Abstract: Provided herein are novel fused pyrimidinone derivatives of Formula I and synthetic intermediates that are useful in preparing the compounds of formula (I). Further provided herein is a method for preparation of a compound of formula (I) or intermediates, a pharmaceutical composition comprising a compound of formula (I), and use of a compound of formula (I).

Abstract: A method and system for generating a topic page for a search query on a search webpage includes receiving a query at the search webpage on a client. The query is transmitted from the search webpage on the client to a search engine on a server. A topic page generator available to the search engine analyzes the query to identify a plurality of dimensions. One or more content modules that match one or more of the dimensions are selected from a plurality of sources based on a weight associated with each of the content modules. The weight defines the ranking of a content module. The content modules for the plurality of dimensions are glued together and presented on the topic page in the order of the corresponding weight of the content modules. The order of presentation identifies the relevancy of the content modules to the query. The presented topic page provides the most relevant content modules for the query, and for a user located in a specific geo location.

Abstract: A method and apparatus for optimizing content on a topic page includes receiving a query for a topic at a topic page on a client and transmitting the query from the topic page on the client to a web application on a server. The web application includes algorithm to analyze the query to identify a plurality of content modules that match the query. The content modules are identified from anyone of a branded source or an un-branded source. One or more module performance indicators are computed for each of the identified content modules. An aggregate module performance indicator for each of the plurality of content modules is generated from the one or more computed module performance indicators. One or more content modules from the identified plurality of content modules are automatically selected for rendering on the topic page based on the aggregate module performance indicator associated with each of the identified content modules.

Abstract: Methods for guiding user moderation at a topic page by confidence levels includes presenting a topic page in response to a query. The topic page includes a plurality of modules with content that match the query. The topic page is associated with a confidence level and with one or more page attributes that define the characteristics of the topic page and the modules included therein. One or more modifications to the topic page are received as part of customization of the topic page. The modifications include a plurality of page attributes that define the modification and a plurality of user attributes of a user performing the modification. The modifications are evaluated based on the page attributes and user attributes including confidence levels associated with the topic page and the user. The modifications are implemented based on the evaluation. The implemented modifications enhance the quality and confidence level of the topic page.

Abstract: Methods and systems for reconstructing a full query based on a partial query are disclosed. Existing interfaces for search engines may be rigid and require users to submit full queries to perform searched. The methods and systems described herein may solve these problems by allowing a flexible way for users to submit a partial query and reconstruct a full query based on the partial query. A search may then be performed using the reconstructed query.

Abstract: Methods for optimizing webpage content by micro-bucket testing user customization to the webpage include presenting a plurality of modules at a webpage based on a request from a user. The modules define an intent of the webpage. A change defining customization to one or more modules within the webpage is detected. A test case representing the change is automatically generated. The generated test case is a modified webpage having the customization. The webpage is presented to a first segment of users as a control page and the modified webpage is presented to a second segment of users in response to a request for the webpage. User interaction by the first and segment of users is monitored at the webpage and the modified webpage to determine website metrics of the corresponding webpages. The website metrics is used in defining a new control page of the webpage from the modified webpage or retaining the webpage as the control page.

Abstract: Methods and systems for reconstructing a full query based on a partial query are disclosed. Existing interfaces for search engines may be rigid and require users to submit full queries to perform searched. The methods and systems described herein may solve these problems by allowing a flexible way for users to submit a partial query and reconstruct a full query based on the partial query. A search may then be performed using the reconstructed query.

Abstract: Methods and systems for reconstructing a full query based on a partial query are disclosed. Existing interfaces for search engines may be rigid and require users to submit full queries to perform searched. The methods and systems described herein may solve these problems by allowing a flexible way for users to submit a partial query and reconstruct a full query based on the partial query. A search may then be performed using the reconstructed query.

Abstract: A method and apparatus for optimizing content on a topic page includes receiving a query for a topic at a topic page on a client and transmitting the query from the topic page on the client to a web application on a server. The web application includes algorithm to analyze the query to identify a plurality of content modules that match the query. The content modules are identified from anyone of a branded source or an un-branded source. One or more module performance indicators are computed for each of the identified content modules. An aggregate module performance indicator for each of the plurality of content modules is generated from the one or more computed module performance indicators. One or more content modules from the identified plurality of content modules are automatically selected for rendering on the topic page based on the aggregate module performance indicator associated with each of the identified content modules.

Abstract: The present invention relates to a combination, such as a combined preparation or pharmaceutical composition comprising: (a) compound of formula (I), and/or (II) or a pharmaceutically acceptable salt thereof; (b) at least one therapeutic agent selected from the group consisting of: an antihypertensive agent; an antidiabetics agent; a hypolipidemic agent; an antiplatelet agent; an antiobesity agent; an antithrombotic agent; an agent for diabetic vascular complications; and an agent for treatment of heart failure; or a pharmaceutically acceptable salts thereof, optionally in presence of a pharmaceutically acceptable carrier for separate, simultaneous or sequential use. The present invention also relates to a use of such combination for the treatment of mammal including human being. R1, R2, R3, R1, R2, R3, R4, R5, X, Y, A and B and m are as defined in the specification.

Abstract: Methods and systems for reconstructing a full query based on a partial query are disclosed. Existing interfaces for search engines may be rigid and require users to submit full queries to perform searched. The methods and systems described herein may solve these problems by allowing a flexible way for users to submit a partial query and reconstruct a full query based on the partial query. A search may then be performed using the reconstructed query.

Abstract: A search query that includes a first spelling of a term is received. A second spelling of the term is generated. A first set of items that are associated with the first spelling of the term is accessed, and a second set of items that are associated with the second spelling of the term is accessed. A comparison is performed between the first set to the second set. A determination is made as to how to respond to the search query based, at least in part, on the comparison. The response may include a suggested search query that includes the second spelling of the term. The second spelling may be a suggested spelling correction or an alternative spelling. The response may include search results that are relevant to a search query that includes the first spelling of the term, the second spelling, or both the first and second spelling.

Abstract: Methods and systems for reconstructing a full query based on a partial query are disclosed. Existing interfaces for search engines may be rigid and require users to submit full queries to perform searched. The methods and systems described herein may solve these problems by allowing a flexible way for users to submit a partial query and reconstruct a full query based on the partial query. A search may then be performed using the reconstructed query.

Abstract: Multiple concept networks are generated from subsets of received queries. These concept networks can be used in various ways to enhance response to subsequent queries. In one embodiment, concept networks can be merged into a larger concept network that can be used to infer a user's likely intent given a query. In another embodiment, suggestions for related searches obtained using different concept networks can be merged or aggregated. Other users for concept networks in query processing, including assisted search, are also described.

Abstract: Methods and system for generating a topic page for a search query on a search webpage includes receiving a search query at the search engine on a server from a search webpage on a client. The search engine examines the query and categorizes the query along one or more dimensions. A plurality of modules having dynamic content and associated with the one or more categories is identified and a glue page is generated using the identified modules. The glue page is integrated into a topic page. The topic page is returned to the client where it is rendered at the search webpage in response to the search query.

Abstract: Methods for guiding user moderation at a topic page by confidence levels includes presenting a topic page in response to a query. The topic page includes a plurality of modules with content that match the query. The topic page is associated with a confidence level and with one or more page attributes that define the characteristics of the topic page and the modules included therein. One or more modifications to the topic page are received as part of customization of the topic page. The modifications include a plurality of page attributes that define the modification and a plurality of user attributes of a user performing the modification. The modifications are evaluated based on the page attributes and user attributes including confidence levels associated with the topic page and the user. The modifications are implemented based on the evaluation. The implemented modifications enhance the quality and confidence level of the topic page.

Abstract: A system and method for selecting a proxy keyword for an unknown document. An unknown document is received by a receiver. A plurality of candidate documents and corresponding keywords are determined for the unknown document. Using the keywords from the candidate documents, proxy keywords are determined for the unknown document based on a plurality of factors including a length of the keywords, a distance of the candidate documents from the unknown document, a similarity of the text between the unknown document and the respective candidate document, a rank of the keywords within each candidate document, and a frequency of the keyword within its respective candidate document.

Abstract: Search results are processed using search requests, including analyzing received queries in order to provide a more sophisticated understanding of the information being sought. A concept network is generated from a set of queries by parsing the queries into units and defining various relationships between the units. From these concept networks, queries can be automatically categorized into categories, or more generally, can be associated with one or more nodes of a taxonomy. The categorization can be used to alter the search results or the presentation of the results to the user. As an example of alterations of search results or presentation, the presentation might include a list of “suggestions” for related search query terms. As other examples, the corpus searched might vary depending on the category or the ordering or selection of the results to present to the user might vary depending on the category.

Abstract: Methods for optimizing webpage content by micro-bucket testing user customization to the webpage include presenting a plurality of modules at a webpage based on a request from a user. The modules define an intent of the webpage. A change defining customization to one or more modules within the webpage is detected. A test case representing the change is automatically generated. The generated test case is a modified webpage having the customization. The webpage is presented to a first segment of users as a control page and the modified webpage is presented to a second segment of users in response to a request for the webpage. User interaction by the first and segment of users is monitored at the webpage and the modified webpage to determine website metrics of the corresponding webpages. The website metrics is used in defining a new control page of the webpage from the modified webpage or retaining the webpage as the control page.

Abstract: A method and system for generating a topic page for a search query on a search webpage includes receiving a query at the search webpage on a client. The query is transmitted from the search webpage on the client to a search engine on a server. A topic page generator available to the search engine analyzes the query to identify a plurality of dimensions. One or more content modules that match one or more of the dimensions are selected from a plurality of sources based on a weight associated with each of the content modules. The weight defines the ranking of a content module. The content modules for the plurality of dimensions are glued together and presented on the topic page in the order of the corresponding weight of the content modules. The order of presentation identifies the relevancy of the content modules to the query. The presented topic page provides the most relevant content modules for the query, and for a user located in a specific geo location.