Abstract: A system and method are disclosed for reconstructing contrast-enhanced CT images that are substantially free of beam-hardening artifacts. An imaging system includes a radiation source configured to project radiation toward an object to be scanned and an energy discriminating detector assembly having a plurality of detector elements and configured to detect radiation emitted by the radiation source and attenuated by the object to be scanned. The imaging system also includes computer programmed to count a number of photons detected by each detector element and associate an energy value to each counted photon and determine a material composition of a CT view from the number of photons counted and the energy value associated with each counted photon. The computer is also programmed to apply a weighting to the CT view based on the material composition of the CT view and reconstruct an image with differential weighting based on the weighting of the CT view.

Abstract: A CT scanner acquires CT images at different energy levels and registers those images to provide a composite image that is substantially free of beam hardening artifacts and conspicuously provides atomic information of that imaged.

Abstract: A CT scanner acquires CT images at different energy levels and registers those images to provide a composite image that is substantially free of beam hardening artifacts and conspicuously provides atomic information of that imaged.

Abstract: An imaging scanner includes a radiation source, a radiation detector, and a computer programmed to decompose CT data acquired by the radiation detector into a set of pixels, each pixel having at least a first basis material content and a second basis material content. The computer is further programmed to identify a first subset of the set of pixels as a possible embolism, based on the content of the first basis material and the content of the second basis material.

Abstract: The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites.

Abstract: The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites.

Abstract: The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites.

Abstract: A bowtie filter is constructed to have a fluidic envelope filled with attenuating fluid and a displacement insert that can present various x-ray attenuation profiles during a scan. The insert is designed to displace the attenuating fluid to achieve a denied attenuating or filtering profile. The insert can be rotated, twisted, moved, and otherwise contorted within the fluidic envelope as needed during the course of a scan. As the angle, position and shape of the zombie is changed, the x-ray profile of the filter changes. The insert may have a default shape when at rest, but can have its shape changed when external forces are placed thereon. As x-ray filtering needs change during the course of the scan, the insert can be compressed, stretched, and/or contorted to achieve additional filtering profiles.

Abstract: A method and system of CT colonography is presented that includes the acquisition of energy sensitive or energy-discriminating CT data from a colorectal region of a subject. CT data is acquired and decomposed into basis material density maps and used to differentiate and enhance contrast between tissues in the colorectal region. The invention is particularly applicable with the detection of colon polyps without cathartic preparation or insufflation of the colorectal region. The invention is further directed to the automatic detection of colon polyps.

Abstract: A method of enhancing image quality and providing tissue composition information by analysis of energy discrimination data, the method comprising determining a radiation dosage at one or more energy spectrum levels based on patient parameters and user selected parameters. Computer-readable medium and systems that afford functionality of the type defined by this method are also contemplated in conjunction with the present technique.

Abstract: A method of scanning a subject to be imaged is presented. The method includes acquiring projection data from a first region of a pixel, where the first region has a first area. Additionally, the method includes acquiring projection data from a second region of the pixel, where the second region has a second area. The method also includes combining projection data from the first and second regions to obtain composite projection data for the pixel. Computer-readable medium and systems that afford functionality of the type defined by this method are also contemplated in conjunction with the present technique.

Abstract: A method for reducing mis-registration during multiple energy scanning on computed tomographic (CT) imaging systems or multiple energy electron beam tomographic (EBT) systems includes scanning a portion of a patient including a cyclically moving body part using a multiple energy computed tomographic (CT) imaging system or multiple energy electron beam tomographic (EBT) system having at least two different energies, monitoring the cyclically moving body part, and gating the multiple energy CT imaging system or multiple energy EBT system in accordance with the monitored cyclically moving body part so that acquisitions are acquired at at least two different kVps. The data acquired at the different kVps are then utilized to generate material decomposition images of the cyclically moving body part.

Abstract: A computed tomography detector module is presented. The detector module includes a substrate having a topside and a bottom side. Additionally, the detector module includes a plurality of detector layers disposed on the top side of the substrate in a direction that is substantially orthogonal to the substrate, where each of the plurality of detector layers comprises a direct conversion material configured to absorb radiation, and where each of the plurality of detector layers comprises a first side and a second side. Further, the detector module includes a plurality of pixelated anode contacts is disposed on the first side of each of the plurality of detector layers. Also, the detector module includes a common cathode contact is disposed on the second side of each of the plurality of detector layers.

Abstract: A system and method for classifying whether an object within an enclosed article is a threat. The system includes an acquisition subsystem, a reconstruction subsystem, an energy discrimination subsystem, and a classification subsystem. The acquisition subsystem communicates projection data to the reconstruction subsystem.

Abstract: A method and apparatus for providing a configurable field of view in a non-invasive imaging system, such as a CT medical imaging system. A detector structure comprising two or more flat-panel X-ray detectors is provided such that the configurable field of view may encompass the full area of the two or more X-ray detectors or any suitable subset of the full area. The field of view may be configured based upon an acceptable field of view in conjunction with an acceptable scan speed.

Abstract: A method and system of CT colonography is presented that includes the acquisition of energy sensitive or energy-discriminating CT data from a colorectal region of a subject. CT data is acquired and decomposed into basis material density maps and used to differentiate and enhance contrast between tissues in the colorectal region. The invention is particularly applicable with the detection of colon polyps without cathartic preparation or insufflation of the colorectal region. The invention is further directed to the automatic detection of colon polyps.

Abstract: A system and method are disclosed for reconstructing contrast-enhanced CT images that are substantially free of beam-hardening artifacts. An imaging system includes a radiation source configured to project radiation toward an object to be scanned and an energy discriminating detector assembly having a plurality of detector elements and configured to detect radiation emitted by the radiation source and attenuated by the object to be scanned. The imaging system also includes computer programmed to count a number of photons detected by each detector element and associate an energy value to each counted photon and determine a material composition of a CT view from the number of photons counted and the energy value associated with each counted photon. The computer is also programmed to apply a weighting to the CT view based on the material composition of the CT view and reconstruct an image with differential weighting based on the weighting of the CT view.

Abstract: A technique is disclosed for detecting contraband by obtaining image data from a computed tomography machine and generating variance data and a variance map from the image data acquired. The method includes obtaining a mean density value and a variation value for each voxel of the image data, segmenting the voxels into discrete objects, and determining whether any of the discrete objects is contraband.

Abstract: A technique is disclosed for generating variance data and a variance map from measured projection data acquired from a tomography system. The method comprises accessing the measured projection data from the tomography system. The method further comprises generating the variance map from the measured projection data and displaying, analyzing or processing the variance map. The variance data is determined based upon a statistical model from measured image data, and may be used for image analysis, data acquisition, in computer aided diagnosis routines, and so forth.

Abstract: A system and method for ascertaining the identity of an object within an enclosed article. The system includes an acquisition subsystem with a computed tomography machine and an alternate modality subsystem. The alternate modality subsystem includes a detector mounted to a rotatable gantry. The detector may be a quadrupole resonance unit, a dual energy x-ray unit, or a backscatter x-ray unit. The acquisition subsystem analyzes an article and distinguishes regions of interest (may contain contraband) from regions of no interest (do not contain contraband). The article is then transported to the alternate modality subsystem at which the detector further analyzes just the regions of interest.