Patents by Inventor Debyra J. Groskreutz

Debyra J. Groskreutz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prohormone convertase transformed cells and polypeptide synthesis
    Publication number: 20030031654
    Abstract: Described is the production of mammalian cells expressing prohormone convertase which facilitates the processing of prohormone precursors to active hormones. Also described are variant prohormone convertases, and prohormones. The transformed cells of the present invention may be used in the synthesis of properly processed polypeptide hormones, and in cell culture to reduce dependence upon added hormones and required serum polypeptide factors.
    Type: Application
    Filed: November 28, 2001
    Publication date: February 13, 2003
    Applicant: Genentech, Inc.
    Inventors: Cornelia M. Gorman, Debyra J. Groskreutz
  • Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
    Patent number: 6348327
    Abstract: Provided are animal host cells not naturally capable of forming secretory granules and that produce active, mature insulin by expression of a variant proinsulin containing a non-naturally occurring cleavage site and enzymatic cleavage of the non-naturally occurring cleavage site in the host cells. Further provided are methods of culturing such cells.
    Type: Grant
    Filed: March 1, 1993
    Date of Patent: February 19, 2002
    Assignee: Genentech, Inc.
    Inventors: Cornelia M. Gorman, Debyra J. Groskreutz