Abstract: A method, system and computer readable medium for remote mirroring are described. The method can include receiving a customer data frame and making two copies of the customer data frame. An outer header, such as a mac-in-mac header, can be added to each copy. The outer header of the first copy can be configured for normal processing, while the outer header of the second copy can be configured for remote mirroring. A switch can recognize the header configured for mirroring in the second copy based on a service identifier in the header and process the second copy for mirroring on one or more ports on one or more bridges.

Abstract: A coverage robot includes a chassis, a drive system, and a cleaning assembly. The cleaning assembly includes a housing and at least one driven cleaning roller including an elongated core with end mounting features defining a central longitudinal axis of rotation, multiple floor cleaning bristles extending radially outward from the core, and at least one compliant flap extending radially outward from the core to sweep a floor surface. The flap is configured to prevent errant filaments from spooling tightly about the core to aid subsequent removal of the filaments. In another aspect, a coverage robot includes a chassis, a drive system, a controller, and a cleaning assembly. The cleaning assembly includes a housing and at least one driven cleaning roller. The coverage robot includes a roller cleaning tool carried by the chassis and configured to longitudinally traverse the roller to remove accumulated debris from the cleaning roller.

Abstract: An autonomous coverage robot includes a body having at least one outer wall, a drive system disposed on the body and configured to maneuver the robot over a work surface, and a cleaning assembly carried by the body. The cleaning assembly includes first and second cleaning rollers rotatably coupled to the body, a suction assembly having a channel disposed adjacent at least one of the cleaning rollers, and a container in fluid communication with the channel. The container is configured to collect debris drawn into the channel. The suction assembly is configured to draw debris removed from the work surface by at least one of the cleaning rollers into the channel, and the container has a wall common with the at least one outer wall of the body.

Abstract: The present invention is directed to compositions, methods and kits for regulation of gene therapies for Huntington's Disease, including, without limitation, reversible gene therapies and allele-specific therapies.

Abstract: A coverage robot including a chassis, multiple drive wheel assemblies disposed on the chassis, and a cleaning assembly carried by the chassis. Each drive wheel assembly including a drive wheel assembly housing, a wheel rotatably coupled to the housing, and a wheel drive motor carried by the drive wheel assembly housing and operable to drive the wheel. The cleaning assembly including a cleaning assembly housing, a cleaning head rotatably coupled to the cleaning assembly housing, and a cleaning drive motor carried by cleaning assembly housing and operable to drive the cleaning head. The wheel assemblies and the cleaning assembly are each separately and independently removable from respective receptacles of the chassis as complete units.

Abstract: A coverage robot includes a chassis, a drive system, and a cleaning assembly. The cleaning assembly includes a housing and at least one driven cleaning roller including an elongated core with end mounting features defining a central longitudinal axis of rotation, multiple floor cleaning bristles extending radially outward from the core, and at least one compliant flap extending radially outward from the core to sweep a floor surface. The flap is configured to prevent errant filaments from spooling tightly about the core to aid subsequent removal of the filaments. In another aspect, a coverage robot includes a chassis, a drive system, a controller, and a cleaning assembly. The cleaning assembly includes a housing and at least one driven cleaning roller. The coverage robot includes a roller cleaning tool carried by the chassis and configured to longitudinally traverse the roller to remove accumulated debris from the cleaning roller.

Abstract: The instant invention provides a method for improving efficiency of RNA delivery to cells. The method comprises applying a low strength electric field to the cells and then after a certain time period, administering the ribonucleic acid sequence to the cells. Devices, kits, and RNA molecules suitable for delivery and devices suitable for practicing the disclosed methods are also provided.

Abstract: The invention provides novel combination therapies for treating Huntington's disease which comprise a) BDNF or suitable fragments thereof and b) agents capable of causing inhibition of a gene responsible for the neurodegenerative disease. The invention provides nucleic acid sequences, methods, and systems suitable for applications of these combination therapies.

Abstract: Broad cerebrospinal fluid (CSF) distribution of an agent is achievable by delivering the agent in a liquid formulation to the CSF at flow rates less than 500 microliters per hour, such as between about 2 microliters per hour and about 100 microliters per hour.

Abstract: A coverage robot includes a chassis, a drive system, and a cleaning assembly. The cleaning assembly includes a housing and at least one driven cleaning roller including an elongated core with end mounting features defining a central longitudinal axis of rotation, multiple floor cleaning bristles extending radially outward from the core, and at least one compliant flap extending radially outward from the core to sweep a floor surface. The flap is configured to prevent errant filaments from spooling tightly about the core to aid subsequent removal of the filaments. In another aspect, a coverage robot includes a chassis, a drive system, a controller, and a cleaning assembly. The cleaning assembly includes a housing and at least one driven cleaning roller. The coverage robot includes a roller cleaning tool carried by the chassis and configured to longitudinally traverse the roller to remove accumulated debris from the cleaning roller.

Abstract: The instant invention provides a method for improving efficiency of RNA delivery to cells. The method comprises applying a low strength electric field to the cells and then after a certain time period, administering the ribonucleic acid sequence to the cells. Devices, kits, and RNA molecules suitable for delivery and devices suitable for practicing the disclosed methods are also provided.

Abstract: The instant invention provides a method for improving efficiency of RNA delivery to cells. The method comprises applying a low strength electric field to the cells and then after a certain time period, administering the ribonucleic acid sequence to the cells. Devices, kits, and RNA molecules suitable for delivery and devices suitable for practicing the disclosed methods are also provided.

Abstract: The present invention is directed to compositions, methods and kits for regulation of gene therapies for Huntington's Disease, including, without limitation, reversible gene therapies and allele-specific therapies.

Abstract: The invention provides novel combination therapies for treating Huntington's disease which comprise a) BDNF or suitable fragments thereof and b) agents capable of causing inhibition of a gene responsible for the neurodegenerative disease. The invention provides nucleic acid sequences, methods, and systems suitable for applications of these combination therapies.

Abstract: An autonomous coverage robot includes a body, a drive system disposed on the body, and a cleaning assembly disposed on the body and configured to engage a floor surface while the robot is maneuvered across the floor surface. The cleaning assembly includes a driven cleaning roller, a cleaning bin disposed on the body for receiving debris agitated by the cleaning roller, and an air mover. The cleaning bin includes a cleaning bin body having a cleaning bin entrance disposed adjacent to the cleaning roller and a roller scraper disposed on the cleaning bin body for engaging the cleaning roller. The cleaning bin body has a holding portion in pneumatic communication with the cleaning bin entrance, and the air mover is operable to move air into the cleaning bin entrance.

Abstract: A system includes (i) a medium having a solid support to which an antibody directed to target molecule is bound, (ii) a reservoir for containing the medium, (iii) a first catheter, and (iv) a second catheter. The first catheter has a proximal end portion, an opening for removal of cerebrospinal fluid from a subject, and a lumen extending from the proximal end portion to the opening. The first catheter is operably couplable to the reservoir such that fluid is capable of flowing from the lumen to the reservoir. The second catheter has a proximal end portion, a delivery region for returning cerebrospinal fluid to the subject, and a lumen extending from the proximal end portion to the delivery region. The second catheter is operably couplable to the reservoir such that fluid is capable of flowing from the reservoir to the lumen.

Abstract: An autonomous coverage robot includes a body having at least one outer wall, a drive system disposed on the body and configured to maneuver the robot over a work surface, and a cleaning assembly carried by the body. The cleaning assembly includes first and second cleaning rollers rotatably coupled to the body, a suction assembly having a channel disposed adjacent at least one of the cleaning rollers, and a container in fluid communication with the channel. The container is configured to collect debris drawn into the channel. The suction assembly is configured to draw debris removed from the work surface by at least one of the cleaning rollers into the channel, and the container has a wall common with the at least one outer wall of the body.

Abstract: Methods, agents and devices for treating a patient to reduce accumulation of certain proteins in the brain are described. Such proteins include A?, and the methods, agents and devices are useful for reducing the accumulation of A?, which is a principal constituent of the plaques associated with such diseases as Alzheimer's disease (AD). Antibodies to A?, when delivered systemically or directly into the central nervous system, improve cognitive deficits in a transgenic mouse model of AD. However, unlike peripheral of antibodies to A?, which increased cerebral vascular plaques and hemorrhages, direct central administration did not result in such an increase cerebral vascular plaques and hemorrhages.

Abstract: A coverage robot including a chassis, multiple drive wheel assemblies disposed on the chassis, and a cleaning assembly carried by the chassis. Each drive wheel assembly including a drive wheel assembly housing, a wheel rotatably coupled to the housing, and a wheel drive motor carried by the drive wheel assembly housing and operable to drive the wheel. The cleaning assembly including a cleaning assembly housing, a cleaning head rotatably coupled to the cleaning assembly housing, and a cleaning drive motor carried by cleaning assembly housing and operable to drive the cleaning head. The wheel assemblies and the cleaning assembly are each separately and independently removable from respective receptacles of the chassis as complete units.

Abstract: An autonomous coverage robot includes a chassis, a drive system to maneuver the robot, an edge cleaning head carried, and a controller. The controller is configured to monitor motor current associated with the edge cleaning head and to reverse bias the edge cleaning head motor in response to an elevated motor current, while continuing to maneuver the robot across the floor. In another aspect, an autonomous coverage robot includes a drive system, a bump sensor, and a proximity sensor. The drive system is configured to reduce a speed setting in response to a signal from the proximity sensor indicating detection of a potential obstacle in a forward direction, while continuing to advance the robot according to a heading setting. Furthermore, the drive system is configured to alter the heading setting in response to a signal received from the bump sensor indicating contact with an obstacle.