Patents by Inventor Deepak Khuntia
Deepak Khuntia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240100361Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.Type: ApplicationFiled: August 24, 2023Publication date: March 28, 2024Applicant: Varian Medical Systems, Inc.Inventors: Renate PARRY, Eric ABEL, Swati GIRDHANI, Stanley MANSFIELD, Patrick KUPELIAN, Deepak KHUNTIA
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Publication number: 20240075314Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.Type: ApplicationFiled: November 1, 2023Publication date: March 7, 2024Applicants: Varian Medical Systems, Inc., Siemens Healthineers International AG, Varian Medical Systems Particle Therapy GmbHInventors: Christel SMITH, Timo KOPONEN, Reynald VANDERSTRAETEN, Anthony MAGLIARI, Eric ABEL, Jessica PEREZ, Michael FOLKERTS, Deepak KHUNTIA
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Patent number: 11865364Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.Type: GrantFiled: December 22, 2022Date of Patent: January 9, 2024Assignees: Varian Medical Systems, Inc., Varian Medical Systems Particle Therapy GmbH, Siemens Healthineers International AGInventors: Christel Smith, Timo Koponen, Reynald Vanderstraeten, Anthony Magliari, Eric Abel, Jessica Perez, Michael Folkerts, Deepak Khuntia
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Patent number: 11771920Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.Type: GrantFiled: September 27, 2021Date of Patent: October 3, 2023Assignee: Varian Medical Systems, Inc.Inventors: Renate Parry, Eric Abel, Swati Girdhani, Stanley Mansfield, Patrick Kupelian, Deepak Khuntia
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Publication number: 20230211178Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.Type: ApplicationFiled: December 22, 2022Publication date: July 6, 2023Inventors: Christel SMITH, Timo KOPONEN, Reynald VANDERSTRAETEN, Anthony MAGLIARI, Eric ABEL, Jessica PEREZ, Michael FOLKERTS, Deepak KHUNTIA
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Publication number: 20230125147Abstract: A dose rate-volume histogram can be generated for a target volume. The dose rate-volume histogram can be stored in computer system memory and used to generate a radiation treatment plan. The radiation treatment plan can be used as the basis for treating a patient using a radiation treatment system.Type: ApplicationFiled: December 23, 2022Publication date: April 27, 2023Inventors: Deepak KHUNTIA, Edward VERTATSCHITSCH, Eric ABEL, Anthony MAGLIARI, Christel SMITH
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Patent number: 11554271Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.Type: GrantFiled: January 12, 2021Date of Patent: January 17, 2023Assignees: Varian Medical Systems, Inc, Varian Medical Systems Particle Therapy GMBH & Co. KG, Varian Medical Systems International AGInventors: Christel Smith, Timo Koponen, Reynald Vanderstraeten, Anthony Magliari, Eric Abel, Jessica Perez, Michael Folkerts, Deepak Khuntia
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Patent number: 11534625Abstract: A dose rate-volume histogram can be generated for a target volume. The dose rate-volume histogram can be stored in computer system memory and used to generate a radiation treatment plan. The radiation treatment plan can be used as the basis for treating a patient using a radiation treatment system.Type: GrantFiled: September 24, 2020Date of Patent: December 27, 2022Assignee: Varian Medical Systems, Inc.Inventors: Deepak Khuntia, Edward Vertatschitsch, Eric Abel, Anthony Magliari, Christel Smith
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Publication number: 20220199221Abstract: These teachings include accessing energy dosing information along with at least one quality-of-care model that correlates at least one categorical energy-based treatment patient quality-of-care outcome with at least one resultant energy-based treatment description. The model can be created via probabilistic mapping that maps patient impact information to dose impartation information to infer non-biological impact to a patient. A patient treatment plan can be optimized for a particular patient as a function of the foregoing information to provide corresponding resultant benefit trade-of evaluation information. This benefit trade-off evaluation information can be displayed to a user to permit the user to explore the benefit trade-off evaluation information to thereby identify a resultant energy-based treatment plan having a selected balance between dosing a treatment target with energy and a quality-of-care impact on the particular patient.Type: ApplicationFiled: December 21, 2020Publication date: June 23, 2022Inventors: Deepak Khuntia, Corey E. Zankowski, Paritosh Ambekar, Alexander E. Maslowski
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Publication number: 20220008750Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.Type: ApplicationFiled: September 27, 2021Publication date: January 13, 2022Applicant: VARIAN MEDICAL SYSTEMS, INC.Inventors: Renate PARRY, Eric ABEL, Swati GIRDHANI, Stanley MANSFIELD, Patrick KUPELIAN, Deepak KHUNTIA
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Patent number: 11173325Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.Type: GrantFiled: July 20, 2018Date of Patent: November 16, 2021Assignee: Varian Medical Systems, Inc.Inventors: Renate Parry, Eric Abel, Swati Girdhani, Stanley Mansfield, Patrick Kupelian, Deepak Khuntia
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Patent number: 11116995Abstract: A dose rate-volume histogram is generated for a target volume. The dose rate-volume histogram can be stored in computer system memory and used to generate a radiation treatment plan. An irradiation time-volume histogram can also be generated for the target volume. The irradiation time-volume histogram can be stored in computer system memory and used to generate the radiation treatment plan.Type: GrantFiled: March 6, 2019Date of Patent: September 14, 2021Assignee: Varian Medical Systems, Inc.Inventors: Deepak Khuntia, Edward Vertatschitsch, Eric Abel, Anthony Magliari, Christel Smith
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Publication number: 20210128946Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.Type: ApplicationFiled: January 12, 2021Publication date: May 6, 2021Inventors: Christel SMITH, Timo KOPONEN, Reynald VANDERSTRAETEN, Anthony MAGLIARI, Eric ABEL, Jessica PEREZ, Michael FOLKERTS, Deepak KHUNTIA
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Publication number: 20210113856Abstract: In various embodiments, a radiation therapy method can include loading a planning image of a target in a human. In addition, the position of the target can be monitored. A computation can be made of an occurrence of substantial alignment between the position of the target and the target of the planning image. Furthermore, after the computing, a beam of radiation is triggered to deliver a dosage to the target in a short period of time (e.g., less than a second).Type: ApplicationFiled: December 23, 2020Publication date: April 22, 2021Inventors: Christel SMITH, Corey ZANKOWSKI, Jan Hein TIMMER, Wolfgang KAISSL, Deepak KHUNTIA, Eric ABEL, Josh STAR-LACK, Camille NOEL
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Patent number: 10918886Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.Type: GrantFiled: June 10, 2019Date of Patent: February 16, 2021Assignees: Varian Medical Systems, Inc., Varian Medical Systems International AG, Varian Medical Systems Particle Therapy GMBHInventors: Christel Smith, Timo Koponen, Reynald Vanderstraeten, Anthony Magliari, Eric Abel, Jessica Perez, Michael Folkerts, Deepak Khuntia
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Patent number: 10898730Abstract: In various embodiments, a radiation therapy method can include loading a planning image of a target in a human. In addition, the position of the target can be monitored. A computation can be made of an occurrence of substantial alignment between the position of the target and the target of the planning image. Furthermore, after the computing, a beam of radiation is triggered to deliver a dosage to the target in a short period of time (e.g., less than a second).Type: GrantFiled: December 31, 2018Date of Patent: January 26, 2021Assignees: Varian Medical Systems International AG, Varian Medical Systems, IncInventors: Christel Smith, Corey Zankowski, Jan Timmer, Wolfgang Kaissl, Deepak Khuntia, Eric Abel, Josh Star-Lack, Camille Noel
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Publication number: 20210016108Abstract: A dose rate-volume histogram can be generated for a target volume. The dose rate-volume histogram can be stored in computer system memory and used to generate a radiation treatment plan. The radiation treatment plan can be used as the basis for treating a patient using a radiation treatment system.Type: ApplicationFiled: September 24, 2020Publication date: January 21, 2021Inventors: Deepak KHUNTIA, Edward VERTATSCHITSCH, Eric ABEL, Anthony MAGLIARI, Christel SMITH
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Publication number: 20200384289Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.Type: ApplicationFiled: June 10, 2019Publication date: December 10, 2020Inventors: Christel SMITH, Timo KOPONEN, Reynald VANDERSTRAETEN, Anthony MAGLIARI, Eric ABEL, Jessica PEREZ, Michael FOLKERTS, Deepak KHUNTIA
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Patent number: 10814144Abstract: A dose rate-volume histogram can be generated for a target volume. The dose rate-volume histogram can be stored in computer system memory and used to generate a radiation treatment plan. The radiation treatment plan can be used as the basis for treating a patient using a radiation treatment system.Type: GrantFiled: March 6, 2019Date of Patent: October 27, 2020Assignee: Varian Medical Systems, Inc.Inventors: Deepak Khuntia, Edward Vertatschitsch, Eric Abel, Anthony Magliari, Christel Smith
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Publication number: 20200282231Abstract: A dose rate-volume histogram is generated for a target volume. The dose rate-volume histogram can be stored in computer system memory and used to generate a radiation treatment plan. An irradiation time-volume histogram can also be generated for the target volume. The irradiation time-volume histogram can be stored in computer system memory and used to generate the radiation treatment plan.Type: ApplicationFiled: March 6, 2019Publication date: September 10, 2020Inventors: Deepak KHUNTIA, Edward VERTATSCHITSCH, Eric ABEL, Anthony MAGLIARI, Christel SMITH