Patents by Inventor Debra Tonetti

Debra Tonetti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzothiophene-based selective estrogen receptor downregulators
    Patent number: 11447461
    Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.
    Type: Grant
    Filed: October 19, 2020
    Date of Patent: September 20, 2022
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Debra A. Tonetti
  • BENZOTHIOPHENE-BASED SELECTIVE ESTROGEN RECEPTOR DOWNREGULATOR COMPOUNDS
    Publication number: 20220194917
    Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.
    Type: Application
    Filed: July 26, 2021
    Publication date: June 23, 2022
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Debra A. Tonetti
  • Combination therapy for treatment of cancer
    Patent number: 11364222
    Abstract: Compositions, combinations and methods comprising a CDK4/6 inhibitor of Formula D with a selective estrogen receptor downregulator of Formula A, B or C that are advantageous for the treatment of abnormal cellular proliferation, including a cancer or a tumor.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: June 21, 2022
    Assignee: G1 Therapeutics, Inc.
    Inventors: Jay C. Strum, Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Debra A. Tonetti
  • Benzothiophene-based selective estrogen receptor downregulator compounds
    Patent number: 11072595
    Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: July 27, 2021
    Assignee: The Board of Trustees of lhe University of Illinois
    Inventors: Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Debra A. Tonetti
  • BENZOTHIOPHENE-BASED SELECTIVE ESTROGEN RECEPTOR DOWNREGULATORS
    Publication number: 20210047286
    Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.
    Type: Application
    Filed: October 19, 2020
    Publication date: February 18, 2021
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Debra A. Tonetti
  • Compositions and methods for treating estrogen-related medical disorders
    Patent number: 10888545
    Abstract: Disclosed herein are methods for treatment of estrogen-related medical disorders. The methods of treatment may comprise administering to a subject in need of such treatment a composition comprising a therapeutically effective amount of at least one compound of formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: January 12, 2021
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Gregory R. Thatcher, Debra Tonetti, Mary Ellen Molloy, Bradley Michalsen, Zihui Qin, Rui Xiong
  • RADIOTRACERS FOR IMAGING ER-POSITIVE BREAST CANCER
    Publication number: 20200360543
    Abstract: Disclosed herein are 18F-labeled compounds and compositions thereof. Also disclosed are methods of imaging estrogen receptor expressing tissues, or methods of identifying cancer lesions using these compounds.
    Type: Application
    Filed: June 29, 2020
    Publication date: November 19, 2020
    Inventors: Stephen DiMagno, Gregory R. Thatcher, Debra Tonetti, Rui Xiong, Bao Hu
  • Benzothiophene-based selective estrogen receptor downregulators
    Patent number: 10807964
    Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: October 20, 2020
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Debra A. Tonetti
  • Benzothiophene-based selective mixed estrogen receptor downregulators
    Patent number: 10703747
    Abstract: This invention is benzothiophene-based selective mixed estrogen receptor downregulators and their compositions and uses to treat estrogen-related disorders.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: July 7, 2020
    Assignee: The Board of Directors of the University of Illinois
    Inventors: Gregory R. Thatcher, Rui Xiong, Yunlong Lu, Jiong Zhao, Debra A. Tonetti
  • BENZOTHIOPHENE-BASED SELECTIVE ESTROGEN RECEPTOR DOWNREGULATOR COMPOUNDS
    Publication number: 20200123126
    Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.
    Type: Application
    Filed: May 28, 2019
    Publication date: April 23, 2020
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Debra A. Tonetti
  • COMBINATION THERAPY FOR TREATMENT OF CANCER
    Publication number: 20190321332
    Abstract: Compositions, combinations and methods comprising a CDK4/6 inhibitor of Formula D with a selective estrogen receptor downregulator of Formula A, B or C that are advantageous for the treatment of abnormal cellular proliferation, including a cancer or a tumor.
    Type: Application
    Filed: July 2, 2019
    Publication date: October 24, 2019
    Applicants: G1 Therapeutics, Inc., The Board of Trustees of the University of Illinois
    Inventors: JAY C. STRUM, Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Debra A. Tonetti
  • BENZOTHIOPHENE-BASED SELECTIVE MIXED ESTROGEN RECEPTOR DOWNREGULATORS
    Publication number: 20190248780
    Abstract: This invention is benzothiophene-based selective mixed estrogen receptor downregulators and their compositions and uses to treat estrogen-related disorders.
    Type: Application
    Filed: April 24, 2019
    Publication date: August 15, 2019
    Applicant: The Board of Trustees of the University of Illnois
    Inventors: Gregory R. Thatcher, Rui Xiong, Yunlong Lu, Jiong Zhao, Debra A. Tonetti
  • Benzothiophene-based selective estrogen receptor downregulators
    Patent number: 10377735
    Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: August 13, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Debra A. Tonetti
  • RADIOTRACERS FOR IMAGING ER-POSITIVE BREAST CANCER
    Publication number: 20190224346
    Abstract: Disclosed herein are 18F-labeled compounds and compositions thereof. Also disclosed are methods of imaging estrogen receptor expressing tissues, or methods of identifying cancer lesions using these compounds.
    Type: Application
    Filed: January 22, 2019
    Publication date: July 25, 2019
    Inventors: Stephen DiMagno, Gregory R. Thatcher, Debra Tonetti, Rui Xiong, Bao Hu
  • BENZOTHIOPHENE-BASED SELECTIVE ESTROGEN RECEPTOR DOWNREGULATORS
    Publication number: 20190055209
    Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.
    Type: Application
    Filed: October 24, 2018
    Publication date: February 21, 2019
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Debra A. Tonetti
  • Benzothiophene-based selective estrogen receptor downregulators
    Patent number: 10118910
    Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: November 6, 2018
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Debra A. Tonetti
  • COMPOSITIONS AND METHODS FOR TREATING ESTROGEN-RELATED MEDICAL DISORDERS
    Publication number: 20180214414
    Abstract: Disclosed herein are methods for treatment of estrogen-related medical disorders. The methods of treatment may comprise administering to a subject in need of such treatment a composition comprising a therapeutically effective amount of at least one compound of formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: January 31, 2018
    Publication date: August 2, 2018
    Inventors: Gregory R. Thatcher, Debra Tonetti, Mary Ellen Molloy, Bradley Michalsen, Zihui Qin
  • Compositions and methods for treating estrogen-related medical disorders
    Patent number: 9895348
    Abstract: Disclosed herein are methods for treatment of estrogen-related medical disorders. The methods of treatment may comprise administering to a subject in need of such treatment a composition comprising a therapeutically effective amount of at least one compound of formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 13, 2016
    Date of Patent: February 20, 2018
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Gregory R. Thatcher, Debra Tonetti, Mary Ellen Molloy, Bradley Michalsen, Zihui Qin
  • BENZOTHIOPHENE-BASED SELECTIVE ESTROGEN RECEPTOR DOWNREGULATORS
    Publication number: 20170166550
    Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.
    Type: Application
    Filed: December 9, 2016
    Publication date: June 15, 2017
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Debra A. Tonetti
  • BENZOTHIOPHENE-BASED SELECTIVE ESTROGEN RECEPTOR DOWNREGULATOR COMPOUNDS
    Publication number: 20170166551
    Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.
    Type: Application
    Filed: December 9, 2016
    Publication date: June 15, 2017
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Debra A. Tonetti