Patents by Inventor Debra Jane Wallace

Debra Jane Wallace has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11274096
    Abstract: The present disclosure relates to novel processes for the preparation of compounds of Formula I. Some of these compounds are useful as simulators of soluble guanylate cyclase (sGC). Others are useful intermediates towards the preparation of said simulators. These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyrazoles of Formula I in high purity and yields. The present invention has the additional advantage of facile reaction conditions, amenable to scale up for large scale manufacturing. The disclosure also provides novel intermediates useful in the preparation of said compounds.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: March 15, 2022
    Assignee: Cyclerion Therapeutics, Inc.
    Inventors: Debra Jane Wallace, Fenger Zhou, Yuguang Wang, Takashi Nakai, Vishnu Vardhan Reddy Karnati, Wayne C. Schairer, William Kissel, Song Xue, Ahmad Hashash
  • Publication number: 20220024909
    Abstract: The present disclosure relates to novel processes for the preparation of compounds of Formula I. Some of these compounds are useful as stimulators of soluble guanylate cyclase (sGC). Others are useful intermediates towards the preparation of said stimulators. These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyrazoles of Formula I in high purity and yields. The present invention has the additional advantage of facile reaction conditions, amenable to scale up for large scale manufacturing. The disclosure also provides novel intermediates useful in the preparation of said compounds.
    Type: Application
    Filed: October 8, 2021
    Publication date: January 27, 2022
    Inventors: Debra Jane Wallace, Fenger Zhou, Yuguang Wang, Takashi Nakai, Vishnu Vardhan Reddy Karnati, Wayne C. Schairer, William Kissel, Song Xue, Ahmad Hashash
  • Publication number: 20210053962
    Abstract: The present disclosure relates to novel processes for the preparation of compounds of Formula I. Some of these compounds are useful as simulators of soluble guanylate cyclase (sGC). Others are useful intermediates towards the preparation of said simulators. These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyrazoles of Formula I in high purity and yields. The present invention has the additional advantage of facile reaction conditions, amenable to scale up for large scale manufacturing. The disclosure also provides novel intermediates useful in the preparation of said compounds.
    Type: Application
    Filed: January 10, 2019
    Publication date: February 25, 2021
    Inventors: Debra Jane Wallace, Fenger Zhou, Yuguang Wang, Takashi Nakai, Vishnu Vardhan Reddy Karnati, Wayne C. Schairer, William Kissel, Song Xue, Ahmad Hashash
  • Publication number: 20210017160
    Abstract: This invention relates to deuterated compounds of Formula I, and pharmaceutically acceptable salts thereof. or a pharmaceutically acceptable salt thereof, wherein each of Y1, Y2, Y3, Y4, Y5a, Y5b, Y6, Y7, Y8, Y9, Y10, Y11a and Y11b is independently selected from hydrogen and deuterium, as well as pharmaceutical compositions, methods and uses thereof.
    Type: Application
    Filed: July 14, 2020
    Publication date: January 21, 2021
    Inventors: Thomas Wai-Ho Lee, Song Xue, Vishnu Vardhan Reddy Karnati, Debra Jane Wallace
  • Publication number: 20210017161
    Abstract: This invention relates to deuterated compounds of Formula I, and pharmaceutically acceptable salts thereof. or a pharmaceutically acceptable salt thereof, wherein each of Y1, Y2, Y3, Y4, Y5a, Y5b, Y6, Y7, Y8, Y9, Y10, Y11a, Y11b, Y12a and Y12b is independently selected from hydrogen and deuterium, as well as pharmaceutical compositions, methods and uses thereof.
    Type: Application
    Filed: July 14, 2020
    Publication date: January 21, 2021
    Inventors: Thomas Wai-Ho Lee, Song Xue, Vishnu Vardhan Reddy Karnati, Debra Jane Wallace
  • Patent number: 6515126
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I) wherein Ts is a tosylate group and R is an alkyl group, an unsubstituted phenyl or substituted phenyl ring, or a benzyl or substituted benzyl group; which comprises: (i) cyclising a compound of formula (II) in the presence of a suitable catalyst; and (ii) purifying and collecting the resultant compound of formula (I).
    Type: Grant
    Filed: February 27, 2001
    Date of Patent: February 4, 2003
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Michael Stewart Ashwood, Ian Frank Cottrell, Cameron John Cowden, Debra Jane Wallace