Abstract: A hybrid power plant including a plurality of power sources and controllers, a hybrid plant controller, and a computing system. The controllers operate the power sources according to operating set points. The hybrid plant controller transmits the operating set points to the controllers. The computing system is coupled to the hybrid plant controller and receives a first set of input parameters from a first subscriber, and carries out a first level of services to which the first subscriber subscribes to determine operating parameters for the first subscriber. The computing system receives a second set of input parameters from a second subscriber and carries out a second level of services to which the second subscriber subscribes to determine operating parameters for the second subscriber. The computing system then computes the operating set points based on aggregate operating parameters for the first and second subscribers.

Abstract: The present invention relates to a system and method for optimizing performance of a process by constructing a KPI tree structure modelling workflow of the process using data received from a client device; autonomously monitoring a plurality of interconnected metrics by analysing data from the KPI tree structure; determining one or more root causes for an issue affecting the performance based on the autonomous monitoring of the plurality of interconnected metrics; recommending one or more actions correlating with one or more levels in the workflow to remediate the one or more root causes, supported by controlled experimentation as a sub-step; enabling performance of the one or more actions in the process workflow by integrating the one or more actions with execution of process workflow; and tracking impact of the one or more actions using continually received feedback on implemented actions and analysis of data from the KPI tree structure.

Abstract: A method for controlling a power output of a power generating unit includes receiving at least two measurement data sets from a location of integration of a power generating unit to an electrical grid. Each measurement data set includes a plurality of electrical parameters. The method further includes generating a grid model of the electrical grid based on the at least two measurement data sets. The grid model is characterized by an equivalent grid voltage and an equivalent grid impedance. The method further includes computing a strength value of the electrical grid based on the grid model, using the at least two measurement data sets. The method also includes controlling the power output of a power generating unit based on the strength value of the electrical grid.

Abstract: A system collects ongoing user activity information relating to a predefined activity, using one or more devices having a predefined relationship to a user and determines an environmental impact value of the predefined activity based on environmental impact caused by one or more aspects of the predefined activity. The system determines at least one change to the predefined activity that would achieve a diminished environmental impact, suggests the change to the user via a device interface and, responsive to acceptance of the change, implements a control strategy to assist the user in achieving the change.

Abstract: A method for seismic loss assessment including receiving by a computer system computer-readable input data regarding a seismic hazard and building conditions, generating by the computer system one or more mitigation options and for each of the mitigation options, configuring the computer system to: determine a structural response, determine damage states from the structural response, determine an outcome of each of the damage states; and, output a representation of each of the outcomes for each of the damage states. The output is used in a seismic risk mitigation plan and/or design for one or more building structures.

Abstract: A method for controlling an energy generation and storage system using a multi-layer architecture is provided. The method includes determining, by one or more control devices, a power or energy generation for the energy generation and storage system at a first layer of the multi-layer architecture. The method includes determining, by the one or more control devices, a power or energy set point for the system at a second layer of the multi-layer architecture. The method includes controlling, by the one or more control devices, the energy generation and storage system based, at least in part, on the power or energy setpoint.

Abstract: A hybrid power plant including a plurality of power sources and controllers, a hybrid plant controller, and a computing system. The controllers operate the power sources according to operating set points. The hybrid plant controller transmits the operating set points to the controllers. The computing system is coupled to the hybrid plant controller and receives a first set of input parameters from a first subscriber, and carries out a first level of services to which the first subscriber subscribes to determine operating parameters for the first subscriber. The computing system receives a second set of input parameters from a second subscriber and carries out a second level of services to which the second subscriber subscribes to determine operating parameters for the second subscriber. The computing system then computes the operating set points based on aggregate operating parameters for the first and second subscribers.

Abstract: A method for controlling a wind farm electrical power system is presented. The wind farm electrical power system includes a controller and a plurality of wind turbines electrically connected to an electrical grid through a point of interconnection. Each wind turbine includes a voltage regulator. The method includes receiving, via the controller, one or more electrical signals associated with the point of interconnection for a frequency domain. Further, the method includes estimating, via an estimator of the controller, a voltage sensitivity of the electrical grid using the one or more electrical signals. Moreover, the method includes dynamically controlling a voltage of the wind farm electrical power system at the point of interconnection based on the voltage sensitivity.

Abstract: There is described a nucleic acid molecule comprising a nucleotide sequence encoding for a functional ?-galactosidase A protein wherein the nucleotide sequence has at least 85% identity to the sequence of SEQ ID NO. 1. Also described is a vector, host cell or transgenic animal comprising the nucleic acid molecule; and a pharmaceutical composition comprising the nucleic acid molecule or the vector. Further, the use of the nucleic acid molecule in a method of treating Fabry disease is described.

Abstract: There is described a nucleic acid molecule comprising a nucleotide sequence encoding for a functional ?-galactosidase A protein wherein the nucleotide sequence has at least 85% identity to the sequence of SEQ ID NO. 1. Also described is a vector, host cell or transgenic animal comprising the nucleic acid molecule; and a pharmaceutical composition comprising the nucleic acid molecule or the vector. Further, the use of the nucleic acid molecule in a method of treating Fabry disease is described.

Abstract: There is described a new gene therapy approach for treating Wilson's disease in which a nucleic acid molecule is used which comprises a nucleotide sequence encoding for a functional ATP7B protein wherein the nucleotide sequence has at least 85% identity to the sequence of SEQ ID NO: 1. Also described are vectors comprising the nucleotide sequence and methods and uses thereof.

Abstract: A method for controlling a wind farm electrical power system is presented. The wind farm electrical power system includes a controller and a plurality of wind turbines electrically connected to an electrical grid through a point of interconnection. Each wind turbine includes a voltage regulator. The method includes receiving, via the controller, one or more electrical signals associated with the point of interconnection for a frequency domain. Further, the method includes estimating, via an estimator of the controller, a voltage sensitivity of the electrical grid using the one or more electrical signals. Moreover, the method includes dynamically controlling a voltage of the wind farm electrical power system at the point of interconnection based on the voltage sensitivity.

Abstract: A method for estimating grid strength of a power grid connected to a renewable energy farm having a plurality of renewable energy power systems includes measuring, at least, a voltage, an active power, and a reactive power at a point of interconnection of the renewable energy farm to the power grid. The method also includes determining a sensitivity of the voltage to at least one of the active power or the reactive power at the point of interconnection. Further, the method includes determining the grid strength of the power grid as a function of the sensitivity of the voltage to at least one of the active power or the reactive power at the point of interconnection. In addition, the method includes dynamically determining at least one of an active power command or a reactive power command for the renewable energy farm at the point of interconnection based on the grid strength.

Abstract: A method for operating a wind turbine power system that supplies real and reactive power to a grid includes operating a generator of the wind turbine power system up to a first speed limit. The method also includes monitoring a wind speed at the wind turbine power system. When the wind speed drops below a predetermined threshold, the method includes reducing the first speed limit of the generator to a reduced speed limit of the generator. Further, the method includes operating the generator at the reduced speed limit for as long as the wind speed remains below the predetermined threshold so as to optimize a tip-speed-ratio of the wind turbine power system during low wind speeds, thereby increasing power production of the wind turbine power system at low wind speeds.

Abstract: A method for operating a wind turbine power system that supplies real and reactive power to a grid includes operating a generator of the wind turbine power system up to a first speed limit. The method also includes monitoring a wind speed at the wind turbine power system. When the wind speed drops below a predetermined threshold, the method includes reducing the first speed limit of the generator to a reduced speed limit of the generator. Further, the method includes operating the generator at the reduced speed limit for as long as the wind speed remains below the predetermined threshold so as to optimize a tip-speed-ratio of the wind turbine power system during low wind speeds, thereby increasing power production of the wind turbine power system at low wind speeds.

Abstract: A method for estimating grid strength of a power grid connected to a renewable energy farm having a plurality of renewable energy power systems includes measuring, at least, a voltage, an active power, and a reactive power at a point of interconnection of the renewable energy farm to the power grid. The method also includes determining a sensitivity of the voltage to at least one of the active power or the reactive power at the point of interconnection. Further, the method includes determining the grid strength of the power grid as a function of the sensitivity of the voltage to at least one of the active power or the reactive power at the point of interconnection. In addition, the method includes dynamically determining at least one of an active power command or a reactive power command for the renewable energy farm at the point of interconnection based on the grid strength.

Abstract: An electrical power system includes a system-level controller and a plurality of clusters of subsystems defining a stator power path and a converter power path for providing power to the power grid. The converter power path includes a partial power transformer. The system further includes a cluster transformer connecting each cluster to the power grid and a plurality of cluster-level controllers communicatively coupled with the system-level controller. Each of the clusters is communicatively coupled with one of the cluster-level controllers. Thus, the system-level controller regulates system-level active and/or reactive power based on required active or reactive power for the system, respectively, and compares the system-level active or reactive power with preferred values thereof.

Abstract: There is described a gene therapy approach for treating Wilson's disease in which a nucleic acid molecule is used which comprises a nucleotide sequence encoding for a functional ATP7B protein wherein the nucleotide sequence has at least 85% identity to the sequence of SEQ ID NO. 1. Also described are vectors comprising the nucleotide sequence and methods and uses thereof.

Abstract: A method for controlling an energy generation and storage system using a multi-layer architecture is provided. The method includes determining, by one or more control devices, a power or energy generation for the energy generation and storage system at a first layer of the multi-layer architecture. The method includes determining, by the one or more control devices, a power or energy set point for the system at a second layer of the multi-layer architecture. The method includes controlling, by the one or more control devices, the energy generation and storage system based, at least in part, on the power or energy setpoint.

Abstract: A method for seismic loss assessment including receiving by a computer system computer-readable input data regarding a seismic hazard and building conditions, generating by the computer system one or more mitigation options and for each of the mitigation options, configuring the computer system to: determine a structural response, determine damage states from the structural response, determine an outcome of each of the damage states; and, output a representation of each of the outcomes for each of the damage states. The output is used in a seismic risk mitigation plan and/or design for one or more building structures.