Patents by Inventor Debra J. Wolgemuth

Debra J. Wolgemuth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SIDE POPULATION CELLS IN CARDIAC REPAIR
    Publication number: 20130011373
    Abstract: It has been discovered that side-population cells induce cardiac tissue repair of infarcted myocardium. Provided herein are methods directed to treatment of cardiac injury using side-population cells.
    Type: Application
    Filed: June 14, 2012
    Publication date: January 10, 2013
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Hina W. Chaudhry, Debra J. Wolgemuth
  • Side population cells in cardiac repair
    Patent number: 8221740
    Abstract: It has been discovered that side-population cells induce cardiac tissue repair of infarcted myocardium. Provided herein are methods directed to treatment of cardiac injury using side-population cells.
    Type: Grant
    Filed: September 26, 2006
    Date of Patent: July 17, 2012
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Hina W. Chaudhry, Debra J. Wolgemuth
  • Compositions and methods for treating and preventing heart tissue degeneration, and uses thereof
    Patent number: 8217157
    Abstract: The present invention provides methods for promoting generation of heart tissue, and for treating and preventing heart tissue degeneration. Additionally, the present invention provides a therapeutic composition comprising a cyclin-associated agent, and a kit comprising the composition. The present invention further provides a heart tissue cell, a sidepopulation progenitor cell, and a stem cell in which cyclin is augmented. Also provided are cell lines comprising these cells, screening methods using the cell lines, and drugs identified by these methods. The present invention further provides in vitro systems for use in screening candidate drugs for at least one cardiotoxic effect and/or for synergy with cyclin in the treatment and prevention of heart tissue degeneration. Finally, the present invention provides use of a cyclin-associated agent in the generation of heart tissue, and use of a cyclin associated agent in the treatment or prevention of heart tissue degeneration.
    Type: Grant
    Filed: May 18, 2004
    Date of Patent: July 10, 2012
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Hina W. Chaudhry, Debra J. Wolgemuth
  • Compositions and methods for treating and preventing heart tissue degeneration and uses thereof
    Patent number: 7645734
    Abstract: The present invention provides compositions useful for cardiac therapy comprising a cyclin-associated agent. The present invention also provides kits for use in delivering a cyclin-associated agent to cardiac cells in a subject, comprising the composition of the present invention and a catheter. The present invention additionally provides a methods for enhancing cardiac function; promoting regeneration of cardiac tissue; inducing endogenous myocardial regeneration; and preventing or treating heart failure in a subject in need thereof by augmenting cyclin in cells.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: January 12, 2010
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Hina W. Chaudhry, Debra J. Wolgemuth