Abstract: The present invention generally relates to compositions and methods for treatment and prevention of vaginal infections. More particularly, the present invention relates to compositions including creatinine, such as protonated creatinine or creatinine salts, and optionally one or more weak acids, such as boric acid. The disclosed compositions may be used to treat and/or prevent a vaginal infection, such as bacterial vaginosis, to prevent recurrence of a vaginal infection, to treat and/or prevent a sexually transmitted disease (STD) or sexually transmitted infection (STI), and reduce the incidence and/or risk of a subject transmitting a STI or STD.

Abstract: Compositions, such as aqueous solutions and non-aqueous solutions and slurries, of a weak acid are provided. The disclosed compositions may be used to treat, prevent, and/or reduce one or more symptoms associated with numerous vaginal conditions or disturbances, such as odor and itch.

Abstract: A parenteral delivery device and method of delivering a multi-system treatment to a centralized location where the delivery device includes at least an inner compartment encapsulating a first system and an outer compartment encapsulating a second system and the first and second systems have different mechanisms of action for use in the treatment of vaginal infection.