Deborah R. Moorad, Bhupendra P. Doctor, Gregory E. Garcia