Patents by Inventor Debra Skelnik
Debra Skelnik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20210324025Abstract: Compositions of proteoglycans and core proteins thereof and related methods of treating subjects, e.g., patients, are described. The method may include applying a composition to an eye of a subject before, during, and/or after an intraocular medical procedure. The composition may comprise a proteoglycan or core protein thereof, such as decorin proteoglycan or decorin core protein, and a pharmaceutically-acceptable salt. The composition may be in the form of an aqueous solution, viscoelastic gel, or viscoelastic film, for example. Further methods are described that include treating donor corneal tissue with a composition comprising a proteoglycan or core protein thereof. The treated donor corneal tissue may be used as or in a corneal graft, such as during endothelial keratoplasty.Type: ApplicationFiled: April 30, 2020Publication date: October 21, 2021Applicant: D&D Biopharmaceuticals, Inc.Inventors: Bruce H. DeWOOLFSON, Dale P. DeVORE, Richard A. EIFERMAN, Debra SKELNIK
-
Publication number: 20210322521Abstract: Compositions of proteoglycans and core proteins thereof and related methods of treating subjects, e.g., patients, are described. The method may include applying a composition to an eye of a subject before, during, and/or after an intraocular medical procedure. The composition may comprise a proteoglycan or core protein thereof, such as decorin proteoglycan or decorin core protein, and a pharmaceutically-acceptable salt. The composition may be in the form of an aqueous solution, viscoelastic gel, or viscoelastic film, for example. Further methods are described that include treating donor corneal tissue with a composition comprising a proteoglycan or core protein thereof. The treated donor corneal tissue may be used as or in a corneal graft, such as during endothelial keratoplasty.Type: ApplicationFiled: April 20, 2020Publication date: October 21, 2021Applicant: D&D Biopharmaceuticals, Inc.Inventors: Bruce H. DeWOOLFSON, Dale P. DeVore, Richard A. Eiferman, Debra Skelnik
-
Patent number: 9612110Abstract: An observation device includes: a holding board that holds an observation container accommodating a cornea for transplantation to be observed; a specular reflection optical system including an illumination optical system and an imaging optical system, which include a light source and an imaging unit, for observing the cornea for transplantation; and an auxiliary light source that illuminates the cornea for transplantation from the back and has an auxiliary illumination optical axis inclined with respect to an observation base axis that divides in half an intersecting angle of the illumination optical axis of the illumination optical system and an imaging optical axis of the imaging optical system, wherein the auxiliary light source is installed in a freely pivoting manner about a predetermined rotation axis so that a relative inclination angle with respect to the observation base axis of the auxiliary illumination optical axis can be continuously changed.Type: GrantFiled: August 12, 2014Date of Patent: April 4, 2017Assignee: KONAN MEDICAL, INC.Inventors: Debra Skelnik, Yoichi Hamada
-
Patent number: 9167809Abstract: An apparatus for shipping, storing, and viewing a cornea comprising a container having a viewing window in a container base, an inner sidewall, and a corneal basket arranged within said container base. The corneal basket is in contact with said inner sidewall and adapted to support a corneoscleral disc by including more than one corneal support rod and more than one disc support surface and a lid that sealingly engages with the container.Type: GrantFiled: June 17, 2010Date of Patent: October 27, 2015Assignee: Numedis IncorporatedInventors: Debra Skelnik, Roger Wilson, John R. Wilson
-
Publication number: 20150042956Abstract: An observation device includes: a holding board that holds an observation container accommodating a cornea for transplantation to be observed; a specular reflection optical system including an illumination optical system and an imaging optical system, which include a light source and an imaging unit, for observing the cornea for transplantation; and an auxiliary light source that illuminates the cornea for transplantation from the back and has an auxiliary illumination optical axis inclined with respect to an observation base axis that divides in half an intersecting angle of the illumination optical axis of the illumination optical system and an imaging optical axis of the imaging optical system, wherein the auxiliary light source is installed in a freely pivoting manner about a predetermined rotation axis so that a relative inclination angle with respect to the observation base axis of the auxiliary illumination optical axis can be continuously changed.Type: ApplicationFiled: August 12, 2014Publication date: February 12, 2015Inventors: Debra Skelnik, Yoichi Hamada
-
Publication number: 20110014690Abstract: An apparatus for shipping, storing, and viewing a cornea. The device offers an improvement to cornea health relative to conventional cornea containers.Type: ApplicationFiled: June 17, 2010Publication date: January 20, 2011Applicant: WILSON WOLF MANUFACTURINGInventors: Debra Skelnik, Roger Wilson, John R. Wilson
-
Publication number: 20110008877Abstract: An apparatus for shipping, storing, and viewing a cornea. The device offers an improvement to cornea health relative to conventional cornea containers.Type: ApplicationFiled: June 17, 2010Publication date: January 13, 2011Applicant: WILSON WOLF MANUFACTURINGInventors: Debra Skelnik, Roger Wilson, Daniel P. Welch, John R. Wilson
-
Patent number: 5407669Abstract: A defined serumfree medical solution for applications in Ophthalmology, that contains one or more cell nutrient supplements which maintains and enhances the preservation of eye tissues, including human corneal tissues at low temperatures (2.degree. C. to 15.degree. C.). This solution is composed of a defined aqueous nutrient and electrolyte solution, supplemented with a glycosaminoglycan(s), a deturgescent agent(s), an energy source(s), a buffer system(s), an antioxidant(s), membrane stabilizing components, antibiotic(s), ATP precursors and nutrient cell supplements.Type: GrantFiled: March 4, 1992Date of Patent: April 18, 1995Inventors: Richard L. Lindstrom, Debra Skelnik
-
Patent number: 5366964Abstract: A viscoelastic solution including a buffered solution, 0.01-10% chondroitin sulfate, 0.01-10% hydroxypropyl methylcellulose, and 0.01-10% sodium hyaluronate, pH adjusted to 6.0-8.0 at a osmolarity between 200-400 mOsmol/L. The buffered solution can be HEPES buffered minimal essential medium (MEM), phosphate buffered saline (PBS), or buffered balanced salt solution. A cell growth factor or cell growth supplement can also be included in the solution.Type: GrantFiled: November 13, 1989Date of Patent: November 22, 1994Inventors: Richard L. Lindstrom, Debra Skelnik
-
Patent number: 5204325Abstract: Viscoelastic solution including a buffered solution, 0.01-8% chondroitin sulfate, 0.1-8% hydroxypropyl methylcellulose, pH adjusted to 6.0-8.0 at a osmolality between 200-400 mOsmol/L. The buffered solution can be HEPES buffered minimum essential media (MEM), phosphate buffer saline (PBS), buffered balanced salt solution, or TC199. A cell growth factor or cell growth supplement is included in the solution.Type: GrantFiled: May 3, 1991Date of Patent: April 20, 1993Inventors: Richard L. Lindstrom, Debra Skelnik
-
Patent number: 5104787Abstract: A defined serumfree medical solution for applications in Ophthalmology, that contains one or more cell nutrient supplements which maintains and enhances the preservation of eye tissues, including human corneal tissues at low temperatures (2.degree. C. to 15.degree. C.). This solution is composed of a defined aqueous nutrient and electrolyte solution, supplemented with a glycosaminoglycan(s), a deturgescent agent(s), an energy source(s), a buffer system(s), an antioxidant(s), membrane stabilizing components, antibiotic(s), ATP precursors and nutrient cell supplements.Type: GrantFiled: March 5, 1990Date of Patent: April 14, 1992Inventors: Richard L. Lindstrom, Debra Skelnik
-
Patent number: 5013714Abstract: Viscoelastic solution including a buffered solution, 0.01-8% chondroitin sulfate, 0.1-8% hydroxypropyl methylcellulose, pH adjusted to 6.0-8.0 at a osmolality between 200-400 mOsmol/L. The buffered solution can be HEPES buffered minimum essential media (MEM), phosphate buffer saline (PBS), buffered balanced salt solution, or TC199. A cell growth factor or cell growth supplement is included in the solution.Type: GrantFiled: December 15, 1988Date of Patent: May 7, 1991Inventors: Richard L. Lindstrom, Debra Skelnik
-
Patent number: 4725586Abstract: A surgical or irrigation solution which provides the anterior and posterior chamber of the eye with protection during surgical procedures that require irrigation. This irrigation solution is composed of a HEPES buffered Eagle's Minimum Essential Media (MEM) with Earle's Salts, without phenol red, supplemented with mixed isomers of 99% pure, chondroitin sulfate, MEM non-essential amino acids, 2-mercaptoethanol, and sodium pyruvate. Other solutions include a balanced salt solution, chondroitin sulfate, buffers and 2-mercaptoethanol. The solution can also be used in other surgical or medical applications.Type: GrantFiled: March 4, 1986Date of Patent: February 16, 1988Inventors: Richard L. Lindstrom, Debra Skelnik
-
Patent number: 4695536Abstract: A universal tissue preservation system including a storage container and a preservation media for corneal and other tissue storage. The universal corneal preservation system provides for closed system storage (media not changed) at 4.degree. centigrade under refrigeration for 1-14 days or 34.degree. centigrade storage in an incubator for at least 35 days (five weeks). The storage system provides for a quarantine technique insuring sterility, and a special media for maintaining cell viability and corneal deturgescence, (normal thickness). The corneal storage container provides for endothelial cell photography and media sampling. The preservation media can also be utilized in an open batch technique (media changed at regular intervals) for storage of corneas over one year. In addition, the preservation media can be used as an intraocular irrigation fluid during surgery.Type: GrantFiled: January 10, 1984Date of Patent: September 22, 1987Inventors: Richard L. Lindstrom, Donald J. Doughman, Debra Skelnik