Patents by Inventor Debra M. Mills

Debra M. Mills has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Broad spectrum inhibitors of filoviruses
    Patent number: 11459308
    Abstract: The present invention is related to the development of therapeutics and prophylactics for the treatment and/or prevention of filovirus infection in humans and other mammals. A new class of small molecules is disclosed that inhibits the interaction of naturally processed (i.e., proteolytically cleaved) filovirus glycoprotein (GPCL) with its host receptor Niemann-Pick C1 (NPC1) protein and thus block infection of host cells by filoviruses. Also disclosed are methods of using the small molecule inhibitors in the treatment/prevention of filovirus infection.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: October 4, 2022
    Assignees: Microbiotix, Inc., Albert Einstein College of Medicine, The Government of the United States as Represented by the Secretary of the Army
    Inventors: Terry L. Bowlin, Donald T. Moir, Kartik Chandran, John M. Dye, Jr., John D. Williams, Zachary D. Aron, Jay P. Barbor, Kelly N. Lively, Peter J. Nash, Debra M. Mills, Arnab Basu
  • BROAD SPECTRUM INHIBITORS OF FILOVIRUSES
    Publication number: 20190292165
    Abstract: The present invention is related to the development of therapeutics and prophylactics for the treatment and/or prevention of filovirus infection in humans and other mammals. A new class of small molecules is disclosed that inhibits the interaction of naturally processed (i.e., proteolytically cleaved) filovirus glycoprotein (GPCL) with its host receptor Niemann-Pick C1 (NPC1) protein and thus block infection of host cells by filoviruses. Also disclosed are methods of using the small molecule inhibitors in the treatment/prevention of filovirus infection.
    Type: Application
    Filed: December 5, 2017
    Publication date: September 26, 2019
    Applicants: Microbiotix, Inc., Albert Einstein College Of Medicine, Inc., The Govermnment Of The United States As Represented By The Secretary Of The Army
    Inventors: Terry L. Bowlin, Donald T. Moir, Kartik Chandran, John M. Dye, John D. Williams, Zachary D. Aron, Jay P. Barbor, Kelly N. Lively, Peter J. Nash, Debra M. Mills, Arnab Basu
  • Inhibitors of viral entry into mammalian cells
    Patent number: 9212134
    Abstract: The present invention is related to the development of compounds and methods for inhibiting viral infection in a mammal. A pseudotype virus was developed for use in a high throughput assay for identifying nonpeptidic small molecule inhibitors that prevent viral entry into a host cell.
    Type: Grant
    Filed: September 13, 2011
    Date of Patent: December 15, 2015
    Assignee: Microbiotix, Inc.
    Inventors: Arnab Basu, Debra M. Mills, John D. Williams, Bing Li, Norton P. Peet, Terry L. Bowlin
  • Inhibitors of filovirus entry into host cells
    Patent number: 9101635
    Abstract: Organic compounds showing the ability to inhibit viral glycoprotein (GP)-mediated entry of a filovirus into a host cell are disclosed. The disclosed filovirus entry inhibitor compounds are useful for treating, preventing, or reducing the spread of infections by filovirus including the type species Marburg virus (MARV) and Ebola virus (EBOV). Preferred inhibitors of the invention provide therapeutic agents for combating the Ivory Coast, Sudan, Zaire, Bundibugyo, and Reston Ebola virus strains.
    Type: Grant
    Filed: July 10, 2010
    Date of Patent: August 11, 2015
    Assignee: MICROBIOTIX, INC.
    Inventors: Arnab Basu, Debra M. Mills, Norton P. Peet, John D. Williams
  • INHIBITORS OF VIRAL ENTRY INTO MAMMALIAN CELLS
    Publication number: 20130331456
    Abstract: The present invention is related to the development of compounds and methods for inhibiting viral infection in a mammal. A pseudotype virus was developed for use in a high throughput assay for identifying nonpeptidic small molecule inhibitors that prevent viral entry into a host cell.
    Type: Application
    Filed: September 13, 2011
    Publication date: December 12, 2013
    Inventors: Arnab Basu, Debra M. Mills, John D. Williams, Bing Li, Norton P. Peet, Terry L. Bowlin
  • INHIBITORS OF FILOVIRUS ENTRY INTO HOST CELLS
    Publication number: 20120189614
    Abstract: Organic compounds showing the ability to inhibit viral glycoprotein (GP)-mediated entry of a filovirus into a host cell are disclosed. The disclosed filovirus entry inhibitor compounds are useful for treating, preventing, or reducing the spread of infections by filovirus including the type species Marburg virus (MARV) and Ebola virus (EBOV). Preferred inhibitors of the invention provide therapeutic agents for combating the Ivory Coast, Sudan, Zaire, Bundibugyo, and Reston Ebola virus strains.
    Type: Application
    Filed: July 10, 2010
    Publication date: July 26, 2012
    Applicant: Crobiotix, Inc.
    Inventors: Arnab Basu, Debra M. Mills, Norton P. Peet, John D. Williams