Patents by Inventor Deepak Nagrath

Deepak Nagrath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERAPY FOR PROGRAMMED CELL DEATH IN A SUBJECT TRANSPLANTED WITH A DONOR LIVER CARRYING THE PNPLA3 RS738409:G VARIANT
    Publication number: 20250001009
    Abstract: Methods are disclosed herein for promoting survival of a donor liver in a recipient subject, wherein the donor liver is homozygous for rs738409:G mutation in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene. The method can include administering to the subject glutathione (GSH) and/or a nucleic acid molecule encoding a component of the ferroptosis pathway (such as GPX4).
    Type: Application
    Filed: November 21, 2022
    Publication date: January 2, 2025
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Regents of the University of Michigan, Kyushu University, National University Corporation
    Inventors: Alejandro Soto-Gutierrez, Kazuki Takeishi, Kazutoyo Morita, Nils Haep, Rodrigo Machado Florentino, Abhinav Achreja, Deepak Nagrath, Olamide Animasahun, Tomoharu Yoshizumi
  • COMPOSITIONS AND METHODS FOR INCREASING THE EFFICACY OF IMMUNOTHERAPIES AND VACCINES
    Publication number: 20240299299
    Abstract: This invention relates generally to compositions and methods for increasing the efficacy of immunotherapies and vaccines. In particular, the present invention relates to compositions comprising one or more metabolites (derivatives, prodrugs, or pharmaceutical salts thereof), and related methods of increasing the efficacy of immunotherapies and vaccines through administration of such compositions.
    Type: Application
    Filed: June 22, 2022
    Publication date: September 12, 2024
    Inventors: James J. MOON, Kai HAN, Deepak NAGRATH, Kim HUTCHINGS, Martin CLASBY
  • HUMAN ADIPOCYTE-DERIVED BASEMENT MEMBRANE FOR TISSUE ENGINEERING APPLICATIONS
    Publication number: 20130273658
    Abstract: The present disclosure generally relates to tissue engineering. More particularly, the present disclosure relates to the generation of a new biologically active and biocompatible human derived materials useful in tissue engineering applications.
    Type: Application
    Filed: April 11, 2013
    Publication date: October 17, 2013
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Aaron Damm, Deepak Nagrath
  • Designing synthetic biological circuits using optimality and nonequilibrium thermodynamics
    Patent number: 8504948
    Abstract: In general, the invention relates to a method for designing a biological circuit. The method includes obtaining a target circuit objective for the biological circuit, determining an objective function corresponding to the target circuit objective, obtaining a number of nodes for the biological circuit, obtaining a set of possible circuit subgraphs using the number of nodes, obtaining a specific dissipation energy (SDE) for each one of the set of possible circuit subgraphs by optimizing the objective function, selecting at least one circuit subgraph from the set of possible circuit subgraphs with the lowest SDE, and designing the biological circuit using the at least one selected one circuit subgraph.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: August 6, 2013
    Assignees: William Marsh Rice University, The General Hospital Corporation
    Inventors: Deepak Nagrath, Marco Avila-Elchiver, Martin Yarmush
  • DESIGNING SYNTHETIC BIOLOGICAL CIRCUITS USING OPTIMALITY AND NONEQUILIBRIUM THERMODYNAMICS
    Publication number: 20120117518
    Abstract: In general, the invention relates to a method for designing a biological circuit. The method includes obtaining a target circuit objective for the biological circuit, determining an objective function corresponding to the target circuit objective, obtaining a number of nodes for the biological circuit, obtaining a set of possible circuit subgraphs using the number of nodes, obtaining a specific dissipation energy (SDE) for each one of the set of possible circuit subgraphs by optimizing the objective function, selecting at least one circuit subgraph from the set of possible circuit subgraphs with the lowest SDE, and designing the biological circuit using the at least one selected one circuit subgraph.
    Type: Application
    Filed: September 30, 2011
    Publication date: May 10, 2012
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Deepak Nagrath, Marco Avila-Elchiver, Martin Yarmush