Patents by Inventor Debra Donaldson

Debra Donaldson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYTOKINE RECEPTOR CHAIN
    Publication number: 20100086516
    Abstract: Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed. Methods of medical treatment using such molecules and antagonists of the IL-13/IL-13R interaction are also provided.
    Type: Application
    Filed: March 20, 2009
    Publication date: April 8, 2010
    Applicants: GENETICS INSTITUTE, LLC, THE JOHNS HOPKINS UNIVERSITY
    Inventors: Mary Collins, Debra Donaldson, Lori Fitz, Tamlyn Neben, Matthew J. Whitters, Clive Wood, Marsha Wills-Karp
  • Methods of using antibodies to human IL-13bc for inhibiting IL-13 binding
    Patent number: 7674591
    Abstract: Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed.
    Type: Grant
    Filed: February 27, 2006
    Date of Patent: March 9, 2010
    Assignee: Genetics Institute, LLC
    Inventors: Mary Collins, Debra Donaldson, Lori Fitz, Tamlyn Neben, Matthew Whitters, Clive Wood
  • Method and compositions for treating asthma
    Patent number: 7553487
    Abstract: The present invention is directed to methods for treating asthma.
    Type: Grant
    Filed: November 15, 2004
    Date of Patent: June 30, 2009
    Assignees: Genetics Institute, LLC, The Johns Hopkins University
    Inventors: Mary Collins, Debra Donaldson, Lori Fitz, Tamlyn Neben, Matthew J. Whitters, Clive Wood, Marsha Wills-Karp
  • Cytokine receptor chain
    Patent number: 7507706
    Abstract: Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed. Methods of medical treatment using such molecules and antagonists of the IL-13/IL-13R interaction are also provided.
    Type: Grant
    Filed: December 13, 1999
    Date of Patent: March 24, 2009
    Assignee: Genetics Institute, LLC
    Inventors: Mary Collins, Debra Donaldson, Lori Fitz, Tamlyn Neben, Matthew J. Whitters, Clive Wood, Marsha Wills-Karp
  • Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains
    Patent number: 7282206
    Abstract: Methods are provided for treating or inhibiting the formation of tissue fibrosis using IL-13 antagonists, including without limitation soluble forms of the IL-13 receptor.
    Type: Grant
    Filed: September 25, 2003
    Date of Patent: October 16, 2007
    Assignees: Wyeth, The United States of America as represented by the Department of Health and Human Services
    Inventors: Thomas A. Wynn, Monica G. Chiaramonte, Mary Collins, Debra Donaldson, Lori Fitz, Tamlyn Neben, Matthew J. Whitters, Clive Wood
  • Cytokine receptor chain
    Publication number: 20060177902
    Abstract: Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed.
    Type: Application
    Filed: February 27, 2006
    Publication date: August 10, 2006
    Applicant: Genetics Institute, Inc.
    Inventors: Mary Collins, Debra Donaldson, Lori Fitz, Tamlyn Neben, Matthew Whitters, Clive Wood
  • Antibodies to human IL-13bc and methods of their use in inhibiting IL-13 binding
    Patent number: 7078494
    Abstract: Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed.
    Type: Grant
    Filed: November 16, 2000
    Date of Patent: July 18, 2006
    Assignee: Genetics Institute, LLC
    Inventors: Mary Collins, Debra Donaldson, Lori Fitz, Tamlyn Neben, Matthew Whitters, Clive Wood
  • IL-13 binding agents
    Publication number: 20060073148
    Abstract: Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
    Type: Application
    Filed: June 17, 2005
    Publication date: April 6, 2006
    Inventors: Lioudmila Tchistiakova, Marion Kasaian, Debra Donaldson, Xiang-Yang Tan, Davinder Gill, Macy Jin, Bruce Jacobson, Samuel Goldman, John Knopf, Angela Widom
  • Antibodies against human interleukin-13 and uses therefor
    Publication number: 20060063228
    Abstract: This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.
    Type: Application
    Filed: June 9, 2005
    Publication date: March 23, 2006
    Inventors: Marion Kasaian, Lioudmila Tchistiakova, Geertruida Veldman, Kimberly Marquette, Xiang-Yang Tan, Debra Donaldson, Laura Lin, Tania Shane, Amy Tam, Eric Feyfant, Nancy Wood, Lori Fitz, Angela Widom, Kevin Parris, Samuel Goldman, Jose Saldanha
  • Modulation of immunoglobulin production and atopic disorders
    Publication number: 20060024268
    Abstract: An IL-21 polypeptide or other IL-21 pathway agonist can be used to treat atopic disorders, e.g., asthma.
    Type: Application
    Filed: May 19, 2005
    Publication date: February 2, 2006
    Inventors: Marion Kasaian, Debra Donaldson, Mary Collins, Nancy Wood
  • Cytokine receptor chain
    Publication number: 20050277126
    Abstract: The present invention is directed to methods for treating asthma.
    Type: Application
    Filed: November 15, 2004
    Publication date: December 15, 2005
    Inventors: Mary Collins, Debra Donaldson, Lori Fitz, Tamlyn Neben, Matthew Whitters, Clive Wood, Marsha Wills-Karp
  • Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains
    Publication number: 20050096268
    Abstract: Methods are provided for treating or inhibiting the formation of tissue fibrosis using IL-13 antagonists, including without limitation soluble forms of the IL-13 receptor.
    Type: Application
    Filed: September 25, 2003
    Publication date: May 5, 2005
    Inventors: Thomas Wynn, Monica Chiaramonte, Mary Collins, Debra Donaldson, Lori Fitz, Tamlyn Neben, Matthew Whitters, Clive Wood
  • Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains
    Patent number: 6664227
    Abstract: Methods are provided for treating or inhibiting the formation of tissue fibrosis using IL-13 antagonists, including without limitation soluble forms of the IL-13 receptor.
    Type: Grant
    Filed: November 29, 1999
    Date of Patent: December 16, 2003
    Assignees: Genetics Institute, LLC, The United States of America as represented by the Department of Health and Human Services
    Inventors: Thomas A. Wynn, Monica G. Chiaramonte, Mary Collins, Debra Donaldson, Lori Fitz, Tamlyn Neben, Matthew J. Whitters, Clive Wood
  • IL-13 Receptor chain
    Patent number: 6268480
    Abstract: IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: July 31, 2001
    Assignee: Genetics Institute, Inc.
    Inventors: Mary Collins, Debra Donaldson, Lori Fitz, Tamlyn Neben, Matthew Whitters, Clive Wood
  • Methods of inhibiting binding and treating Ig-mediated responses with IL-13 receptor
    Patent number: 6248714
    Abstract: IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor methods of mediating-Ig-responses and methods for their identification are also disclosed.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: June 19, 2001
    Assignee: Genetics Institute, Inc.
    Inventors: Mary Collins, Debra Donaldson, Lori Fitz, Tamlyn Neben, Matthew Whitters, Clive Wood
  • Methods of identifying inhibitors of binding of IL-13 to the IL-13 receptor chain
    Patent number: 6214559
    Abstract: Methods of identifying inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: April 10, 2001
    Assignee: Genetics Institute, Inc.
    Inventors: Mary Collins, Debra Donaldson, Lori Fitz, Tamlyn Neben, Matthew Whitters, Clive Wood
  • IL-13 cytokine receptor chain
    Patent number: 5710023
    Abstract: Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: January 20, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Mary Collins, Debra Donaldson, Lori Fitz, Tamlyn Neben, Matthew Whitters, Clive Wood