Patents by Inventor Debrabata RayChaudhuri

Debrabata RayChaudhuri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUND COMBINATIONS FOR INHIBITING CELL DIVISION AND METHODS FOR THEIR IDENTIFICATION AND USE
    Publication number: 20100311770
    Abstract: The present invention provides in vitro assays, e.g., FtsZ GTPase assays, and/or in vivo assays and methods of use thereof to identify particular compounds and combinations of compounds that affect microbial cell division. The invention further provides such compounds and compound combinations, including combinations that result in inhibition of cell survival or growth when present together at concentrations below their individual MICs. Certain of the compound combinations display synergism. Certain of the combinations include a compound that inhibits FtsZ GTPase activity and a compound that inhibits cell growth by a mechanism other than inhibition of FtsZ GTPase activity. The present invention further provides pharmaceutical compositions that have anti-microbial activity and methods of treating microbial infections.
    Type: Application
    Filed: June 14, 2006
    Publication date: December 9, 2010
    Applicants: President and Fellows of Harvard College, Trustees of Tufts College
    Inventors: Marc Kirschner, Debrabata RayChaudhuri
  • Compound combinations for inhibiting cell division and methods for their identification and use
    Patent number: 7575889
    Abstract: The present invention provides in vitro assays, e.g., FtsZ GTPase assays, and/or in vivo assays and methods of use thereof to identify particular compounds and combinations of compounds that affect microbial cell division. The invention further provides such compounds and compound combinations, including combinations that result in inhibition of cell survival or growth when present together at concentrations below their individual MICs. Certain of the compound combinations display synergism. Certain of the combinations include a compound that inhibits FtsZ GTPase activity and a compound that inhibits cell growth by a mechanism other than inhibition of FtsZ GTPase activity. The present invention further provides pharmaceutical compositions that have anti-microbial activity and methods of treating microbial infections.
    Type: Grant
    Filed: March 14, 2006
    Date of Patent: August 18, 2009
    Assignees: President and Fellows of Harvard College, Trustees of Tufts College
    Inventors: Debrabata RayChaudhuri, Marc Kirschner
  • Compound combinations for inhibiting cell division and methods for their identification and use
    Publication number: 20060252114
    Abstract: The present invention provides in vitro assays, e.g., FtsZ GTPase assays, and/or in vivo assays and methods of use thereof to identify particular compounds and combinations of compounds that affect microbial cell division. The invention further provides such compounds and compound combinations, including combinations that result in inhibition of cell survival or growth when present together at concentrations below their individual MICs. Certain of the compound combinations display synergism. Certain of the combinations include a compound that inhibits FtsZ GTPase activity and a compound that inhibits cell growth by a mechanism other than inhibition of FtsZ GTPase activity. The present invention further provides pharmaceutical compositions that have anti-microbial activity and methods of treating microbial infections.
    Type: Application
    Filed: March 14, 2006
    Publication date: November 9, 2006
    Inventors: Debrabata RayChaudhuri, Marc Kirschner