Abstract: The invention provides a method of targeting a drug to areas of hypoxic and/or ischemic tissue within the body in which the desired drug species is linked to a non-cytotoxic bioreductive carrier. Also provided by the invention are novel bioreductive conjugates comprising a non-cytotoxic bioreductive moiety with linked-thereto at least one therapeutic agent. The compounds of the invention are particularly suitable for the treatment of rheumatoid arthritis and other arthritic conditions, diabetes, atherosclerosis, stroke, sepsis, Alzheimer's disease and other neurological disorders, cancer, kidney disease, digestive diseases, liver disease, chronic periodontitis or ischemia following tissue transplantation.

Abstract: Disclosed herein are antimicrobial compositions comprising an effective concentration of a metal salt combined with a plant extract. In some embodiments the composition comprises a copper salt and/or an iron salt and/or a nickel salt and/or a cobalt salt; and an extract of a plant selected from a group consisting of Punka granatum, Viburnum plicatum, Camellia sinensis, and Acer spp. The invention extends to uses of such compositions as medicaments, and to methods of treating microbial infections. The invention extends to methods for preventing microbial infections by coating objects and surfaces with the compositions.

Abstract: Compounds for use in the treatment of heart disease include a superoxide scavenger and an organic nitrate or nitrite moiety. The compounds can be represented by the formula (A)n(B)m, in which A is a superoxide scavenger, B is an organic nitrate or organic nitrite moiety, and n and m are values between 1 and 8. These compounds do not suffer from the problem of patient tolerance that is associated with the use of conventional agents such as organic nitrates.