Abstract: The present invention generally relates to various methods for treating the laminitis syndrome in animals. These benefits are obtained by administering to the animals a composition containing an &agr;-adrenergic antagonist that does not substantially cross the blood brain barrier. In one embodiment, the &agr;-adrenergic antagonist is domperidone. The domperidone can be administered to the animal either orally, subcutaneously, or intramuscularly and can be used to treat animals suffering from symptoms of laminitis.

Abstract: The present invention generally relates to various methods for treating the laminitis syndrome in animals. These benefits are obtained by administering to the animals a composition containing an &agr;-adrenergic antagonist that does not substantially cross the blood brain barrier. In one embodiment, the &agr;-adrenergic antagonist is domperidone.

Abstract: The present invention generally relates to various methods for promoting ovulation, parturition and lactation in female mammals. These benefits are obtained by administering to the mammals a composition containing a D2 receptor antagonist that does not substantially cross the blood brain barrier. In one embodiment, the D2 receptor antagonist is domperidone. The domperidone can be administered to the mammal either orally or subcutaneously and can be used to treat, for instance, anestrous mammals, mammals that have problems bearing offspring and mammals suffering from agalactia. Unexpectedly, it has also been discovered that the D2 receptor antagonist may also stimulate feed intake, causing the mammal to eat more and gain weight faster.

Abstract: The present invention generally relates to various methods for promoting ovulation, parturition and lactation in female mammals. These benefits are obtained by administering to the mammals a composition containing a D2 receptor antagonist that does not substantially cross the blood brain barrier. In one embodiment, the D2 receptor antagonist is domperidone. The domperidone can be administered to the mammal either orally or subcutaneously and can be used to treat, for instance, anestrous mammals, mammals that have problems bearing offspring and mammals suffering from agalactia. Unexpectedly, it has also been discovered that the D2 receptor antagonist may also stimulate feed intake, causing the mammal to eat more and gain weight faster.

Abstract: The present invention generally relates to various methods for promoting ovulation, parturition and lactation in female mammals. These benefits are obtained by administering to the mammals a composition containing a D2 receptor antagonist that does not substantially cross the blood brain barrier. In one embodiment, the D2 receptor antagonist is domperidone. The domperidone can be administered to the mammal either orally or subcutaneously and can be used to treat, for instance, anestrous mammals, mammals that have problems bearing offspring and mammals suffering from agalactia. Unexpectedly, it has also been discovered that the D2 receptor antagonist may also stimulate feed intake, causing the mammal to eat more and gain weight faster.

Abstract: A novel method for using domperidone, a dopamine receptor antagonist, for treating fescue toxicosis in animals is provided. Fescue toxicosis is caused by animals grazing on endophyte-infected fescue grass. Treatment of the animal with various dosages of domperidone results in effective management of the toxin. The domperidone treatments do not cause any substantial adverse behavioral or neurological side effects in the animal. Domperidone is a more effective treatment for fescue toxicosis than previously-known agents such a metoclopramide and sulpiride.

Abstract: A method of treating organic farm materials such as hays, grains, and silages confines same to a predetermined enclosure. A solid chemical mixture is introduced into the enclosure. The solid chemical mixture is a urea reactor product including ammonium carbamate, ammonia, urea, and water. Heat is applied to the mixture to thereby release sufficient gaseous ammonia to the organic farm material to prevent spoilage, reduce toxin levels, and improve fermentation of the organic farm material. The solid chemical mixture disposed amidst the organic farm material can be provided in a corrosion resistant drum having holes through the top thereof and having an electric resistance heater disposed in the bottom thereof or underneath same. A thermostatic control can control the temperature generated by the heater.