Patents by Inventor Debra Wolgemuth

Debra Wolgemuth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for treating and preventing heart tissue degeneration and uses thereof
    Patent number: 9132167
    Abstract: The present invention provides compositions useful for cardiac therapy comprising a cyclin-associated agent. The present invention also provides kits for use in delivering a cyclin-associated agent to cardiac cells in a subject, comprising the composition of the present invention and a catheter. The present invention additionally provides a methods for enhancing cardiac function; promoting regeneration of cardiac tissue; inducing endogenous myocardial regeneration; and preventing or treating heart failure in a subject in need thereof by augmenting cyclin in cells.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: September 15, 2015
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Hina Chaudhry, Debra Wolgemuth
  • COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING HEART TISSUE DEGENERATION AND USES THEREOF
    Publication number: 20110002894
    Abstract: The present invention provides compositions useful for cardiac therapy comprising a cyclin-associated agent. The present invention also provides kits for use in delivering a cyclin-associated agent to cardiac cells in a subject, comprising the composition of the present invention and a catheter. The present invention additionally provides a methods for enhancing cardiac function; promoting regeneration of cardiac tissue; inducing endogenous myocardial regeneration; and preventing or treating heart failure in a subject in need thereof by augmenting cyclin in cells.
    Type: Application
    Filed: December 18, 2009
    Publication date: January 6, 2011
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Hina Chaudhry, Debra Wolgemuth
  • Side Population Cells in Cardiac Repair
    Publication number: 20070178075
    Abstract: It has been discovered that side-population cells induce cardiac tissue repair of infarcted myocardium. Provided herein are methods directed to treatment of cardiac injury using side-population cells.
    Type: Application
    Filed: September 26, 2006
    Publication date: August 2, 2007
    Applicant: The Trustees of Columbia University In the City of New York
    Inventors: Hina Chaudhry, Debra Wolgemuth
  • Compositions and methods for treating and preventing heart tissue degeneration, and uses thereof
    Publication number: 20070014766
    Abstract: The present invention provides methods for promoting generation of heart tissue, and for treating and preventing heurt tissue degeneration. Additionally, the present invention provides a therapeutic composition comprising a cyclin-associated agent, and a kit comprising the composition. The present invention further provides a heart tissue tell, a sidepopulation progenitor tell, and a stem tell in which cyclin is augmented. Also provided are tell lins comprising these tells, screening methods using the tell lins, and drugs identified by these methods. The present invention further provides in vitro systems for use in screening candidate drugs for at least one cardiotoxic effect and/or for synergy with cyclin in the treatment and prevention of heart tissue degeneration. Finally, the present invention provides use of a cyclin-associated agent in the generation of heart tissue, and use of a cyclin associated agent in the treatment or prevention of heart tissue degeneration.
    Type: Application
    Filed: May 18, 2004
    Publication date: January 18, 2007
    Inventors: Hina Chaudhry, Debra Wolgemuth
  • Compositions and methods for treating and preventing heart tissue degeneration and uses thereof
    Publication number: 20060160733
    Abstract: The present invention provides compositions useful for cardiac therapy comprising a cyclin-associated agent. The present invention also provides kits for use in delivering a cyclin-associated agent to cardiac cells in a subject, comprising the composition of the present invention and a catheter. The present invention additionally provides a methods for enhancing cardiac function; promoting regeneration of cardiac tissue; inducing endogenous myocardial regeneration; and preventing or treating heart failure in a subject in need thereof by augmenting cyclin in cells.
    Type: Application
    Filed: November 4, 2005
    Publication date: July 20, 2006
    Inventors: Hina Chaudhry, Debra Wolgemuth